Microfluidic lab-on-chip advances for liquid–liquid extraction process studies

Maurice, Ange; Theisen, Johannes; Gabriel, Jean‐Christophe P.

doi:10.1016/j.cocis.2020.03.001

Cited by 40 publications

(19 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current trend in technology aiming to achieve even more compact systems is leading to the development of micro-scale reactors (lab-on-chip) in the field of radiochemical separation and radiopharmaceutical production, in order to improve performance and minimize chemical and radiological risks [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. In this view, a latest generation device, the membrane-based Liquid–Liquid separator, 10 September ( Figure 1 ), patented and produced by ZAIPUT Flow Technologies company (Cambridge, MA, USA), has been recently used for the radiochemical separation of radioisotopes of nuclear medical interest [ 23 , 29 , 30 , 32 ], for the miniaturization of liquid–liquid extraction processes in an in-flow chemistry regime.…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Micro-Scale Liquid-Liquid In-Flow Extraction of 99mTc from Molybdenum

et al. 2021

View full text Add to dashboard Cite

The trend to achieve even more compact-sized systems is leading to the development of micro-scale reactors (lab-on-chip) in the field of radiochemical separation and radiopharmaceutical production. Technetium-99m extraction from both high and low specific activity molybdenum could be simply performed by MEK-driven solvent extraction if it were not for unpractical automation. The aim of this work is to develop a solvent extraction and separation process of technetium from molybdenum in a micro-scale in-flow chemistry regime with the aid of a capillary loop and a membrane-based separator, respectively. The developed system is able to extract and separate quantitatively and selectively (91.0 ± 1.8% decay corrected) the [99mTc]TcO4Na in about 20 min, by using a ZAIPUT separator device. In conclusion, we demonstrated for the first time in our knowledge the high efficiency of a MEK-based solvent extraction process of 99mTc from a molybdenum-based liquid phased in an in-flow micro-scale regime.

show abstract

Section: Introductionmentioning

confidence: 99%

Highly Efficient Micro-Scale Liquid-Liquid In-Flow Extraction of 99mTc from Molybdenum

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This is a road blocking issue as one cannot spend years of R&D to develop a new process for each batch. To solve this bottleneck and enable a fast processing development, computer controlled and automatized microfluidics platforms integrated with characterization methods (infrared [261,262], X-ray fluorescence [14], ICP [263]) have been developed. A review of the state of the art on that front was recently published by [14].…”

Section: Rare-earth Elementsmentioning

confidence: 99%

“…This allows obtaining various fractions: (i) bare boards; (ii) solder; (iii) ECs sorted in elementally enriched subfractions. The goal is for each fraction, or subfraction, to have the simplest elemental composition possible, making them easier to reuse directly or recycle, and making it now possible to recover valuable metals [12] such as Ti, Ga [13] Ba, Ta, Nb, W, Lanthanides [14,15]. It should be noted that classically recycled metals such as Au, Ag or Cu are not covered in this review as there recovery is already extensively discussed in the literature.…”

Section: Introductionmentioning

confidence: 99%

Dismantling of Printed Circuit Boards Enabling Electronic Components Sorting and Their Subsequent Treatment Open Improved Elemental Sustainability Opportunities

et al. 2021

Self Cite

View full text Add to dashboard Cite

This critical review focuses on advanced recycling strategies to enable or increase recovery of chemical elements present in waste printed circuit boards (WPCBs). Conventional recycling involves manual removal of high value electronic components (ECs), followed by raw crushing of WPCBs, to recover main elements (by weight or value). All other elements remain unrecovered and end up highly diluted in post-processing wastes or ashes. To retrieve these elements, it is necessary to enrich the waste streams, which requires a change of paradigm in WPCB treatment: the disassembly of WPCBs combined with the sorting of ECs. This allows ECs to be separated by composition and to drastically increase chemical element concentration, thus making their recovery economically viable. In this report, we critically review state-of-the-art processes that dismantle and sort ECs, including some unpublished foresight from our laboratory work, which could be implemented in a recycling plant. We then identify research, business opportunities and associated advanced retrieval methods for those elements that can therefore be recovered, such as refractory metals (Ta, Nb, W, Mo), gallium, or lanthanides, or those, such as the platinum group elements, that can be recovered in a more environmentally friendly way than pyrometallurgy. The recovery methods can be directly tuned and adapted to the corresponding stream.

show abstract

“…The IR beam provided by a FTIR spectrometer (Bruker Alpha OEM, Bruker Optics Inc., Germany) transmits through the vessel, and the signal are detected by a Stirling Cycle Cooled detector connected with an amplifier (K508-MCT1000, Infrared Associates, U.S.A). They were initially integrated as an on-line monitoring of microfluidic processes (C. Kokoric et al, 2018;Maurice et al, 2020) and have been reconverted here for the purpose of its extraction reactor.…”

Section: Experimental Apparatusmentioning

confidence: 99%

On-line spectroscopic study of brominated flame retardant extraction in supercritical CO2

et al. 2021

Self Cite

View full text Add to dashboard Cite

Extraction of brominated flame retardants (BFRs) from polymers before disposal or recycling will alleviate negative environmental effects and ensure safe usage of recycled products. Supercritical CO2 is appealing as solvent owing to its green properties but also challenging due to its limited solvation power towards polar molecules. For a more comprehensive evaluation of supercritical extraction potentialities, we (i) developed an on-line analytical technique compatible with both UV-vis and FTIR spectroscopies to enable kinetic and thermodynamic studies; (ii) studied kinetic extraction of three conventional and two novel BFRs. Concentration at saturation were determined by gravimetric method or X-ray fluorescence. When compared to UV-vis, FTIR exhibited a higher applicability to follow BFR extraction's time-dependency binary and ternary systems. Faster stirring speed, higher temperature, and finer particle size were found to accelerate overall extraction kinetics. In 2 binary systems, times required to achieve equilibrium for each BFR were less than 2 hours at 60 °C, 25 MPa and 1000 rpm. In ternary systems with the presence of cosolvent (water) or polymeric matrix, extraction kinetics were found to slow down due to competitive dissolution and molecular diffusion within matrix. Mathematical models derived from irreversible desorption and Fick's diffusion laws were applied to fit observed extraction kinetics of BFRs with absolute average relative deviations lower than 5.7%, enabling us to identify the ratedetermining step. Our high solubilization rate coefficients measurements for BFRs proves that it can compensate for their low solubility if one uses flowing supercritical CO2.

show abstract

Microfluidic lab-on-chip advances for liquid–liquid extraction process studies

Cited by 40 publications

References 73 publications

Highly Efficient Micro-Scale Liquid-Liquid In-Flow Extraction of 99mTc from Molybdenum

Highly Efficient Micro-Scale Liquid-Liquid In-Flow Extraction of 99mTc from Molybdenum

Dismantling of Printed Circuit Boards Enabling Electronic Components Sorting and Their Subsequent Treatment Open Improved Elemental Sustainability Opportunities

On-line spectroscopic study of brominated flame retardant extraction in supercritical CO2

Contact Info

Product

Resources

About