Microcystin-producing blooms—a serious global public health issue

Figueiredo, Daniela; Azeiteiro, Ulisses Miranda; Esteves, Sónia M.; Gonçalves, Fernando; Pereira, Mário Jorge

doi:10.1016/j.ecoenv.2004.04.006

Cited by 496 publications

(317 citation statements)

References 109 publications

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“…Microcystis, the most frequently reported cyanobacterial genus responsible for freshwater cyanobacterial blooms worldwide , has long been a primary focus of attention because of its potential to produce a potent cyanotoxin called microcystins (MCs) (Haider et al, 2003). Special attention has been given to hepatotoxic MCs due to their ability to lead to serious poisoning but also due to their cancer promotion potential to humans which is caused by chronic exposure to low MC concentrations in drinking water (de Figueiredo et al, 2004). Research interest in this genus has increased steadily for the problems associated with Microcystis blooms and MCs.…”

Section: Introductionmentioning

confidence: 99%

Seasonal dynamics of water bloom-forming Microcystis morphospecies and the associated extracellular microcystin concentrations in large, shallow, eutrophic Dianchi Lake

Лин

Gan

et al. 2014

Journal of Environmental Sciences

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Section: Introductionmentioning

confidence: 99%

Seasonal dynamics of water bloom-forming Microcystis morphospecies and the associated extracellular microcystin concentrations in large, shallow, eutrophic Dianchi Lake

Лин

Gan

et al. 2014

Journal of Environmental Sciences

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“…Among cyanotoxins, hepatotoxic microcystins (MCs) are the most common and produced by numerous genera, including Microcystis, Planktothrix, Aphanizomenon, Anabaena (Chorus and Bartram, 1999;Figueiredo et al, 2004). These cyanotoxins can pose serious threats to human and environmental health via contamination of drinking water, recreational exposure to waterborne toxins, and possible accumulation of toxins in the food-web (Chorus et al, 2000;Paerl et al, 2001;Codd et al, 2005;Falconer and Humpage, 2006).…”

Section: Introductionmentioning

confidence: 99%

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Dong

Zhu

Han

et al. 2011

Environmental Toxicology

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A 90-day growth trial was conducted on hybrid sturgeon (Acipenser baeri $ 3 A. gueldenstaedtii #) to investigate the effect of dietary inclusion of cyanobacteria on growth, feed utilization, and fish tissue microcystins (MCs) accumulation and the recovery of fish when they were free of cyanobacteria. Four diets were formualted isonitrogenous and isocaloric to contain different MCs concentrations: the control diet (free of cyanobacteria), low cyanobacteria diet (LCD, 26.60 lg MCs/g diet), medium cyanobacteria diet (MCD, 78.82 lg MCs/g diet), and high cyanobacteria diet (HCD, 201.03 lg MCs/g diet). During the first 47 days, each diet was fed to fish in five replicates and then all fish were fed the control diet during the next 43 days. The results showed that a dose-dependent decrease in feeding rate (FR) and specific growth rate (SGR) were observed in the fish fed with MCD and HCD. MCs contents in fish liver, intestine, and dorsal white muscle increased with dietary MCs and were time dependent (P \ 0.05). After the 43-day recovery, there were no significant differences in FR or SGR between the fish previously fed LCD or MCD and the fish fed with the control diet (P [ 0.05), while the fish previously fed HCD showed higher FR and SGR than those fed the control diet (P \ 0.05). MCs clearance in fish liver and intestine showed time-dependence during the 43-day recovery. # 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 161-170, 2011.

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“…Microcystins are the most widespread type of cyanobacteria toxins found in freshwater systems and drinking waters (Falconer, 1999;de Figueiredo et al, 2004), which represent potential stress and hazard risk to human health (Dawson, 1998). Microcystins are potent tumor promoters and they can inhibit protein phosphatases 1 and 2A (Runnegar et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Identification of microcystins in waters used for daily life by people who live on Tai Lake during a serious cyanobacteria dominated bloom with risk analysis to human health

Zhang

Zhu

2008

Environmental Toxicology

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Tai Lake is the third largest freshwater lake in China with annual cyanobacteria blooms. Microcystins produced by these blooms have serious health risks for populations surrounding the lake, especially for people living on Tai Lake, because they usually drink raw lake water after a simple alum treatment. This study presents data on the detection and identification of microcystins in waters used for daily life by people living on Tai Lake, during the cyanobacterial blooming in July 2007. The health risks from drinking these microcystin-polluted waters were also calculated. The main microcystins detected by high-performance liquid chromatography-electrospray ionization mass spectrometry in the water samples collected from two parts of Tai Lake (Wuli Lake and Meiliang Bay) were MC-LR (4.33-12.27 lg/L), MC-RR (8.36-16.91 lg/L) and MC-YR (1.41-5.57 lg/L). Risk assessment showed that the drinking water simply treated by alum was not safe. The lowest calculated hazards ratios in all water samples was 6.4, which indicated that the risk of microcystins exposure from drinking water was over six times higher than the tolerable daily intake (TDI) recommended by The World Health Organization (WHO). Further studies should be conducted to elucidate the relationships between the epidemiology of people living on Tai Lake and microcystins exposure from drinking water. # 2008 Wiley Periodicals, Inc. Environ Toxicol 24: 82-86, 2009

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Microcystin-producing blooms—a serious global public health issue

Cited by 496 publications

References 109 publications

Seasonal dynamics of water bloom-forming Microcystis morphospecies and the associated extracellular microcystin concentrations in large, shallow, eutrophic Dianchi Lake

Seasonal dynamics of water bloom-forming Microcystis morphospecies and the associated extracellular microcystin concentrations in large, shallow, eutrophic Dianchi Lake

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Identification of microcystins in waters used for daily life by people who live on Tai Lake during a serious cyanobacteria dominated bloom with risk analysis to human health

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