2023
DOI: 10.1016/j.talanta.2022.123766
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Microfluidic amperometric immunosensor based on porous nanomaterial towards claudin7 determination for colorectal cancer diagnosis

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Cited by 17 publications
(7 citation statements)
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“…In comparison with a previous work [ 32 ], our microfluidic immunosensor based on the CNF/GNP nanocomposite platform for antibody monoclonal immobilization presents relevant advantages, such as its high surface and biocompatibility, miniaturization and easy handling, low-cost production, and short time analysis. In another recently published work [ 33 ], we developed an amperometric microfluidic immunosensor for claudin7 cancer biomarker determination in circulating extracellular vesicles (EVs) in colorectal cancer patient’s samples. Claudin7 is a relevant biomarker for colorectal cancer diagnosis and prognosis.…”
Section: Resultsmentioning
confidence: 99%
“…In comparison with a previous work [ 32 ], our microfluidic immunosensor based on the CNF/GNP nanocomposite platform for antibody monoclonal immobilization presents relevant advantages, such as its high surface and biocompatibility, miniaturization and easy handling, low-cost production, and short time analysis. In another recently published work [ 33 ], we developed an amperometric microfluidic immunosensor for claudin7 cancer biomarker determination in circulating extracellular vesicles (EVs) in colorectal cancer patient’s samples. Claudin7 is a relevant biomarker for colorectal cancer diagnosis and prognosis.…”
Section: Resultsmentioning
confidence: 99%
“…Enzyme activity-related tumor markers, such as adenosine triphosphate (ATP), 85 acetylcholinesterase, 86 protein tyrosine kinase-7 (PTK7), 87 lymphocyte activation protein gene-3 (LAG-3), 88 nuclear matrix protein-22 (NMP-22), 89 and α-fetoprotein (AFP), 90 are commonly studied. Disease-specific antigens, including carbohydrate antigen 19-9 (CA19-9), prostate-specific antigen (PSA), 91 carcinoma antigen 125 (CA125), 92 colorectal cancer biomarker (CLD7), 93 and CA242, 94 are also crucial in this context. Analytical tests possessing sensitivity, specificity, reliability, and rapidity are pivotal in measuring these biomarkers and play a crucial role in the cancer detection process.…”
Section: Mof-based Biosensorsmentioning
confidence: 99%
“…Their results showcased a wide linear detection range (0.0001–5 ng mL −1 ) and a low detection limit of 0.00453 ng mL −1 . Recently, Ortega et al 93 synthesized MIL-125-NH 2 coated with anti-CLD7 monoclonal antibody on a material using a microfluidic amperometric immunosensor device to detect the colorectal cancer biomarker. In this study, electrochemical immunosensors were used due to their rapidity, specificity, and feasibility.…”
Section: Mof-based Biosensorsmentioning
confidence: 99%
“…Francisco and his team presented a microfluidic amperometric immunosensor assay for detecting the biomarker claudin7 (CLD7). The results showed that the detection range of the detector was 2–1000 pg mL −1 , and the detection limit of CLD7 could reach 0.1 pg mL −1 under optimal conditions [ 94 ].…”
Section: Biomarkersmentioning
confidence: 99%