Th e evolution of today's sensors based on the micro/nano electromechanical systems (MEMS/NEMS) happened due to the revolutions in the well-established microelectronics technology. Th ough silicon is considered to be the primary material in microelectronics and hence in MEMS, many classes of MEMS devices have been realized using other potential materials like polymers. A class of MEMS sensors named nanomechanical cantilevers fi nd applications in the realization of many physical, chemical, and biological sensors. Improved sensitivity, reliability and also cost eff ectiveness of such sensor platforms have been achieved by the use of polymer materials, along with the employment of smart and compatible transduction techniques. Th is chapter summarizes our research work on development of polymer MEMS cantilever sensor platforms with four novel integrated electrical transduction mechanisms. In these techniques, the mechanical parameters of the polymer (SU-8) MEMS sensors can be translated into electrical output using (1) SU-8/CB nanocomposite (a piezoresistive approach), (2)integrated organic fi eld eff ect transistor of CantiFET (a strain sensitive transistor approach), (3) integrated Al doped ZnO TFT (a strain sensitive thin fi lm transistor approach) or (4) SU-8/ ZnO nanocomposite ( a piezoelectric approach).