Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices

Abstract

Zwitterionic hydrogels exhibit eminent nonfouling and hemocompatibility. Several key challenges hinder their application as coating materials for blood-contacting biomedical devices, including weak mechanical strength and low adhesion to the substrate. Here, we report a poly(carboxybetaine) microgel reinforced poly(sulfobetaine) (pCBM/pSB) pure zwitterionic hydrogel with excellent mechanical robustness and anti-swelling properties. The pCBM/pSB hydrogel coating was bonded to the PVC substrate via the entanglement network between the pSB and PVC chain. Moreover, the pCBM/pSB hydrogel coating can maintain favorable stability even after 21 d PBS shearing, 0.5 h strong water flushing, 1000 underwater bends, and 100 sandpaper abrasions. Notably, the pCBM/pSB hydrogel coated PVC tubing can not only mitigate the foreign body response but also prevent thrombus formation ex vivo in rats and rabbits blood circulation without anticoagulants. This work provides new insights to guide the design of pure zwitterionic hydrogel coatings for biomedical devices.

Multifunctional Oxidized Succinoglycan/Poly(N-isopropylacrylamide-co-acrylamide) Hydrogels for Drug Delivery

“…Hydrogel, a three-dimensional network structure cross-linked with polymer chains, has a porous form and super absorbency, depending on the polymer properties [ 1 ]. Stimulus-responsive hydrogels that can change their volume, shape, and swelling behavior in response to external physical or chemical stimuli are advanced biotechnology materials that can be used in various applications, including tissue engineering and biomedical and drug delivery systems [ 2 , 3 ]. Each of the environmental stimulus responsivity can be classified into pH, temperature, light, redox reaction, chemicals, electric/magnetic fields, etc.…”

Heparin-Network-Mediated Long-lasting Coatings on Intravascular Catheters for Adaptive Antithrombosis and Antibacterial Infection

“…To further demonstrate the delay clotting of HS/DAC coated catheters, an ex-vivo circuit model experiment was carried out, and the catheter with or without coating were implanted in rabbits via an arteriovenous shunt model (Supplementary Fig. 11a) 41 . After experiments, the image of HS/DAC coated catheter exhibited a noticeable reduction in both thrombi and occlusion formation in comparison with bare catheter (Supplementary Fig.…”

Multi-material 3D Printing of Mechanochromic Double Network Hydrogels for On-Demand Patterning

“…Compared with the PCL and PDMS, hydrogels are composed of a large amount of water and have low modulus and large stretchability. They have shown great potential in the biomedical device, − flexible electronics, − soft machines, − and so forth. For instance, the hydraulic hydrogel robot shows excellent optical and sonic camouflage ability in water .…”