Microfluidic-based Split-Ring-Resonator Sensor for Real-time and Label-free Biosensing

Jaruwongrungsee, Kata; Waiwijit, Uraiwan; Withayachumnankul, Withawat; Maturos, Thitima; Phokaratkul, D.; Tuantranont, Adisorn; Włodarski, W.; Martucci, Alessandro; Wisitsoraat, Anurat

doi:10.1016/j.proeng.2015.08.595

Cited by 31 publications

(17 citation statements)

References 12 publications

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“…The idea is to fabricate a circuit having a split ring shape that is characterized by a microwave resonance spectrum and an electric field localized in the gap. The equivalent electrical circuit includes the capacitance of the split region that is very sensitive to changes in the dielectric properties of the material surrounding and within the gap, such as those that are related to the transit of a particle/cell [ 195 ]. If a high Q factor is achieved, then high sensitivity can be enabled.…”

Section: On-chip Counting Modulesmentioning

confidence: 99%

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

Chiriaco

Bianco

Nigro

et al. 2018

Sensors

127

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Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high number of disorders and pathologies as they are considered as carriers of information among cells, as well as being responsible for the spreading of diseases. Current methods of analysis of microvesicles and exosomes do not fulfill the requirements for their in-depth investigation and the complete exploitation of their diagnostic and prognostic value. Lab-on-chip methods have the potential and capabilities to bridge this gap and the technology is mature enough to provide all the necessary steps for a completely automated analysis of extracellular vesicles in body fluids. In this paper we provide an overview of the biological role of extracellular vesicles, standard biochemical methods of analysis and their limits, and a survey of lab-on-chip methods that are able to meet the needs of a deeper exploitation of these biological entities to drive their use in common clinical practice.

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Section: On-chip Counting Modulesmentioning

confidence: 99%

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

Chiriaco

Bianco

Nigro

et al. 2018

Sensors

127

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“…Meanwhile, metamaterials that can manipulate electromagnetic waves and induce unique electromagnetic properties have been explored as novel sensing platforms with superior properties including a compact size, real-time detection, high sensitivity, and nondestructive detection owing to their highquality resonance characteristics and prominent sensing abilities within the microwave regime, [12][13][14][15] thereby deriving the development of metamaterial-based sensing systems using the humidity, [16] chemical, [17] and biological compositions, [18,19] temperature, [20,21] and photo-detection sensors. [22] In particular, metamaterial-based gas sensors exhibit predominant sensitivity and a rapid response compared to conventional gas sensors operating with a direct current (DC), causing sensitivity and a response-time limitation.…”

Section: Introductionmentioning

confidence: 99%

Wireless‐Powered VOCs Sensor Based on Energy‐Harvesting Metamaterial

Lee

Park

Kim

et al. 2021

Adv Elect Materials

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Wireless‐powered volatile organic compounds (VOCs) are designed by combining an energy‐harvesting metamaterial (EH‐MM) and ionic thermoplastic polyurethane (i‐TPU) as a wireless sensing platform and VOCs sensing material within the microwave frequency, respectively. Using the multi‐analyte sensing capability of an i‐TPU film, the EH‐MM sensor can distinguish different VOCs such as toluene, hexane, ethanol, and acetone, which cause harmful effects on the human body, by simply obtaining the corresponding output voltage levels without any complicated analysis system. The proposed EH‐MM sensor also shows fast and immediate responses (<1 s), a wide range of VOCs concentrations (5–1000 ppm), and long‐term stability (>1 month) under ambient conditions. Moreover, by harvesting commercially accessible WiFi energy, the proposed sensor does not require any battery but can be operated wirelessly, representing a novel method for designing real‐time and battery‐free sensors with a reliable performance.

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“…In Lee and Yook (2008) they are used for the detection of biotin and streptavidin binding, in Lee et al (2012) for the detection of prostate-specific antigen and in Jaruwongrungsee et al (2015) for the detection of immunoglobulin. Furthermore, observation of DNA hybridization is reported in Lee et al (2010).…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of split-ring resonators for aptamer-based biosensors

Reinecke

Walter

Kobelt

et al. 2018

J. Sens. Sens. Syst.

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Abstract. Split-ring resonators are electrical circuits, which enable highly sensitive readout of split capacity changes via a measurement of the shift in the resonance frequency. Thus, functionalization of the split allows the development of biosensors, where selective molecular binding causes a change in permittivity and therefore a change in split capacity. In this work, we present a novel approach using transmission line theory to describe the dependency between permittivity of the sample and resonance frequency. This theory allows the identification of all relevant parameters of a split-ring resonator and thus a target-oriented optimization process. Hereby all setup optimizations are verified with measurements. Subsequently, the split of a resonator is functionalized with aptamers and the sensor response is investigated. This preliminary experiment shows that introducing the target protein results in a shift in the resonance frequency caused by a permittivity change due to aptamer-mediated protein binding, which allows selective detection of the target protein.

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Microfluidic-based Split-Ring-Resonator Sensor for Real-time and Label-free Biosensing

Cited by 31 publications

References 12 publications

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

Wireless‐Powered VOCs Sensor Based on Energy‐Harvesting Metamaterial

Design and evaluation of split-ring resonators for aptamer-based biosensors

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