Microfluidic “thin chips” for chemical separations

Gáspár, Attila; Salgado, Marisol; Stevens, Schetema; Gomez, Frank A.

doi:10.1002/elps.201000067

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Because of low fabrication cost, low material consumption, good analytical performance, and the speed of analysis microfluidics has currently attracted much attention . Microfluidic systems have been widely recognized as a new emerging technology for the development of micro analytical systems, especially for bioassays , biochemical analysis and biosensors as well as chemical synthesis applications essentially require microfluidics for sample handling, treatment or readout .…”

Section: Discussionmentioning

confidence: 99%

Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine

et al. 2013

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Carcinoma of prostate (CaP) is the second most frequent malignant tumor occurring in men in Europe. Currently there is discussion on a wide range of potential CaP markers.One of them—nonprotein amino acid sarcosine, also known as N-methylglycine was chosen as a challenge for the development of microfluidic system with isolation by modified paramagnetic microparticles. Therefore, the aim of this study was to design a low-cost, simple, and rapid microfluidic system based on sarcosine isolation with modified paramagnetic microparticles and subsequent analysis on the ion exchange LC. We modified Dowex microparticles with Fe2O3 nanoparticles. Our paramagnetic microparticles were able to establish the binding with sarcosine. Moreover, we designed microfluidic device for sarcosine determination. Analysis of samples was carried out with LOD of1 M of a sarcosine that is sufficient because it is similar to concentrations of a sarcosine observed in the CaP patients.Carcinoma of prostate (CaP) is the second most frequent malignant tumor occurring in men in Europe. Currently there is discussion on a wide range of potential CaP markers.One of them—nonprotein amino acid sarcosine, also known as N-methylglycine was chosen as a challenge for the development of microfluidic system with isolation by modified paramagnetic microparticles. Therefore, the aim of this study was to design a low-cost, simple, and rapid microfluidic system based on sarcosine isolation with modified paramagnetic microparticles and subsequent analysis on the ion exchange LC. We modified Dowex microparticles with Fe2O3 nanoparticles. Our paramagnetic microparticles were able to establish the binding with sarcosine. Moreover, we designed microfluidic device for sarcosine determination. Analysis of samples was carried out with LOD of1 M of a sarcosine that is sufficient because it is similar to concentrations of a sarcosine observed in the CaP patients.

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Section: Discussionmentioning

confidence: 99%

Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine

et al. 2013

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Fast Fabrication Process of Microfluidic Devices Based on Cyclic Olefin Copolymer

Azouz

Murphy

Karazi

et al. 2014

Materials and Manufacturing Processes

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A new low-cost process for fast fabrication of multilayer microfluidic devices using cyclic olefin copolymer film materials is presented. This novel process consists of the fabrication of microfluidic features by xurography, followed by multilayer lamination via cyclohexane vapor exposure. Exposure time to this solvent and compression time were optimized for bond tensile strength. A three-layer microfluidic chip capable of withstanding back pressures up to 23 MPa was fabricated in less than an hour. The suitability of this fast prototyping method for fabrication of functional UV-transparent microfluidic devices was demonstrated by development and testing of a microfluidic mixer and preparation of a polymer monolithic column within the microfluidic channel.

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Microfluidic “thin chips” for chemical separations

Cited by 2 publications

References 22 publications

Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine

Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine

Fast Fabrication Process of Microfluidic Devices Based on Cyclic Olefin Copolymer

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