Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207

Niu, Siwen; Zhou, Tingting; Xie, Conghua; Zhang, Gaiyun; Yang, Xian‐Wen

doi:10.3390/md15070230

Cited by 25 publications

(16 citation statements)

References 35 publications

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“…The in vitro antiproliferative assay was performed using MTT method according to the previously reported protocol [19]. Five different cancer cell lines (BIU-87, Bel-7402, ECA-109, Hela-S3, and PANC-1) were seeded into 96-well cell culture plates.…”

Section: Methodsmentioning

confidence: 99%

Penigrisacids A–D, Four New Sesquiterpenes from the Deep-Sea-Derived Penicillium griseofulvum

et al. 2019

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Four new (penigrisacids A–D, 1–4) and one known (5) carotane sesquiterpenoids were isolated from the deep-sea-derived fungus Penicillium griseofulvum, along with four known compounds (6–9). The planar structures and relative configurations of the new compounds were determined by extensive analysis of the NMR and HRESIMS data. The absolute configurations were established by comparison of the experimental and calculated ECD (electronic circular dichroism) spectra or OR (optical rotation) value. Compound 9 exhibited potent anti-food allergic activity with IC50 value of 28.7 μM, while 4 showed weak cytotoxicity against ECA-109 tumor cells (IC50 = 28.7 μM).

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Section: Methodsmentioning

confidence: 99%

Penigrisacids A–D, Four New Sesquiterpenes from the Deep-Sea-Derived Penicillium griseofulvum

et al. 2019

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“…A 2,3-fused pyrrole alkaloid, microindolinone A ( 128 ), was isolated from the actinomycete Microbacterium sp. MCCC 1A12207 from the deep sea in 2017 [ 128 ]. This tetrahydroindole represents one of two known saturated indoles of natural origin [ 129 ].…”

Section: Non-halogenated Marine Pyrrole Alkaloidsmentioning

confidence: 99%

Marine Pyrrole Alkaloids

2021

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Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment. This review highlights the important class of marine pyrrole alkaloids, well-known for their diverse biological activities. A broad overview of the marine pyrrole alkaloids with a focus on their isolation, biological activities, chemical synthesis, and derivatization covering the decade from 2010 to 2020 is provided. With relevant structural subclasses categorized, this review shall provide a clear and timely synopsis of this area.

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“…that possesses an unusual methylation pattern on the pyrazinone ring [172], a novel indole microindolinone A from Microbacterium sp. [173], new dimeric indole derivatives with acetylcholinesterase (AchE) inhibitory activity from Rubrobacter radiotolerans [174] and a structurally new amycofuran bearing a rhamnose sugar from Amycolatopsis sp. [175].…”

Section: Actinomycetes As Sources Of Antibioticsmentioning

confidence: 99%

Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products

2019

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Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this review, we aim to summarize the present knowledge on the isolation, diversity, distribution and natural product discovery of marine rare actinomycetes reported from mid-2013 to 2017. A total of 97 new species, representing 9 novel genera and belonging to 27 families of marine rare actinomycetes have been reported, with the highest numbers of novel isolates from the families Pseudonocardiaceae, Demequinaceae, Micromonosporaceae and Nocardioidaceae. Additionally, this study reviewed 167 new bioactive compounds produced by 58 different rare actinomycete species representing 24 genera. Most of the compounds produced by the marine rare actinomycetes present antibacterial, antifungal, antiparasitic, anticancer or antimalarial activities. The highest numbers of natural products were derived from the genera Nocardiopsis, Micromonospora, Salinispora and Pseudonocardia. Members of the genus Micromonospora were revealed to be the richest source of chemically diverse and unique bioactive natural products.

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Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207

Cited by 25 publications

References 35 publications

Penigrisacids A–D, Four New Sesquiterpenes from the Deep-Sea-Derived Penicillium griseofulvum

Penigrisacids A–D, Four New Sesquiterpenes from the Deep-Sea-Derived Penicillium griseofulvum

Marine Pyrrole Alkaloids

Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products

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