2019
DOI: 10.1093/intbio/zyz008
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Microfluidic platform for studying osteocyte mechanoregulation of breast cancer bone metastasis

Abstract: Bone metastasis is a common, yet serious, complication of breast cancer. Breast cancer cells that extravasate from blood vessels to the bone devastate bone quality by interacting with bone cells and disrupting the bone remodeling balance. Although exercise is often suggested as a cancer intervention strategy and mechanical loading during exercise is known to regulate bone remodeling, its role in preventing bone metastasis remains unknown. We developed a novel in vitro microfluidic tissue model to investigate t… Show more

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Cited by 71 publications
(75 citation statements)
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“…Our results also show that pharmaceutical treatments can have an opposite effect on the Ras V12 cell's behavior, depending if the system is being stretched or not. These insights show the importance of considering a mechanically dynamic environment when designing cancer research studies [50], especially in the very earliest stages of therapy development.…”
Section: Discussionmentioning
confidence: 93%
“…Our results also show that pharmaceutical treatments can have an opposite effect on the Ras V12 cell's behavior, depending if the system is being stretched or not. These insights show the importance of considering a mechanically dynamic environment when designing cancer research studies [50], especially in the very earliest stages of therapy development.…”
Section: Discussionmentioning
confidence: 93%
“…Moreover, the authors proposed that macrophages generated microtracks that enable extravasated tumor cells to maintain high invasiveness. Mei et al incubated metastatic breast cancer cells (MDA‐MB‐231) into a microfluidic lumen containing osteocyte‐like MLO‐Y4 cells and HUVECs to analyze the effect of osteocytes mechanoregulation on breast cancer bone metastasis . With the help of a physiologically relevant oscillatory fluid flow (OFF) for mechanical stimuli of osteocytes, the device was able to induce intracellular calcium responses in osteocytes.…”
Section: Microfluidic Platforms For Engineered Tumor Microenvironmentmentioning
confidence: 99%
“…With the aim of modeling bone metastasis, researchers have made use of microfluidic devices to accurately image and quantify cell migration through endothelial structures toward bone microenvironments 70,71. Sano et al designed a microfluidic device where spheroids (containing ECs, fibroblasts, and mesenchymal stromal cells (MSCs)) were embedded in a fibrin‐collagen I hydrogel bordered by functional blood vessels (verified through cell perfusion experiments) 70.…”
Section: Coculture Effects On Cell Movement Through Hydrogelsmentioning
confidence: 99%
“…Mei et al recently published a similar model of breast to bone metastasis through endothelial vessels formed in a hydrogel blend of collagen I and Matrigel. Using this model, they aimed to study the effects of mechanostimulation of osteocytes on cancer cell extravasation 71. Interestingly, MDA‐MB‐231 breast cancer cell extravasation through HUVEC vessels decreased with MLO‐Y4 osteocyte mechanical stimulation (oscillatory fluid flow).…”
Section: Coculture Effects On Cell Movement Through Hydrogelsmentioning
confidence: 99%
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