Microfluidic assisted synthesis of PLGA drug delivery systems

Rezvantalab, Sima; Moraveji, Mostafa Keshavarz

doi:10.1039/c8ra08972h

Cited by 109 publications

(66 citation statements)

References 124 publications

(149 reference statements)

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“…The ultimate size of particles depends on frequency, amplitude and the sonication process 4 . Microfluidics have been described as systems that process or manipulate micro- or nano-liter volumes of liquids through microchannels, with transport controlled by mixing, heat, mass transport and particle properties 7 , 8 . This technology offers inherent properties such as producing high surface area to volume ratio to test micro/nano particles for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Comparing microfluidics and ultrasonication as formulation methods for developing hempseed oil nanoemulsions for oral delivery applications

Fathordoobady

Sannikova²,

Guo

et al. 2021

Sci Rep

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Emerging formulation technologies aimed to produce nanoemulsions with improved characteristics, such as stability are attractive endeavors; however, comparisons between competing technologies are lacking. In this study, two formulation techniques that employed ultrasound and microfluidic approaches, respectively, were examined for relative capacity to produce serviceable oil in water nanoemulsions, based on hempseed oil (HSO). The ultrasound method reached > 99.5% entrapment efficiency with nanoemulsions that had an average droplet size (Z-Ave) < 180 nm and polydispersity index (PDI) of 0.15 ± 0.04. Surfactant concentration (% w/v) was found to be a significant factor (p < 0.05) controlling the Z-Ave, PDI and zeta potential of these nanoparticles. On the other hand, the microfluidic approach produced smaller particles compared to ultrasonication, with good stability observed during storage at room temperature. The Z-Ave of < 62.0 nm was achieved for microfluidic nanoemulsions by adjusting the aqueous : organic flow rate ratio and total flow rate at 4:1 and 12 mL/min, respectively. Further analyses including a morphology examination, a simulated gastrointestinal release behavior study, transepithelial transport evaluations and a toxicity test, using a Caco2-cell model, were performed to assess the functionality of the prepared formulations. The results of this study conclude that both approaches of ultrasound and microfluidics have the capability to prepare an HSO-nanoemulsion formulation, with acceptable characteristics and stability for oral delivery applications.

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Section: Introductionmentioning

confidence: 99%

Comparing microfluidics and ultrasonication as formulation methods for developing hempseed oil nanoemulsions for oral delivery applications

Fathordoobady

Sannikova²,

Guo

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Formation of particles is chiefly dependent on factors such as surface tension, energy dissipation, fluid resistance, laminar flow and viscosity. Scalability and cost of production remain a challenge, and damage to the microfluidic channels by solvents or occlusion can halt the entire production process [ 125 , 126 ]. Another major challenge in making microfluidic systems is the development of devices that can operate over long time periods in a reliable and controllable manner.…”

Section: General Strategies To Increase Duration Of Actionmentioning

confidence: 99%

“…These systems are, however, also expected to provide benefits in future patient care and possibly fill the gap between animal studies and clinical trials [ 127 ]. Micro-channel and extrusion systems can be used to encapsulate polypeptide in core/shell structures [ 126 ].…”

Section: General Strategies To Increase Duration Of Actionmentioning

confidence: 99%

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

et al. 2020

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Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties.

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“…In recent decades, polymeric microparticles (MPs) have been widely used as drug delivery systems for the controlled release of small molecules, proteins or peptides [1][2][3][4][5]. The reason of this great diffusion is due to several attractive features such as the use of non-laborious techniques [6], low production costs [7], simplicity in industrial scale-up [8] and possibilities of different ways of administration (oral, ocular, parental, inhalation) [9,10]. Particularly, biodegradable MPs composed of PLGA, a random copolymer of poly(glycolic acid) (PGA) and poly(lactic acid) (PLA), are well-established drug delivery systems for small macromolecules involved in the treatment of several important diseases including cancer [11].…”

Section: Introductionmentioning

confidence: 99%

Tunable Release of Curcumin with an In Silico-Supported Approach from Mixtures of Highly Porous PLGA Microparticles

et al. 2020

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In recent years, drug delivery systems have become some of the main topics within the biomedical field. In this scenario, polymeric microparticles (MPs) are often used as carriers to improve drug stability and drug pharmacokinetics in agreement with this kind of treatment. To avoid a mere and time-consuming empirical approach for the optimization of the pharmacokinetics of an MP-based formulation, here, we propose a simple predictive in silico-supported approach. As an example, in this study, we report the ability to predict and tune the release of curcumin (CUR), used as a model drug, from a designed combination of different poly(d,l-lactide-co-glycolide) (PLGA) MPs kinds. In detail, all CUR–PLGA MPs were synthesized by double emulsion technique and their chemical–physical properties were characterized by Mastersizer and scanning electron microscopy (SEM). Moreover, for all the MPs, CUR encapsulation efficiency and kinetic release were investigated through the UV–vis spectroscopy. This approach, based on the combination of in silico and experimental methods, could be a promising platform in several biomedical applications such as vaccinations, cancer-treatment, diabetes therapy and so on.

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Microfluidic assisted synthesis of PLGA drug delivery systems

Abstract: Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible and biodegradable polymer that recently attracted attention for use as part of drug delivery systems (DDS).

Cited by 109 publications

References 124 publications

Comparing microfluidics and ultrasonication as formulation methods for developing hempseed oil nanoemulsions for oral delivery applications

Comparing microfluidics and ultrasonication as formulation methods for developing hempseed oil nanoemulsions for oral delivery applications

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

Tunable Release of Curcumin with an In Silico-Supported Approach from Mixtures of Highly Porous PLGA Microparticles

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