Microfilaria Coexistent with Fibroadenoma – An Unusual Association

Sane, Kavita; Bholay, Sandhya Unmesh; Bari, Vaibhav; Kulkarni, Manoj N.

doi:10.7860/jcdr/2015/15944.6647

Cited by 3 publications

(6 citation statements)

References 4 publications

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“…[4][5][6][7][8][9][10][11][12][13]20] They have been reported in isolation [6,8,9,10,11,12] and in association with breast abscess, [4] granulomas, [11,12] benign proliferative disease, [5] fibroadenoma, [4,19] and adenocarcinoma. [7] Two such cases were reported in this study.…”

Section: Resultsmentioning

confidence: 99%

Role of Cytology in Detection of Unsuspected Carriers of Microfilariae: A Retrospective Study in National Capital Region (NCR), India

Dubey¹,

Mishra²,

Srivastav³

et al. 2018

APALM

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Background: Filariasis, a global problem, is a major public health issue in India. Despite its high incidence, it is unusual to detect microfilaria in cytological smears, though unexpected detection of microfilariae in fine needle aspiration cytology (FNAC), exfoliative and fluid cytology have been reported previously. The study analyzed the role of cytology in detection of asymptomatic carriers of microfilariae. Methods:This was a retrospective, observational study and included cases of filariasis from cytological records spanning five years. The epidemiological, clinical, hematologic and radiologic details were noted. The slides were retrieved and examined. Descriptive statistical analysis was utilized.Result: Filariasis was diagnosed in 0.03% of the total cytology cases studied during the period, constituting 0.04% of FNACs (two cases of inguino-scrotal swellings, two of breast lumps, one of thyroid swelling) and 0.02% of cervicovaginal smears (two cases). None of them was clinically suspected to be filariasis. Radiological examination was also misleading. None of the cases demonstrated raised leukocytosis or microfilaremia and eosinophilia was present in 3 cases (42.9%). Apart from microfilariae of Wuchereria bancrofti, eggs were present in one case. This was associated with inflammation in all cases, cell adherence in 42.9% and coexistent hyperplastic and neoplastic conditions in 57.1% cases. Conclusion:The detection of microfilariae in cytological material in the absence of clinical, radiologic or hematologic suspicion, in an area of relatively low prevalence of filaria, points to the need for a high index of suspicion and careful screening of all smears, as cytology may play an important role in the diagnosis of asymptomatic carriers of microfilariae.

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Section: Resultsmentioning

confidence: 99%

Role of Cytology in Detection of Unsuspected Carriers of Microfilariae: A Retrospective Study in National Capital Region (NCR), India

Dubey¹,

Mishra²,

Srivastav³

et al. 2018

APALM

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“…Also, there may or may not be presence of eosinophilia, foreign body giant cell and granulomatous reaction in cytological smears which can aids in the diagnosis. 1,6,7 Several authors have proposed a hypothesis explaining the presence of microfilaria in a malignant lesion. In malignancy, there is obstruction of vascular and lymphatic channels causing extravasation of blood and lymph which may releases microfilaria into the tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, while performing FNAC, there may be damage to vessels leading to release of microfilariae into the tissues. [6][7][8] It seems that filariasis does not alter the clinical presentation of a tumour and a patient may, of course, suffer with subclinical filariasis before developing such tumour. The drug of choice for filariasis is ivermectin which is effective against both microfilaria and adult worms.…”

Section: Discussionmentioning

confidence: 99%

Cytological diagnosis of microfilaria coexistent with suspected malignancy of breast and ovary in a young pregnant female

et al. 2022

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“…Lymphatic blockage and lymphatic obstruction resulting in lymphedema and lymphadenitis are usual mode of presentation of filariasis however extranodal filariasis is rare and has been reported in uncommon sites including skin and soft tissue swelling, breast, thyroid nodule, salivary gland, cervicovaginal smear, ovarian cyst, effusion fluids, urine, bronchial, laryngeal and pharyngeal brushings. 7,10,11 Extravasation may explain the presence of microfilariae in pericardial fluid, breast cyst fluid and bronchial aspirate. The parasites circulate in lymphatic and vascular compartments but the presence of filarial organism in tissue fluids and exfoliated surface material probably occurs owing to conditions causing lymphovascular obstruction resulting in extravasations of blood and release of microfilariae.…”

Section: Discussionmentioning

confidence: 99%

“…Species identification is often difficult in the adult worm, but it is possible on the basis 2,5,6 The common manifestations of filariasis are elephantiasis, chronic lymphedema, epididymitis, funiculitis and lymphadenitis. 7 Filariasis in the form of subcutaneous swelling is a relatively uncommon event. 2 We report a case of subcutaneous upper extremity swelling caused by W bancrofti which was diagnosed by demonstration of microfilaria in cytological smears.…”

Section: Introductionmentioning

confidence: 99%

Filariasis presenting as an upper arm swelling – an unusual presentation

et al. 2018

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Filariasis is a chronic disabling parasitic disease causing a major public health problem in tropical areas of Southeast Asia. It is endemic in India, China, Nepal, Indonesia, parts of Asia and Africa. In Southeast Asia it is caused mainly by W. bancrofti and Brugia species. Microfilaria is known to be present in cytology smears prepared from swelling at various sites and also in different body fluids. However, upper arm swelling as a clinical presentation of filariasis is a very rare event. If cytology smears are screened with high index of suspicion in this group of otherwise asymptomatic patients, early institution of proper treatment can both prevent the complication of the disease as well as break the chain of transmission from healthy carriers.

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Microfilaria Coexistent with Fibroadenoma – An Unusual Association

Cited by 3 publications

References 4 publications

Role of Cytology in Detection of Unsuspected Carriers of Microfilariae: A Retrospective Study in National Capital Region (NCR), India

Role of Cytology in Detection of Unsuspected Carriers of Microfilariae: A Retrospective Study in National Capital Region (NCR), India

Cytological diagnosis of microfilaria coexistent with suspected malignancy of breast and ovary in a young pregnant female

Filariasis presenting as an upper arm swelling – an unusual presentation

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