Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants

Abstract

The effect of depositing a collagen (CG)-poly-ε-caprolactone (PCL) nanofiber mesh (NFM) at the microgrooves of titanium (Ti) on the mechanical stability and osseointegration of the implant with bone was investigated using a rabbit model. Three groups of Ti samples were produced: control Ti samples where there were no microgrooves or CG-PCL NFM, groove Ti samples where microgrooves were machined on the circumference of Ti, and groove-NFM Ti samples where CG-PCL NFM was deposited on the machined microgrooves. Each group of Ti samples was implanted in the rabbit femurs for eight weeks. The mechanical stability of the Ti/bone samples were quantified by shear strength from a pullout tension test. Implant osseointegration was evaluated by a histomorphometric analysis of the percentage of bone and connective tissue contact with the implant surface. The bone density around the Ti was measured by micro–computed tomography (μCT) analysis. This study found that the shear strength of groove-NFM Ti/bone samples was significantly higher compared to control and groove Ti/bone samples (p < 0.05) and NFM coating influenced the bone density around Ti samples. In vivo histomorphometric analyses show that bone growth into the Ti surface increased by filling the microgrooves with CG-PCL NFM. The study concludes that a microgroove assisted CG-PCL NFM coating may benefit orthopedic implants.

Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice

“…Bone mineral density measurements were also performed on the mice after calibration by a standard bone density phantom (QRM-Micro-CT-HA, Möhrendorf, Germany) [ 48 ]. The TBD (including neither the region above the cervical spine nor below the caudal vertebra) and region-specific bone mineral density, including SBD (the region between the cervical spine and caudal vertebra) and FBD were also determined.…”

Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy

“…The site of implantation into the femur of rabbits was determined considering the size of the test specimen and the reactivity between the bone and the implant. The rabbit implantation test was conducted with the implantation location referred to in the literature [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Figure 7 shows the changes in maximum pullout load after rabbit implantation as a function of implantation period.…”

Laser-Induced Microgrooves Improve the Mechanical Responses of Cemented Implant Systems

“…In previous research, we etched microgrooves in metal implants using a precision diamond sawing machine [10]. Our preliminary studies showed that microgrooving cementless titanium (Ti) implants significantly improve biocompatibility, mechanical stability, and osseointegration of the device [11,12]. Laser-induced micro-and nanotexturing that increase the surface area and roughness may further enhance the stability of press-fit implants by increasing friction [13].…”