Microfluidic assembly of food-grade delivery systems: Toward functional delivery structure design

Feng, Yiming; Lee, Youngsoo

doi:10.1016/j.tifs.2019.02.054

Cited by 32 publications

(12 citation statements)

References 187 publications

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“…The decrease of viscosity after microfluidization and ultrasonication was attributed to the molecular size reduction which was closely related to the decrease of molecular weight and polydispersity [24] , [25] . According to the Mark–Houwink–Sakurada equation (3) , the viscosity of a solution is positively correlated with the molecular weight [26] .

where η was the intrinsic viscosity (L/g); k and α were constants depending on the solution and temperature; M was the viscosity-average molecular weight.…”

Section: Resultsmentioning

confidence: 99%

Citrus pectin modified by microfluidization and ultrasonication: Improved emulsifying and encapsulation properties

Wang

Feng

Chen

et al. 2021

Ultrasonics Sonochemistry

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where η was the intrinsic viscosity (L/g); k and α were constants depending on the solution and temperature; M was the viscosity-average molecular weight.…”

Section: Resultsmentioning

confidence: 99%

Citrus pectin modified by microfluidization and ultrasonication: Improved emulsifying and encapsulation properties

Wang

Feng

Chen

et al. 2021

Ultrasonics Sonochemistry

Self Cite

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“…Microfluidics is an emerging technology that is receiving more and more attention because it can be used to manufacture precisely controlled food-grade functional delivery systems. 14 Microfluidics provides a relatively simple and consistent method to overcome the cumbersome steps faced by conventional preparation processes to synthesize nanoparticles of uniform size with better release properties. For instance, polymer nanoparticles made by microfluidics showed a smaller size and lower polydispersity index (PDI) than those made by mass bulk mixing.…”

Section: ■ Introductionmentioning

confidence: 99%

Microfluidic Fabrication of pH-Responsive Nanoparticles for Encapsulation and Colon-Target Release of Fucoxanthin

Liang

Zhao

et al. 2021

J. Agric. Food Chem.

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Improving the stability of fucoxanthin in the gastrointestinal tract is an important approach to enhance its oral bioavailability. The study proposed a new microfluidic device allowing for the synthesis of a structurally well-defined nanoscale delivery system with a uniform size for encapsulation and colon-target release of fucoxanthin. The rapid mixing in the microfluidic channel ensured that the mixing time was shorter than the aggregation time, thus realizing the controllable control of the coprecipitation of fucoxanthin and shellac polymer. In vitro digestion tests showed that a pH stimulus-responsive release of fucoxanthin from FX/SH NPs was observed under alkaline pH conditions. The fluorescence colocalization imaging indicated that FX/SH NPs did not affect the intestine function and had a protective effect on Caco-2 cells damaged by H2O2 by enhancing their antioxidant capacity. Overall, this work illustrated the promise of using a microfluidic approach to fabricate the biomimetic nanodelivery system for better biocompatibility and targeting efficacy.

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“…However, to reduce costs and enable a more immediate detection result, it is desirable to analyze the milk quality at the point of production using simple, low-cost methods. As a result, the development of microfluidic platforms for the detection and analysis of milk samples has attracted significant interest in recent years [ 49 , 50 , 51 ]. This section of the review describes some of the most significant lab-on-a-chip and lab-on-paper proposals reported in the literature over the past five years for the detection of some of the most common contaminants in milk, namely aflatoxins, antibiotics, drugs, melamine, and foodborne pathogens.…”

Section: Microfluidic Platforms For Milk Sample Analysismentioning

confidence: 99%

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Lee

Kung

et al. 2021

Micromachines

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Milk is a necessity for human life. However, it is susceptible to contamination and adulteration. Microfluidic analysis devices have attracted significant attention for the high-throughput quality inspection and contaminant analysis of milk samples in recent years. This review describes the major proposals presented in the literature for the pretreatment, contaminant detection, and quality inspection of milk samples using microfluidic lab-on-a-chip and lab-on-paper platforms in the past five years. The review focuses on the sample separation, sample extraction, and sample preconcentration/amplification steps of the pretreatment process and the determination of aflatoxins, antibiotics, drugs, melamine, and foodborne pathogens in the detection process. Recent proposals for the general quality inspection of milk samples, including the viscosity and presence of adulteration, are also discussed. The review concludes with a brief perspective on the challenges facing the future development of microfluidic devices for the analysis of milk samples in the coming years.

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Microfluidic assembly of food-grade delivery systems: Toward functional delivery structure design

Cited by 32 publications

References 187 publications

Citrus pectin modified by microfluidization and ultrasonication: Improved emulsifying and encapsulation properties

Citrus pectin modified by microfluidization and ultrasonication: Improved emulsifying and encapsulation properties

Microfluidic Fabrication of pH-Responsive Nanoparticles for Encapsulation and Colon-Target Release of Fucoxanthin

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

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