Microfluidics and Their Applications to Lab-on-a-Chip

Computer simulation and theory of the diffusion- and flow-induced concentration dispersion in microfluidic devices and HPLC systems based on rectangular microchannels

“…It will be shown that Eqs. (13) and (14) offer an excellent description of the long-term peak characteristics for rectangular microfluidic channels.…”

“…For analytical-chemical purposes, micro-total-analysis systems [3,4] (-TAS, labon-a-chip; for a review see [5][6][7][8][9][10][11]) and other microfluidic systems [12,13] have been introduced as highly promising and extremely useful tools. A common feature of most of these devices is that they essentially consist of microchannels in lyzed by a detector unit.…”

Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications

“…The advent of micro-total-analysis-systems (µTAS) and lab-on-a-chip (LOC) devices will enable the transfer of conventional (bio)chemical analysis techniques, usually carried out by expensive and bulky laboratory equipment, to handheld and comparably inexpensive devices on centimeter length scales [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. As biochemical analysis procedures are naturally carried out in a liquid or physiological environment, the µTAS and LOC devices must be able to perform their tasks when the molecules or cells of interest are dispersed or dissolved in a liquid [ 9 ].…”

Investigation on CO2 laser irradiation inducing glass strip peeling for microchannel formation

“…1 Glass microchannels are normally formed by wet chemical etching, which involves multiple steps such as photomask manufacturing, photolithography, and hydrofluoric acid etching. 2 It is noted that microfluidic channels are generally designed according to the particular requirements of each application, it is frequently necessary to modify the channel design in order to optimize the performance of a microfluidic device. This demand drives to develop rapid prototyping techniques of versatile microfluidics.…”

“…[3][4][5] Laser technique is thus considered a faster alternative to conventional techniques such as wet chemical etching with photomask, lithography, electron beam writing, or photo-patterning in terms of rapid prototyping. 2,6 In fact, great progress has been made in fabrication of glass microchannels using lasers in the past decades. One common method is the use of laser ablation to remove material for microchannel fabrication.…”