Effect of nanomaterials on the absorbed dose during an X-ray exposure

Benlakhdar, F.; Dib, Anis Samy Amine; Belbachir, Ahmed Hafid

doi:10.1051/radiopro/2016073

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…To investigate this, the absorbed dose around a GNP was calculated as well as the secondary particle distributions inside and outside of the GNP, induced by monoenergetic electron beams with energies typical from the secondary electron spectra produced by x‐ray radiotherapy beams of 1, 10, and 100 keV. This selection of energies is comparable with recent studies of NP‐enhanced radiation treatments . Based on the results of this study, the application of the Geant4_DNA_AU models is discussed in terms of their impact on our understanding of the physical mechanism at the basis of GNP radioenhancement.…”

Section: Introductionmentioning

confidence: 76%

Geant4‐DNA track‐structure simulations for gold nanoparticles: The importance of electron discrete models in nanometer volumes

et al. 2018

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Improved physics models for gold are necessary to better model the impact of GNPs in radiotherapy via Monte Carlo simulations. We implemented discrete electron transport models for gold in Geant4 that is applicable down to 10 eV including the modeling of the full de-excitation cascade. It is demonstrated that the new model has a significant positive impact on particle transport simulations in gold volumes with submicron dimensions compared to the existing Livermore and Penelope condensed-history models of Geant4.

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Section: Introductionmentioning

confidence: 76%

Geant4‐DNA track‐structure simulations for gold nanoparticles: The importance of electron discrete models in nanometer volumes

et al. 2018

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Destruction of tumor mass by gadolinium-loaded nanoparticles irradiated with monochromatic X-rays: Implications for the Auger therapy

Matsumoto

Saitoh

Đoàn

et al. 2019

Sci Rep

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Synchrotron generated monochromatic X-rays can be precisely tuned to the K-shell energy of high Z materials resulting in the release of the Auger electrons. In this work, we have employed this mechanism to destruct tumor spheroids. We first loaded gadolinium onto the surface of mesoporous silica nanoparticles (MSNs) producing gadolinium-loaded MSN (Gd-MSN). When Gd-MSN was added to the tumor spheroids, we observed efficient uptake and uniform distribution of Gd-MSN. Gd-MSN also can be taken up into cancer cells and localize to a site just outside of the cell nucleus. Exposure of the Gd-MSN containing tumor spheroids to monochromatic X-ray beams resulted in almost complete destruction. Importantly, this effect was observed at an energy level of 50.25 keV, but not with 50.0 keV. These results suggest that it is possible to use precisely tuned monochromatic X-rays to destruct tumor mass loaded with high Z materials, while sparing other cells. Our experiments point to the importance of nanoparticles to facilitate loading of gadolinium to tumor spheroids and to localize at a site close to the nucleus. Because the nanoparticles can target to tumor, our study opens up the possibility of developing a new type of radiation therapy for cancer.

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A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes

et al. 2022

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Purpose: In the current study, we aimed to look into the macroscopic and microscopic dose enhancement effect of metallic nanoparticles in interstitial brachytherapy of gastric adenocarcinoma by Iodine-125 source using a nano-lattice model in MCNPX (2.7) and MCNP6.1 codes. Materials and methods: Based on a nano-lattice simulation model containing a radiation source and a tumor tissue with cellular compartments loaded with 7 mg/g spherical nanoparticles, the microscopic and macroscopic levels of energy deposition by the secondary electrons was estimated. Results: The results show that the values of macroscopic DEF are higher than microscopic DEF values and the macroscopic DEF values decrease by increasing the distance from the surface of brachytherapy source. Accordingly, it could be noted that gold nanoparticles have the highest radiosensitization effect among the other nanoparticles and the related DEF value is close to the resultant DEF values for bismuth nanoparticles. Moreover, the results revealed a remarkable discrepancy between the DEF and secondary electron spectra calculated by MCNPX (2.7) and MCNP6.1 codes, which could be justified by the difference in energy cut-off and electron transport algorithms of two codes. Conclusions: According to the both MCNPX (2.7) and MCNP6.1 outputs, it could be concluded that the presence of metallic nanoparticles in the tumor tissue of gastric adenocarcinoma increases the physical effectiveness of brachytherapy by I-125 source. This study aims to provide recommendations for future preclinical studies. Actually, the results presented herein give a physical view of radiosensitization potential of different metallic nanoparticles and could be considered in design of analytical and experimental radiosensitization studies in tumor regions using various radiotherapy modalities in the presence of heavy nanomaterials.

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Effect of nanomaterials on the absorbed dose during an X-ray exposure

Cited by 3 publications

References 25 publications

Geant4‐DNA track‐structure simulations for gold nanoparticles: The importance of electron discrete models in nanometer volumes

Geant4‐DNA track‐structure simulations for gold nanoparticles: The importance of electron discrete models in nanometer volumes

Destruction of tumor mass by gadolinium-loaded nanoparticles irradiated with monochromatic X-rays: Implications for the Auger therapy

A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes

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