Microdosimetry-based relative biological effectiveness calculations for radiotherapeutic electron beams: a FLUKA-based study

Chattaraj, Arghya; Selvam, T. Palani

doi:10.1007/s12194-021-00627-1

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…Given that reirradiations due to recurrent disease represent a significant proportion of intraoperative electron beam treatments, differences in biological damage, such as those found in this work, may not be irrelevant, especially in healthy organs where the dose received in previous treatments is close to the maximum tolerable dose limit. As already mentioned in the Introduction section of this paper, for the 6 MeV beam, Chattaraj et al [63] found that using the TDRA theory, RBE varied from 0.74 to 0.84, both values relative to 60 Co, over the range of water depths in our work (1.5-3 cm). The variation of RBE per mm is 0.0066 for HGS cells, similar to that measured in our study for the HaCat cell survival fraction (0.007 ∆SF/mm).…”

Section: Discussionsupporting

confidence: 75%

“…TDRA has been widely used to estimate the RBE of different types of particles [ 58 , 59 , 60 ], including electrons [ 61 , 62 ]. Chattaraj et al [ 63 ] calculated the RBE values based on TDRA and MKM with a FLUKA-MCTS code [ 64 ] for different therapeutic electron beams (6, 12 and 18 MeV). For the 6 MeV beam, the change in the RBE_TDRA value between the depths of 0.2 × R50 (R50 is the depth at which 50% of the maximum dose is reached) and 1.2 × R50 was around 18%.…”

Section: Introductionmentioning

confidence: 99%

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Dependence of Induced Biological Damage on the Energy Distribution and Intensity of Clinical Intra-Operative Radiotherapy Electron Beams

Colmenares

Carrión-Marchante

Martín

et al. 2023

IJMS

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The survival fraction of epithelial HaCaT cells was analysed to assess the biological damage caused by intraoperative radiotherapy electron beams with varying energy spectra and intensities. These conditions were achieved by irradiating the cells at different depths in water using nominal 6 MeV electron beams while consistently delivering a dose of 5 Gy to the cell layer. Furthermore, a Monte Carlo simulation of the entire irradiation procedure was performed to evaluate the molecular damage in terms of molecular dissociations induced by the radiation. A significant agreement was found between the molecular damage predicted by the simulation and the damage derived from the analysis of the survival fraction. In both cases, a linear relationship was evident, indicating a clear tendency for increased damage as the averaged incident electron energy and intensity decreased for a constant absorbed dose, lowering the dose rate. This trend suggests that the radiation may have a more pronounced impact on surrounding healthy tissues than initially anticipated. However, it is crucial to conduct additional experiments with different target geometries to confirm this tendency and quantify the extent of this effect.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Dependence of Induced Biological Damage on the Energy Distribution and Intensity of Clinical Intra-Operative Radiotherapy Electron Beams

Colmenares

Carrión-Marchante

Martín

et al. 2023

IJMS

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“…Herskind et al 20 measured the RBE of 10 MeV electrons to be 0.98 and 0.91 for MCF7 (breast cancer) and HUVEC (endothelium) cells respectively, suggesting that electrons across a range of energies have an RBE of > 1 when measuring cell survival. An RBE value of 0.84 for cell survival has also predicted for electron energies in the 6–18 MeV range using Monte Carlo modelling 21 . It should be noted that clinically, an RBE of 1 is used for electrons and has been for several decades.…”

Section: Discussionmentioning

confidence: 96%

First in vitro measurement of VHEE relative biological effectiveness (RBE) in lung and prostate cancer cells using the ARES linac at DESY

Wanstall,

Burkart,

Dinter

et al. 2024

Sci Rep

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Very high energy electrons (VHEE) are a potential candidate for radiotherapy applications. This includes tumours in inhomogeneous regions such as lung and prostate cancers, due to the insensitivity of VHEE to inhomogeneities. This study explores how electrons in the VHEE range can be used to perform successful in vitro radiobiological studies. The ARES (accelerator research experiment at SINBAD) facility at DESY, Hamburg, Germany was used to deliver 154 MeV electrons to both prostate (PC3) and lung (A549) cancer cells in suspension. Dose was delivered to samples with repeatability and uniformity, quantified with Gafchromic film. Cell survival in response to VHEE was measured using the clonogenic assay to determine the biological effectiveness of VHEE in cancer cells for the first time using this method. Equivalent experiments were performed using 300 kVp X-rays, to enable VHEE irradiated cells to be compared with conventional photons. VHEE irradiated cancer cell survival was fitted to the linear quadratic (LQ) model (R2 = 0.96–0.97). The damage from VHEE and X-ray irradiated cells at doses between 1.41 and 6.33 Gy are comparable, suggesting similar relative biological effectiveness (RBE) between the two modalities. This suggests VHEE is as damaging as photon radiotherapy and therefore could be used to successfully damage cancer cells during radiotherapy. The RBE of VHEE was quantified as the relative doses required for 50% (D0.5) and 10% (D0.1) cell survival. Using these values, VHEE RBE was measured as 0.93 (D0.5) and 0.99 (D0.1) for A549 and 0.74 (D0.5) and 0.93 (D0.1) for PC3 cell lines respectively. For the first time, this study has shown that 154 MeV electrons can be used to effectively kill lung and prostate cancer cells, suggesting that VHEE would be a viable radiotherapy modality. Several studies have shown that VHEE has characteristics that would offer significant improvements over conventional photon radiotherapy for example, electrons are relatively easy to steer and can be used to deliver dose rapidly and with high efficiency. Studies have shown improved dose distribution with VHEE in treatment plans, in comparison to VMAT, indicating that VHEE can offer improved and safer treatment plans with reduced side effects. The biological response of cancer cells to VHEE has not been sufficiently studied as of yet, however this initial study provides some initial insights into cell damage. VHEE offers significant benefits over photon radiotherapy and therefore more studies are required to fully understand the biological effectiveness of VHEE.

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“…5 × 10 7 electrons were tracked in the simulations. Similar approach was adopted by Chattaraj et al [45] for calculating microdosimetric distribution of radiotherapeutic electrons as a function of depth in water phantom.…”

Section: Calculations Of Microdosimetric Distributions In Topasmentioning

confidence: 99%

Microdosimetry-based quality factors for ISO reference photon and beta sources: TOPAS Monte Carlo study

et al. 2022

Self Cite

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In radiological protection, personnel dosimeters are calibrated in terms of operational quantities such as H p (10) and H p (0.07) against ISO reference photon and beta sources, respectively. H p (10) and H p (0.07) are defined at 1 cm and 0.07 μm depths in the ICRU-4 element tissue phantom. In present study, mean quality factor Q̅ is calculated at these depths using the TOPAS-based microdosimetric distributions at 1 μm site size and FLUKA-based Linear Energy Transfer (LET) dependent Q̅. The sources simulated are ISO reference narrow series X-rays, 137Cs and 147Pm, 85Kr, 90Sr/90Y and 106Ru/106Rh beta sources. Using the calculated microdosimetric distributions, Q̅ is calculated based on ICRP60 and ICRU40 recommendations, Keller-Hahn (KH) approximation, Microdosimetric Kinetic Model (MKM), Clonogenic Survival and Theory of Dual Radiation Action (TDRA). The study includes FLUKA-based Q̅ values calculated using Q(L) vs L relationship as per ICRP Report 60. The MKM, Clonogenic Survival-based RBE, ICRU40, TDRA and KH-based Q values of all the investigated sources are about unity. Depending on the source, microdosimetry-based Q̅ values using ICRP60 recommendations show significant difference from that calculated using other models. Q̅ values of 137Cs are unity, independent of the models.

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Microdosimetry-based relative biological effectiveness calculations for radiotherapeutic electron beams: a FLUKA-based study

Cited by 4 publications

References 23 publications

Dependence of Induced Biological Damage on the Energy Distribution and Intensity of Clinical Intra-Operative Radiotherapy Electron Beams

Dependence of Induced Biological Damage on the Energy Distribution and Intensity of Clinical Intra-Operative Radiotherapy Electron Beams

First in vitro measurement of VHEE relative biological effectiveness (RBE) in lung and prostate cancer cells using the ARES linac at DESY

Microdosimetry-based quality factors for ISO reference photon and beta sources: TOPAS Monte Carlo study

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