Microelectrodes for in-vivo determination of pH

Zhou, Daojin

doi:10.1016/b978-012373738-0.50012-x

Cited by 18 publications

(12 citation statements)

References 145 publications

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“…However, glass fragility and size limitation impede in situ measurement in complex configurations and mediums (Ruffien-Ciszak et al, 2008;Huang et al, 2011) giving way to metal/metal oxide based pH sensors that are easily miniaturized and provide a welldefined metal/metal oxide interface (Daomin Zhou, 2008). More specifically, iridium oxide films can be formed by various physical and chemical methods (Ges et al, 2005) and exhibit many advantages among which high pH sensitivity, biocompatibility, chemical stability and fast response time (Daomin Zhou, 2008;Marzouk et al, 1998). IrO2 films have therefore found applications in cell metabolism monitoring in cell culture volumes (Ges et al, 2005) and microenvironmental studies (Bezbaruah and Zhang, 2002).…”

Section: Introductionmentioning

confidence: 99%

Integrated electrochemical biosensor based on algal metabolism for water toxicity analysis

Tsopela

Lale

Vanhove

et al. 2014

Biosensors and Bioelectronics

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An autonomous electrochemical biosensor with three electrodes integrated on the same silicon chip dedicated to the detection of herbicides in water was fabricated by means of silicon-based microfabrication technology. Platinum (Pt), platinum black (Pt Bl), tungsten/tungsten oxide (W/WO3) and iridium oxide (Pt/IrO2) working ultramicroelectrodes were developed. Ag/AgCl and Pt electrodes were used as reference and counter-integrated electrodes respectively. Physical vapor deposition (PVD) and electrodeposition were used for thin film deposition. The ultramicroelectrodes were employed for the detection of O2, H2O2 and pH related ions H3O(+)/OH(-), species taking part in photosynthetic and metabolic activities of algae. By measuring the variations in consumption-production rates of these electroactive species by algae, the quantity of herbicides present at trace level in the solution can be estimated. Fabricated ultramicroelectrodes were electrochemically characterized and calibrated. Pt Black ultramicroelectrodes exhibited the greatest sensitivity regarding O2 and H2O2 detection while Pt/IrO2 ultramicroelectrodes were more sensitive for pH measurement compared to W/WO3 ultramicroelectrodes for pH measurement. Bioassays were then conducted to detect traces of Diuron herbicide in water samples by evaluating disturbances in photosynthetic and metabolic activities of algae caused by this herbicide.

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Section: Introductionmentioning

confidence: 99%

Integrated electrochemical biosensor based on algal metabolism for water toxicity analysis

Tsopela

Lale

Vanhove

et al. 2014

Biosensors and Bioelectronics

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“…The pH value can be used as an indicator for disease diagnostics, medical treatment optimization, and monitoring of biochemical and biological processes [75]. Nevertheless, the integration of pH sensing systems into the next generation of wearable devices requires a different architecture than currently used in typical glass-type electrodes and a minimal electrode size [76].…”

Section: Ph Sensorsmentioning

confidence: 99%

Electrodeposition of WO3 Nanoparticles for Sensing Applications

Santos¹,

Neto²,

Crespo³

et al. 2015

Electroplating of Nanostructures

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The motivation of using metal oxides is mainly due to its charge storage capabilities, and electrocatalytic, electrochromic and photoelectrochemical properties. But comparing with bulk, nanostructured materials present several advantages related with the spatial confinement, large fraction of surface atoms, high surface energy, strong surface adsorption and increased surface to volume ratio, which greatly improves the performances of these materials. The deposition of this materials can be accomplished by a variety of physical and chemical techniques but nowadays, electrodeposited metal oxides are generally used in both laboratories and industries due to the flexibility to control structure and morphology of the oxide electrodes combined with a reduced cost. Tungsten oxide (WO 3 ) is a well-studied semiconductor and is used for several applications as chromogenic material, sensor and catalyst. The major important features is its low cost and availability, improved stability, easy morphologic and structural control of the nanostructures, reversible change of conductivity, high sensitivity, selectivity and biocompatibility. For the electrodeposition of WO 3 , more than one method can be adopted: electrodeposition from a precursor solution, anodic oxidation, and electrodeposition of already produced nanoparticles; however, in this case the mechanism of the electrodeposition is not fully understood. In this chapter, a review of the latest published work of electrodeposited nanostructured metal oxides is provided to the reader, with a more detailed explanation of WO 3 material applied in sensing devices.

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“…Given the interest in blood pH monitoring, many measurement methods and measuring systems have been presented in the literature in the last years i.e. [1], [6]- [14]. However, as discussed in more detail in our recent paper [5], nowadays no measurement method has been able to provide safe, economical, accurate and reliable estimates of pH in the bloodstream to be used routinely during ECC treatments, thus blood pH is generally not monitored during ECC treatments.…”

Section: Introductionmentioning

confidence: 99%

Performances and Robustness of a Fluorescent Sensor for Nearly Neutral pH Measurements in Healthcare

Cattini

Truzzi

Accorsi

et al. 2020

IEEE Trans. Instrum. Meas.

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The capability to measure pH is fundamental in many fields ranging from healthcare and agri-food, to chemistry and industrial applications. In medicine, the possibility of in-line and real-time monitoring critical care analytes such as pH is recognized to provide relevant information for the diagnosis and treatment of a variety of disorders and would be of considerable support for the management of extracorporeal (blood) circulation (ECC). In this paper, we theoretically and experimentally investigate the performances and the robustness of a fluorescent sensor we recently proposed for the in-line and real-time monitoring of blood pH in extracorporeal circulation (ECC). Thanks to the low-cost and biocompatibility, the proposed sensor can be used for the in-line and real-time monitoring of the pH of fluids especially in applications such as healthcare where safe and low-cost disposable are required for all parts in contact with the patient. The reported results demonstrate that the proposed sensor allows achieving significant robustness to unevennesses in the production process of the sensing element.

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Microelectrodes for in-vivo determination of pH

Cited by 18 publications

References 145 publications

Integrated electrochemical biosensor based on algal metabolism for water toxicity analysis

Integrated electrochemical biosensor based on algal metabolism for water toxicity analysis

Electrodeposition of WO3 Nanoparticles for Sensing Applications

Performances and Robustness of a Fluorescent Sensor for Nearly Neutral pH Measurements in Healthcare

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