Microdosimetry of X-ray-irradiated gold nanoparticles

Garnica-Garza, H M

doi:10.1093/rpd/ncs278

Cited by 15 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other research, the energy deposition due to secondary electrons produced from GNPs and the microscopic dose enhancement around GNPs were quantified (Jones et al, 2010). The MC results obtained by McMahon (McMahon et al, 2011;Lechtman et al, 2011Lechtman et al, , 2013Garnica-Garza et al, 2013) are in good agreement with experimentally observed cell killing by the combination of X-rays and GNPs. In an experimental study (Rahman et al, 2009) where kilovolt X-ray radiation and megavolt electron radiation were used in the presence of GNPs in bovine aortic endothelial cells, it was found that the cell damage increases with the increase in the GNP concentration.…”

Section: Introductionsupporting

confidence: 66%

Effect of nanomaterials on the absorbed dose during an X-ray exposure

2016

View full text Add to dashboard Cite

This work is based on a numerical study using the Monte Carlo code Geant4 of an X-ray exposure of a human head containing a tumor at the center. Our principal goal was to investigate the effect of inserting nanomaterials into the tumor on the absorbed dose. Gold is the most popular nanomaterial used in nanomedicine. In our simulation, we also focused on the other nanomaterials platinum, gadolinium and silver. Our results show that gold and platinum increase the absorbed dose in the tumor by up to 55%; the most suitable X-ray energy is between 20 keV and 140 keV. Both of these nanomaterials present the same advantages in X-ray therapy. Moreover, gadolinium increases the absorbed dose by up to 50%, while silver increases the absorbed dose by up to 20%. However, for both of these nanomaterials, the best X-ray energy to use is between 20 keV and 80 keV.

show abstract

Section: Introductionsupporting

confidence: 66%

Effect of nanomaterials on the absorbed dose during an X-ray exposure

2016

View full text Add to dashboard Cite

show abstract

“…It has been reported that a secondary dose enhancement effect may result from the production of Auger electrons. 11 The low energy Auger electrons produced in the gold are able to travel beyond the extent of the GNP and cause ionization damage to the cell region to which the gold is attached (typically cell membrane, cytoplasm region, or cell nucleus, depending on the size of the individual GNP).…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo investigation of the increased radiation deposition due to gold nanoparticles using kilovoltage and megavoltage photons in a 3D randomized cell model

2013

View full text Add to dashboard Cite

show abstract

“…This change, in principle, would be beneficial in terms of the TCP as the high linear energy transfer of the electron cascade released from the high-atomic number atoms in the contrast agent would result in an increased lethality. 24 As the radiobiological parameters needed to account for the presence of the contrast agent in the GTV are not known, it is not possible to estimate the TCP for the treatment plans modeled in this work. We have shown, however, that when combining high-energy and CERT treatments, the OARs are receiving even lower maximum doses than when no contrast agent was used as part of the treatment.…”

Section: Discussionmentioning

confidence: 99%

Combined Megavoltage and Contrast-Enhanced Radiotherapy as an Intrafraction Motion Management Strategy in Lung SBRT

Coronado-Delgado

Garnica-Garza

2019

Technol Cancer Res Treat

View full text Add to dashboard Cite

Using Monte Carlo simulation and a realistic patient model, it is shown that the volume of healthy tissue irradiated at therapeutic doses can be drastically reduced using a combination of standard megavoltage and kilovoltage X-ray beams with a contrast agent previously loaded into the tumor, without the need to reduce standard treatment margins. Four-dimensional computed tomography images of 2 patients with a centrally located and a peripherally located tumor were obtained from a public database and subsequently used to plan robotic stereotactic body radiotherapy treatments. Two modalities are assumed: conventional high-energy stereotactic body radiotherapy and a treatment with contrast agent loaded in the tumor and a kilovoltage X-ray beam replacing the megavoltage beam (contrast-enhanced radiotherapy). For each patient model, 2 planning target volumes were designed: one following the recommendations from either Radiation Therapy Oncology Group (RTOG) 0813 or RTOG 0915 task group depending on the patient model and another with a 2-mm uniform margin determined solely on beam penumbra considerations. The optimized treatments with RTOG margins were imparted to the moving phantom to model the dose distribution that would be obtained as a result of intrafraction motion. Treatment plans are then compared to the plan with the 2-mm uniform margin considered to be the ideal plan. It is shown that even for treatments in which only one-fifth of the total dose is imparted via the contrast-enhanced radiotherapy modality and with the use of standard treatment margins, the resultant absorbed dose distributions are such that the volume of healthy tissue irradiated to high doses is close to what is obtained under ideal conditions

show abstract

Microdosimetry of X-ray-irradiated gold nanoparticles

Cited by 15 publications

References 10 publications

Effect of nanomaterials on the absorbed dose during an X-ray exposure

Effect of nanomaterials on the absorbed dose during an X-ray exposure

Monte Carlo investigation of the increased radiation deposition due to gold nanoparticles using kilovoltage and megavoltage photons in a 3D randomized cell model

Combined Megavoltage and Contrast-Enhanced Radiotherapy as an Intrafraction Motion Management Strategy in Lung SBRT

Contact Info

Product

Resources

About