Biological microlasers have advanced rapidly in recent years, demonstrating their immense potential to use lasing emission as a sensing signal for monitoring molecular interactions. [1-6] Such lasers are known for their distinct advantages in terms of signal amplification, narrow linewidth, and strong intensity, which lead to unprecedented detection sensitivity of tiny changes in biological systems. [7-11] Most biolasers were realized through the introduction of fluorescent biomolecules (gain) into millimeter-sized resonators, resulting in difficulties for further applications. As such, whispering-gallery-mode (WGM) microlasers have come into play for their high Q factor, low mode volume, and miniaturized size. [12-15] A plethora of biocompatible materials have been used to form microlasers in recent years, including proteins, poly(lactic acid), starch, lipids, liquid crystals, cellulose, and polymers. [13,16-26] To move a step forward, it is essential to realize microlasers with the versatility to design, control, and functionalize different biostructures and molecules within the cavity. Hydrogels, one of the most popular biomaterials, have received tremendous attention for its high versatility among biocompatible materials over decades. [27,28] Endowed with unique 3D network structures and a porous interface, hydrogels enjoy priority in a wide range of applications in drug delivery, therapeutics, tissue engineering, and biosensing devices. [29-31] Hydrogels can be used to encapsulate