Microemulsion versus emulsion as effective carrier of hydroxytyrosol

Chatzidaki, Maria D.; Arik, Nehir; Monteil, Julien; Papadimitriou, Vassiliki; Leal-Calderón, Fernando; Xenakis, Aristotelis

doi:10.1016/j.colsurfb.2015.04.053

Cited by 28 publications

(37 citation statements)

References 32 publications

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“…Chatzidaki [ 18 ] reported that W/O microemulsions and emulsions, as the carrier of HT, were successfully formulated with the addition of emulsifiers based on medium chain triglycerides. In the further research, findings were presented in [ 32 ] that indicated that the amounts of surfactants and emulsifiers both affected gastrointestinal lipolysis efficiency.…”

Section: Resultsmentioning

confidence: 99%

“…One of the strategies to overcome the rapid release of HT and increasing its pharmacological bioactivity in vivo is to encapsulate it in a suitable delivery system [ 17 ]. Recently, water in oil (W/O) emulsions, microemulsions [ 18 ] and nanoparticles [ 19 ] were shown to be effective carriers of HT, as a natural antioxidant, which retained its scavenging ability inhibiting approximately 90% of the free radical within the first 5 min of incubation. In addition, liposomes, a directed drug carrier for targeted drug-delivery systems, is a new drug formulation generally capable of encapsulating lipid-soluble substances [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Preparation, Characterization, and Antioxidant Activity Evaluation of Liposomes Containing Water-Soluble Hydroxytyrosol from Olive

Yuan

Qin

et al. 2017

Molecules

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Due to the multiple hydroxyl groups in its structure, hydroxytyrosol (HT) is very sensitive to air and light and has very strong instability and hydrophilicity that affect its biological activity. This study attempted to prepare liposomes containing water-soluble HT to improve the bioavailability and biocompatibility of the target drug. The preparation process factors (temperature, mass ratio of phospholipid (PL) and cholesterol (CH), Tween-80 volume, HT mass) were studied and response surface methodology (RSM) was applied to optimize the conditions. The results demonstrated that by using a temperature of 63 °C, mass ratio of PL and CH 4.5:1, HT mass 5 mg and Tween-80 volume of 6 mL, HT liposomes with an encapsulation efficiency (EE) of 45.08% were prepared. It was found that the particle sizes of the HT liposomes were well distributed in the range of 100–400 nm. Compared to free HT, prepared HT liposomes had better stability and a distinct slow release effect in vitro. Besides, HT liposomes presented better DPPH radical scavenging activity than free HT, which could be due to the fact that HT was encapsulated fully inside the liposomes. In addition, the encapsulation mechanism of HT was evaluated. In summary, the results indicated that HT liposome could enhance the antioxidant activity and was a promising formulation for prolonging the biological activity time of the target drug.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Antioxidant Activity Evaluation of Liposomes Containing Water-Soluble Hydroxytyrosol from Olive

Yuan

Qin

et al. 2017

Molecules

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“…An effective carrier system was developed for the hydroxytrosol by utilizing the pseudo-ternary phase. The pseudoternary phase diagram consist of miglyol 810 (oil phase) with the surfactant phase lecithin [59]. Another very interesting study is reported that drug having low partition coefficient improve BA through constructing of the pseudo ternary phase diagrams consists of Cremophor RH 40 (Macrogolglycerol hydroxystearate), Capryol 90 (propylene glycol monocaprylate) and Transcutol HP (diethylene glycol monoethyl ether) and study revealed about BA enhancement from as compare with plain drug solution [60].…”

Section: Phase Diagram Of Les Systemsmentioning

confidence: 98%

Therapeutic challenges in ocular delivery of lipid based emulsion

Tiwari

Pandey

Asati

et al. 2018

Egyptian Journal of Basic and Applied Sciences

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In the last decade, lipid based emulsions (LEs) have emerged as a novel tool in ophthalmic drug delivery from the aspect of improved bioavailability (BA). Recent research is focuses on two main approaches for BA improvement i.e., by enhancing the corneal permeability and increasing the retention time of drug on the ocular surface. The LEs have great potential to delivery hydrophobic drug because drug molecules get dissolve in oil globule and main advantage associated are reduced toxic effect and improved self-life of drug molecule. Ophthalmic drug delivery is always an interesting and challenging task for the pharmacologists and formulation scientists due to the unique structure of eye. Development of drug delivery system and its delivery to target receptor of the eye is very difficult for scientists due to the strong defense mechanism of eye. In this review, the focus is to explore key concepts of ophthalmic drug delivery with emphasis on the defense mechanisms, design considerations, and safety assessment of LEs for the ocular drug delivery.

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“…The EPR signal of the radical is dependent on the environment around the radical, thus structural information can be acquired. The radical probes could be organic [90][91][92][93][94] or inorganic [13]. The X-band EPR spectra of aqueous solutions containing extracts of green or black tea and Cu II showed the formation of six complexes, probably of Cu II with amino acids.…”

Section: Addition Of Radicalsmentioning

confidence: 99%

EPR Methods Applied on Food Analysis

Drouza¹,

Spanou²,

Keramidas³

2019

Topics From EPR Research

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An overview of the different methodologies developed so far for the investigation of paramagnetic species in foods is presented. Electron paramagnetic resonance spectroscopy (EPR), also known as electron spin resonance spectroscopy (ESR), is the primary technique toward the development of methods for the exploration of EPR-sensitive species, such as free radicals, reactive oxygen species (ROS), nitrogen reactive species (NRS), and C-centered radicals and metal ions. These methods aim for: (a) quantification of radical species, (b) exploration of redox chemical reaction mechanisms in foods, (c) assessment of the antioxidant capacity of food, and (d) food quality, stability, and food shelf life. For these purposes, different radical initiations and detections have been used in foods depending on both the chemistry of the target system and the kind of information required, listed in: the induction of radicals by (a) microwave, UV, or γ-radiation; (b) heating; (c) addition of metals; and (d) use of oxidants.

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Microemulsion versus emulsion as effective carrier of hydroxytyrosol

Cited by 28 publications

References 32 publications

Preparation, Characterization, and Antioxidant Activity Evaluation of Liposomes Containing Water-Soluble Hydroxytyrosol from Olive

Preparation, Characterization, and Antioxidant Activity Evaluation of Liposomes Containing Water-Soluble Hydroxytyrosol from Olive

Therapeutic challenges in ocular delivery of lipid based emulsion

EPR Methods Applied on Food Analysis

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