Microflow chemistry and its electrification for sustainable chemical manufacturing

Chen, Tai-Ying; Hsiao, Yung Wei; Baker-Fales, Montgomery; Cameli, Fabio; Dimitrakellis, Panagiotis; Vlachos, Dionisios G.

doi:10.1039/d2sc01684b

Cited by 16 publications

(12 citation statements)

References 345 publications

(651 reference statements)

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“…T-junctions can be easily scaled-up in industrial processes. The interplay of viscous, interfacial, inertial, and gravitational forces creates multiple flow patterns ,, identified based on standard definitions; see SI. ,,,, For the mass transfer rate study, an aqueous phase consisting of HMF and an organic phase free of HMF are sent to the T junction, and HMF is transferred from the aqueous phase to the organic phase.…”

Section: Systems and Methodsmentioning

confidence: 99%

Effect of Scale-Up on Mass Transfer and Flow Patterns in Liquid–Liquid Flows Using Experiments and Computations

Mittal,

Bhattacharyya,

Marino

et al. 2023

Ind. Eng. Chem. Res.

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Liquid−liquid microchannels have high mass transfer rates but low throughput. To increase productivity, they can be scaled up by increasing the diameter. Therefore, predicting flow patterns and mass transfer rates while accounting for solvent effects as the diameter varies is crucial; however, this topic is currently lacking in the literature. We develop random forest and symbolic genetic regression machine learning (ML) models to predict flow patterns and the mass transfer rate, respectively, using a combination of our experimental and computational fluid dynamics (CFD) data and literature-mined data, while accounting for the effects of solvent properties and channel diameter. This enables rapid prediction for efficient scale-up of microchannels to millichannels. To minimize the number of CFD simulations and maximize the model accuracy, we employ active learning techniques. Furthermore, we quantify the uncertainty of the ML models built on the hybrid data.

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Section: Systems and Methodsmentioning

confidence: 99%

Effect of Scale-Up on Mass Transfer and Flow Patterns in Liquid–Liquid Flows Using Experiments and Computations

Mittal,

Bhattacharyya,

Marino

et al. 2023

Ind. Eng. Chem. Res.

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“…In the past few decades, droplet microfluidics technology has developed rapidly, and it has been used in the design of microreactors because of its strong controllability in performing various operations ( Chen et al, 2022 ; Jobdeedamrong et al, 2023 ). Due to their compatibility with many chemical and biological reagents, droplet microfluidic systems have been used to prepare complex reactants and special materials, such as polymer particles ( Juang and Chiu, 2022 ), microgel particles ( Rojek et al, 2022 ), and nanoparticles ( Küçüktürkmen et al, 2022 ; Maged et al, 2022 ; Niculescu et al, 2022 ).…”

Section: Droplet Generation and Single-cell Encapsulationmentioning

confidence: 99%

Droplets microfluidics platform—A tool for single cell research

Cheng

et al. 2023

Front. Bioeng. Biotechnol.

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Cells are the most basic structural and functional units of living organisms. Studies of cell growth, differentiation, apoptosis, and cell-cell interactions can help scientists understand the mysteries of living systems. However, there is considerable heterogeneity among cells. Great differences between individuals can be found even within the same cell cluster. Cell heterogeneity can only be clearly expressed and distinguished at the level of single cells. The development of droplet microfluidics technology opens up a new chapter for single-cell analysis. Microfluidic chips can produce many nanoscale monodisperse droplets, which can be used as small isolated micro-laboratories for various high-throughput, precise single-cell analyses. Moreover, gel droplets with good biocompatibility can be used in single-cell cultures and coupled with biomolecules for various downstream analyses of cellular metabolites. The droplets are also maneuverable; through physical and chemical forces, droplets can be divided, fused, and sorted to realize single-cell screening and other related studies. This review describes the channel design, droplet generation, and control technology of droplet microfluidics and gives a detailed overview of the application of droplet microfluidics in single-cell culture, single-cell screening, single-cell detection, and other aspects. Moreover, we provide a recent review of the application of droplet microfluidics in tumor single-cell immunoassays, describe in detail the advantages of microfluidics in tumor research, and predict the development of droplet microfluidics at the single-cell level.

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“…One of the first microreactor studies under the DuPont-MIT alliance aimed to provide on-demand production of hazardous reactive intermediates; 177 since then, microreactors, minireactors, and flow reactors have been developed for on-demand production of reactive intermediates, parallelization of hazardous chemistries, and reduction in reaction volume by providing continuous alternatives to conventional batchwise processing. 178 Most recently, efforts to develop distributed, modular chemical processing have driven interest in electrification of 179 the chemical industry to enable decarbonization. Chemical reactors typically require operating ranges from 100 to 1000 °C, traditionally achieved either directly or indirectly (via additional steam utility infrastructure or furnaces) through combustion of fuels.…”

Section: Nonstandard Reactor Typesmentioning

confidence: 99%

Vision 2050: Reaction Engineering Roadmap

Bollini,

Diwan,

Gautam

et al. 2023

ACS Eng. Au

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This perspective provides the collective opinions of a dozen chemical reaction engineers from academia and industry. In this sequel to the “Vision 2020: Reaction Engineering Roadmap,” published in 2001, we provide our opinions about the field of reaction engineering by addressing the current situation, identifying barriers to progress, and recommending research directions in the context of four industry sectors (basic chemicals, specialty chemicals, pharmaceuticals, and polymers) and five technology areas (reactor system selection, design and scale-up, chemical mechanism development and property estimation, catalysis, nonstandard reactor types, and electrochemical systems). Our collective input in this report includes numerous recommendations regarding research needs in the field of reaction engineering in the coming decades, including guidance for prioritizing efforts in workforce development, measurement science, and computational methods. We see important roles for reaction engineers in the plastics circularity challenge, decarbonization of processes, electrification of chemical reactors, conversion of batch processes to continuous processes, and development of intensified, dynamic reaction processes.

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Microflow chemistry and its electrification for sustainable chemical manufacturing

Abstract: Sustainability is vital in solving global societal problems. Still, it requires a holistic view by considering renewable energy and carbon sources, recycling waste streams, environmentally friendly resource extraction and handling,...

Cited by 16 publications

References 345 publications

Effect of Scale-Up on Mass Transfer and Flow Patterns in Liquid–Liquid Flows Using Experiments and Computations

Effect of Scale-Up on Mass Transfer and Flow Patterns in Liquid–Liquid Flows Using Experiments and Computations

Droplets microfluidics platform—A tool for single cell research

Vision 2050: Reaction Engineering Roadmap

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