Microemulsified Cyclosporine‐Based Immunosuppression for the Prevention of Acute Renal Allograft Rejection in Unrelated Dogs: Preliminary Experimental Study

Abstract

Immunosuppression using MCsA, azathioprine, and prednisolone may be effective in preventing acute renal allograft rejection in unrelated, mongrel dogs. This triple drug protocol is cost-effective and was easy to administer. Further investigation is warranted to minimize toxic effects and to determine the efficacy of prophylactic renal biopsies to detect and treat subclinical acute/active rejection.

Successful Management of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Pneumonia after Kidney Transplantation in a Dog

“…Most of these studies have focused on the effectiveness of immunosuppression protocols, surgical techniques and the survival of the animal recipients [4, 9, 17]. Although some reports have briefly described successful recovery from bacterial complications that were not due to MDR strains, others have presented cases in which the infections did not respond well to treatment with antimicrobials [9, 11].…”

Multifocal papular deep bacterial pyoderma in a Boxer dog caused by Pseudomonas aeruginosa

“…Corticosteroids and cyclosporine had been previously administered to the dog in this case report, but corticosteroids had been ceased and cyclosporine doses increased 2 months before the development of pseudomonal pyoderma. The recommended antiinflammatory dose rate of cyclosporine for the treatment of canine atopic dermatitis (5 mg/kg/day) 10 is substantially lower than that used for immunosuppression following organ transplantation (20 mg/kg/day) 12 . At the antiinflammatory dose, increased frequency of bacterial infections with cyclosporine administration in dogs has not been reported, 13,14 and one study suggested a decreased frequency of skin infection in the first 3 to 4 months during treatment 15 .…”

Gingival Overgrowth in Dogs Associated with Clinically Relevant Cyclosporine Blood Levels: Observations in a Canine Renal Transplantation Model

“…Three dogs were subsequently excluded as candidates because of positive cross‐match reactions of erythrocytes or lymphocytes. After matches were established, a single kidney was exchanged between 2 dogs for transplantation in the external iliac region of each recipient using standard techniques under general anesthesia followed by removal of the remaining native kidneys 20 . Dogs that developed gingival lesions were termed responders and those that had normal appearing gingiva were termed non‐responders.…”

“…Immediately after surgery, prednisolone (1 mg/kg/day orally; Solondo, Yuhan Pharmaceutical Co, Seoul, Korea) was included in the immunosuppressive drug regimen. Prednisolone dose was reduced 1 month after surgery and discontinued after 3 months 20 …”