Microdialysis Sampling as a Sample Preparation Method

Nandi, Pradyot; Lunte, Susan M.

doi:10.1002/9780813823621.ch6

Cited by 5 publications

(4 citation statements)

References 178 publications

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“…To maintain good temporal resolution and high sensitivity, microbore and capillary columns are commonly employed. Detection methods include ultraviolet (UV), laser-induced fluorescence (LIF), and electrochemical (EC) detection, as well as MS (59). In an early BBB study, microbore LC-UV was used in conjunction with microdialysis sampling to determine the effects of anesthesia on the transport of tacrine across the BBB (60).…”

Section: In Vivo Methods For Studying Transport Of Substances Acromentioning

confidence: 99%

Analytical and Biological Methods for Probing the Blood-Brain Barrier

Sloan

Nandi

Linz³

et al. 2012

Annual Rev. Anal. Chem.

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The blood-brain barrier (BBB) is an important interface between the peripheral and central nervous systems. It protects the brain against the infiltration of harmful substances and regulates the permeation of beneficial endogenous substances from the blood into the extracellular fluid of the brain. It can also present a major obstacle in the development of drugs that are targeted for the central nervous system. Several methods have been developed to investigate the transport and metabolism of drugs, peptides, and endogenous compounds at the BBB. In vivo methods include intravenous injection, brain perfusion, positron emission tomography, and microdialysis sampling. Researchers have also developed in vitro cell-culture models that can be employed to investigate transport and metabolism at the BBB without the complication of systemic involvement. All these methods require sensitive and selective analytical methods to monitor the transport and metabolism of the compounds of interest at the BBB.

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Section: In Vivo Methods For Studying Transport Of Substances Acromentioning

confidence: 99%

Analytical and Biological Methods for Probing the Blood-Brain Barrier

Sloan

Nandi

Linz³

et al. 2012

Annual Rev. Anal. Chem.

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“…Affi nity dialysis in a microfl uidic format has been used as a sample preparation method prior to ESI -MS for the trace analysis of food residues as well as for high -throughput drug assays [227] . A recent review from our group outlines various applications of microdialysis as a sample preparation method [20] . Since microdialysis measures only the non -protein -bound fraction, it has also been used to determine the degree of protein binding of drugs [228,229] .…”

Section: Representative Applications Of MD To Pharmaceutical Analysismentioning

confidence: 99%

“…A variety of detection methods have also been used, including ultraviolet, fl uorescence, electrochemical, and mass spectrometric detection. This chapter, which is focused on analytical aspects of microdialysis sampling, includes information on both sampling and analysis that has recently been reviewed by our group in two other publications [19,20] . …”

Section: Introductionmentioning

confidence: 99%

Analytical Considerations for Microdialysis Sampling

Nandi

Kuhnline

Lunte

2011

Applications of Microdialysis in Pharmaceutical Science

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“…The online coupling of sample preparation techniques with LC began from the connection of solid phase extraction (SPE) to liquid chromatography (LC) [7]. Recently, a variety of online sample preparation techniques have been emerging, such as solid phase microextraction (SPME) [8,9,10], microextraction in packed syringe (MEPS) [11,12], stir bar sorptive extraction (SBSE) [13], liquid phase microextraction (LPME) [14], accelerated solvent extraction, (ASE) [15], microdialysis (MD) [16], microwave assisted extraction (MAE) [17], supercritical fluids extraction (SFE) [18], and other modern technologies which can overcome weaknesess and shortcomings of the traditional techniques of sample preparation.…”

Section: Introductionmentioning

confidence: 99%

Solvent Front Position Extraction with Semi-Automatic Device as a Powerful Sample Preparation Procedure Prior to Quantitative Instrumental Analysis

et al. 2019

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The new prototype device is applied to the Solvent Front Position Extraction (SFPE) sample preparation procedure. The mobile phase is deposited onto the chromatographic plate adsorbent layer by the pipette, which is moved, according to programmed movement path, by a 3D printer mechanism. The application of the prototype device to SFPE procedure leads to the increased repeatability of the results and significant reduction of the analysis time in comparison to the classical procedure of chromatogram development. Additionally, the new equipment allows use procedures that are not possible to run using the classic chromatogram development. In this paper, the results of manual and semi-automatic sample preparation with SFPE are compared and the possible application of this prototype device is discussed.

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Microdialysis Sampling as a Sample Preparation Method

Cited by 5 publications

References 178 publications

Analytical and Biological Methods for Probing the Blood-Brain Barrier

Analytical and Biological Methods for Probing the Blood-Brain Barrier

Analytical Considerations for Microdialysis Sampling

Solvent Front Position Extraction with Semi-Automatic Device as a Powerful Sample Preparation Procedure Prior to Quantitative Instrumental Analysis

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