Microinvasive carcinoma of the breast: can it be diagnosed reliably and is it clinically significant?

Hoda,; Prasad, Vinay; Moore, Paul S.; Giri,

doi:10.1046/j.1365-2559.1999.0820a.x

Cited by 18 publications

(7 citation statements)

References 5 publications

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“…There are similarities and differences between this case and that of Hoda et al 1 . The criteria for microinvasive carcinoma have been previously summarized 2–4 .…”

supporting

confidence: 61%

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Microinvasive lobular carcinoma of the breast

2000

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“…There are similarities and differences between this case and that of Hoda et al 1 . The criteria for microinvasive carcinoma have been previously summarized 2–4 .…”

supporting

confidence: 61%

“…Sir : Hoda et al 1 . recently described a case of lobular carcinoma in‐situ (LCIS) with multiple foci of microinvasive carcinoma as defined by each invasive element not exceeding 1 mm in extent.…”

mentioning

confidence: 99%

Microinvasive lobular carcinoma of the breast

2000

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“…The determination of the invasion foci of mammary tumors enables the prediction of biological behavior. Invasion foci might be associated with metastasis and unfavourable prognosis compared with in situ carcinomas (34).…”

Section: Malignant Transformation Of Bmtsmentioning

confidence: 99%

Consensus regarding the diagnosis, prognosis and treatment of canine mammary tumors: benign mixed tumors, carcinomas in mixed tumors and carcinosarcomas

Cassali¹,

Damasceno²,

Bertagnolli³

et al. 2017

Braz. J. Vet. Pathol.

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Mammary neoplasms are the most frequent tumors in female dogs. Of these neoplasms, benign mixed tumors (BMTs) and carcinomas in mixed tumors (CMTs) represent a large proportion of small animal oncology diagnoses. Together with carcinosarcomas (CSs), these three neoplastic entities are characterized by the proliferation of benign or malignant epithelial, myoepithelial, and mesenchymal cells, depending on their histological types. This histological heterogeneity, in addition to their molecular heterogeneity, confers these tumors with distinct biological behavior, which results in the need for different clinical and therapeutic approaches. The present consensual document elucidates the oncological issues related to the diagnosis, prognosis, and treatment of BMTs, CMTs, and CSs of the canine mammary gland.

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“…Microinvasion is detected with the presence of cytologically malignant cells outside the confines of the basement membrane and myoepithelium [5]. Histological evaluation of minuscule foci of microinvasion is often difficult for the pathologist, because a variety of in situ patterns and artefacts could be misinterpreted as stromal invasion [6-9].…”

Section: Introductionmentioning

confidence: 99%

Expression and role of fibroblast activation protein-alpha in microinvasive breast carcinoma

Hua

Huang

et al. 2011

Diagn Pathol

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BackgroundDiagnosis of ductal carcinoma in situ (DCIS) in breast cancer cases is challenging for pathologist due to a variety of in situ patterns and artefacts, which could be misinterpreted as stromal invasion. Microinvasion is detected by the presence of cytologically malignant cells outside the confines of the basement membrane and myoepithelium. When malignant cells invade the stroma, there is tissue remodeling induced by perturbed stromal-epithelial interactions. Carcinoma-associated fibroblasts (CAFs) are main cells in the microenvironment of the remodeled tumor-host interface. They are characterized by the expression of the specific fibroblast activation protein-alpha (FAP-α), and differ from that of normal fibroblasts exhibiting an immunophenotype of CD34. We hypothesized that staining for FAP-α may be helpful in determining whether DCIS has microinvasion.Methods349 excised breast specimens were immunostained for smooth muscle actin SMA, CD34, FAP-α, and Calponin. Study material was divided into 5 groups: group 1: normal mammary tissues of healthy women after plastic surgery; group 2: usual ductal hyperplasia (UDH); group 3: DCIS without microinvasion on H & E stain; group 4: DCIS with microinvasion on H & E stain (DCIS-MI), and group 5: invasive ductal carcinoma (IDC). A comparative evaluation of the four immunostains was conducted.ResultsOur results demonstrated that using FAP-α and Calponin adjunctively improved the sensitivity of pathological diagnosis of DCIS-MI by 11.29%, whereas the adjunctive use of FAP-α and Calponin improved the sensitivity of pathological diagnosis of DCIS by 13.6%.ConclusionsThis study provides the first evidence that immunostaining with FAP-α and Calponin can serve as a novel marker for pathologically diagnosing whether DCIS has microinvasion.

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Microinvasive carcinoma of the breast: can it be diagnosed reliably and is it clinically significant?

Cited by 18 publications

References 5 publications

Microinvasive lobular carcinoma of the breast

Microinvasive lobular carcinoma of the breast

Consensus regarding the diagnosis, prognosis and treatment of canine mammary tumors: benign mixed tumors, carcinomas in mixed tumors and carcinosarcomas

Expression and role of fibroblast activation protein-alpha in microinvasive breast carcinoma

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