Micromanipulation System for Isolating a Single Cryptosporidium Oocyst

Penny, Hamish; Hayman, David T. S.; Avci, Ebubekir

doi:10.3390/mi11010003

Cited by 7 publications

(4 citation statements)

References 41 publications

(48 reference statements)

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“…Such methods typically have a larger range of motion (greater than the diameter of manipulated object). They can move an object between environments, for example, liquid/air, ambience/magnetic field, or electrostatic field area [13]. Primary contact micromanipulation devices are microelectromechanical system (MEMS) microgrippers, micro hands, microrobots, micropipettes.…”

Section: Fig 1 a Schematic Representation Of The Micromanipulation Task In Respect Of Various Parametersmentioning

confidence: 99%

Robotic micromanipulation: a) actuators and their application

Bučinskas¹,

Subačiūtė-Žemaitienė²,

Dzedzickis³

et al. 2021

Robot. syst., appl.

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Development of biotechnology and technologies related to small size object position and placement in working area, ensuring desired orientation and fitting during movement into prescribed positions. Paper provides an effort to classify and provide a sorted list of applications in the variety of existing robotic systems to manipulate the object of micrometric size. Extensive development of robotic systems fosters intensive request of accurate and fast drives for robots and manipulators. Paper overviews and specifies a broad spectrum of micrometric scale drives, operating under certain physical effects. These drives are analyzed according to their physical domain, movement mode, stroke or angle range, generated force, speed of movement and other essential drive parameters. The paper concludes a high potential of drives development and points direction to future their application possibilities in microrobotics.

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Section: Fig 1 a Schematic Representation Of The Micromanipulation Task In Respect Of Various Parametersmentioning

confidence: 99%

Robotic micromanipulation: a) actuators and their application

Bučinskas¹,

Subačiūtė-Žemaitienė²,

Dzedzickis³

et al. 2021

Robot. syst., appl.

View full text Add to dashboard Cite

show abstract

“…Depending on the specific context of applications and their corresponding precision requirements, the tethered [ 8 , 9 , 10 ] or untethered [ 11 , 12 , 13 ] mode of micromanipulation may be employed. With growing needs towards dexterous micromanipulation, the control of contact forces is one of the major issues to tackle.…”

Section: Introductionmentioning

confidence: 99%

A Two-Axis Piezoresistive Force Sensing Tool for Microgripping

Tiwari

Billot

Clevy

et al. 2021

Sensors

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Force sensing has always been an important necessity in making decisions for manipulation. It becomes more appealing in the micro-scale context, especially where the surface forces become predominant. In addition, the deformations happening at the very local level are often coupled, and therefore providing multi-axis force sensing capabilities to microgripper becomes an important necessity. The manufacturing of a multi-axis instrumented microgripper comprises several levels of complexity, especially when it comes to the single wafer fabrication of a sensing and actuation mechanism. To address these requirements, in this work, an instrumented two-axis force sensing tool is proposed, which can then be integrated with the appropriate actuators for microgripping. Indeed, based on the task, the gripper design and shape requirements may differ. To cover wide needs, a versatile manufacturing strategy comprising of the separate fabrication of the passive and sensing parts was especially investigated. At the microscale, signal processing brings additional challenges, especially when we are dealing with multi-axis sensing. Therefore, a proper device, with efficient and appropriate systems and signal processing integration, is highly important. To keep these requirements in consideration, a dedicated clean-room based micro-fabrication of the devices and corresponding electronics to effectively process the signals are presented in this work. The fabricated sensing part can be assembled with wide varieties of passive parts to have different sensing tools as well as grippers. This force sensing tool is based upon the piezoresistive principle, and is experimentally demonstrated with a sensing capability up to 9 mN along the two axes with a resolution of 20 μN. The experimental results validate the measurement error within 1%. This work explains the system design, its working principle, FEM analysis, its fabrication and assembly, followed by the experimental validation of its performance. Moreover, the use of the proposed sensing tool for an instrumented gripper was also discussed and demonstrated with a micrograsping and release task.

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“…To overcome these problems of transplantation, in recent decades, tissue engineering-the development of complex tissues and organs-has grown as a new scientific field. For example, bioprinting [1][2][3], cell sheet engineering [4][5][6], and automated robotics approaches on the microscale [7][8][9][10] have been researched to build 2D and 3D structures. Among these methods, the manipulation of microobjects using a robotics system is an appropriate solution for building complex tissues or organs because it can assemble complex structure composed of different materials.…”

Section: Introductionmentioning

confidence: 99%

High-Speed Manipulation of Microobjects Using an Automated Two-Fingered Microhand for 3D Microassembly

et al. 2020

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To assemble microobjects including biological cells quickly and precisely, a fully automated pick-and-place operation is applied. In micromanipulation in liquid, the challenges include strong adhesion forces and high dynamic viscosity. To solve these problems, a reliable manipulation system and special releasing techniques are indispensable. A microhand having dexterous motion is utilized to grasp an object stably, and an automated stage transports the object quickly. To detach the object adhered to one of the end effectors, two releasing methods—local stream and a dynamic releasing—are utilized. A system using vision-based techniques for the recognition of two fingertips and an object, as well automated releasing methods, can increase the manipulation speed to faster than 800 ms/sphere with a 100% success rate (N = 100). To extend this manipulation technique, 2D and 3D assembly that manipulates several objects is attained by compensating the positional error. Finally, we succeed in assembling 80–120 µm of microbeads and spheroids integrated by NIH3T3 cells.

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Micromanipulation System for Isolating a Single Cryptosporidium Oocyst

Cited by 7 publications

References 41 publications

Robotic micromanipulation: a) actuators and their application

Robotic micromanipulation: a) actuators and their application

A Two-Axis Piezoresistive Force Sensing Tool for Microgripping

High-Speed Manipulation of Microobjects Using an Automated Two-Fingered Microhand for 3D Microassembly

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