Microfluidic fabrication of porous PLGA microspheres without pre-emulsification step

Yeh, Szu-I; Fu, Chao–Ming; Sung, Chun-Yen; Kao, Shao‐Hsuan

doi:10.1007/s10404-023-02656-1

Cited by 3 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alternatively, controlled microporosity can be introduced into the green body of CaPs by means of the processing method ( Galván-Chacón and Habibovic, 2017 ), for example, by using porogens, or by templating and 3D printing ( Wu and Uskoković, 2016 ; Raja et al, 2022 ; Mandić et al, 2023 ). Similarly, using porogens in droplet microfluidic methods can result in microparticles with controlled porosity ( Yeh et al, 2023 )).…”

Section: Resultsmentioning

confidence: 99%

Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform

Alaoui Selsouli,

Rho,

Eischen-Loges

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Calcium phosphate (CaP) biomaterials are amongst the most widely used synthetic bone graft substitutes, owing to their chemical similarities to the mineral part of bone matrix and off-the-shelf availability. However, their ability to regenerate bone in critical-sized bone defects has remained inferior to the gold standard autologous bone. Hence, there is a need for methods that can be employed to efficiently produce CaPs with different properties, enabling the screening and consequent fine-tuning of the properties of CaPs towards effective bone regeneration. To this end, we propose the use of droplet microfluidics for rapid production of a variety of CaP microparticles. Particularly, this study aims to optimize the steps of a droplet microfluidic-based production process, including droplet generation, in-droplet CaP synthesis, purification and sintering, in order to obtain a library of CaP microparticles with fine-tuned properties. The results showed that size-controlled, monodisperse water-in-oil microdroplets containing calcium- and phosphate-rich solutions can be produced using a flow-focusing droplet-generator microfluidic chip. We optimized synthesis protocols based on in-droplet mineralization to obtain a range of CaP microparticles without and with inorganic additives. This was achieved by adjusting synthesis parameters, such as precursor concentration, pH value, and aging time, and applying heat treatment. In addition, our results indicated that the synthesis and fabrication parameters of CaPs in this method can alter the microstructure and the degradation behavior of CaPs. Overall, the results highlight the potential of the droplet microfluidic platform for engineering CaP microparticle biomaterials with fine-tuned properties.

show abstract

Section: Resultsmentioning

confidence: 99%

Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform

Alaoui Selsouli,

Rho,

Eischen-Loges

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…are shown in Tables 5 and 6 . 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168…”

Section: Application Of Microfluidic Technology In Ddssunclassified

Research Strategies for Precise Manipulation of Micro/Nanoparticle Drug Delivery Systems Using Microfluidic Technology: A Review

Liu,

Fu,

et al. 2024

Pharmaceutical Fronts

View full text Add to dashboard Cite

Microfluidic technology facilitates precise control over fluid mixing and interactions between the components, including self-assembly and precipitation. It offers new options for accurately manufacturing particles and holds significant potential in advancing micro/nanoparticle drug delivery systems (DDSs). Various microchannel/microfluidic chips have been explored to construct micro/nanoparticle DDSs. The precise manipulation of particle size, morphology, structure, stiffness, surface characteristics, and elasticity through microfluidic technology relies on specific microchannel geometrical designs and the application of exogenous energy, adhering to the principles of fluid motion. Consequently, this enables reproducible control over critical quality attributes (CQAs), such as particle size and distribution, encapsulation efficiency, drug loading, in vitro and in vivo drug delivery profiles, Zeta potential, and targeting capabilities, for micro/nanoparticle DDSs. In this review, we categorize microfluidic techniques and explore recent research developments in novel microchannel structures spanning the past 5 years (2018–2023) and their applications in micro/nanoparticle DDSs. Additionally, we elucidate the latest manipulation strategies of microfluidic techniques that impact foundational structures related to the CQAs of micro/nanoparticle DDSs. Furthermore, we offer insights into the industrial applications and challenges microfluidic techniques face in the context of novel micro/nanoparticle DDSs.

show abstract

Enhanced mixing performance of electrokinetic flows in a cross-junction microchannel with sawtooth structures

Gong,

Chen,

Yuan

et al. 2024

Chemical Engineering and Processing - Process Intensification

View full text Add to dashboard Cite

Microfluidic fabrication of porous PLGA microspheres without pre-emulsification step

Cited by 3 publications

References 39 publications

Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform

Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform

Research Strategies for Precise Manipulation of Micro/Nanoparticle Drug Delivery Systems Using Microfluidic Technology: A Review

Enhanced mixing performance of electrokinetic flows in a cross-junction microchannel with sawtooth structures

Contact Info

Product

Resources

About