are partly a consequence of the heterogeneities of the Earth's crust, in most cases requiring a case-by-case study of granitoid genesis. In other instances, however, uncertainties are a consequence of an insufficient integration of geochemical information with other geological data (field, petrographic, geophysical, etc.), either by scarcity or ambiguousness.We present here the case of the Los Pedroches batholith (LPB), one of the largest Variscan batholiths in Spain, as an example in which a number of the usual uncertainties in granite genesis can be overcome by a careful integration of geochemical and isotopic data with field and petrographic evidence.There are several reasons making the LPB of particular interest. The geological setting is very well constrained, as there is both compelling evidence and a wide consensus on its intrusion age, its emplacement style, and its main subdivision in two plutonic suites (Larrea et al., 2004). Also, the LPB is very suitable for a mineralogical and geochemical study, as all of the LPB units contain very fresh rocks. In addition, the LPB rocks are remarkably homogeneous at a large scale, particularly in the case of the granodioritic rocks (LPG). For these reasons, we consider the LPB as a good target to build up a model, which could be of major interest, not only at a regional scale, but also with regard to the general role of microgranular enclaves as indicators of magma genesis (Received May 15, 2007; Accepted October 6, 2007) To evaluate the origin and significance of microgranular enclaves hosted by granites, we present new data on two granitoid series belonging to the Los Pedroches Batholith (LPB), SW Iberian Massif, Spain. The two series in the LPB show a distinct contrast in terms of field, petrographic, mineralogical and geochemical data. This contrast also extends to the enclaves, differing in abundance and other features in each of the series considered. Isotopic measurements, however, including 87 Sr/ 86 Sr, ε Nd and δ 18 O data, show no significant, inter-or intra-series contrast throughout the LPB. These data lend additional support to an origin of all the granitoid rocks in the LPB from a single, isotopically homogeneous, lower crustal source. We also suggest that differences between microgranular enclaves in the two LPB granitoid series cannot be related to a different degree of participation of mafic rocks in the genesis of the respective groups: in both cases, microgranular enclaves are better interpreted as autoliths.