Micromilling of microbarbs for medical implants

Filiz, Sinan; Xie, Luke; Weiss, Lee E.; Özdoğanlar, O. Burak

doi:10.1016/j.ijmachtools.2007.08.020

Cited by 76 publications

(30 citation statements)

References 15 publications

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“…This isolated response is then used to calculate the FRFs from Eqs. (5) and (6). The amplitude and phase plots of the obtained direct (H AA xx ) and cross (H AA yx ) FRFs measured at point A, as well as the corresponding coherence plots, are given in Fig.…”

Section: Obtaining Spindle Dynamicsmentioning

confidence: 99%

“…Mechanical micromachining is one of the emerging techniques for fabricating three-dimensional (3D) complex micro-scale features on a broad range of materials [1,2], including metals (e.g., [3]) and polymers (e.g., [4,5]). In order to attain high material removal rates while using micro-scale cutting tools (as small as 25 μm in diameter), miniature ultra-high-speed (UHS) spindles that can rotate at speeds above 60,000 rpm 1 are used in mechanical micromachining [1].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dynamics of ultra-high-speed (UHS) spindles used for micromachining

Bediz

Gozen

Korkmaz

et al. 2014

International Journal of Machine Tools and Manufacture

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Section: Obtaining Spindle Dynamicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dynamics of ultra-high-speed (UHS) spindles used for micromachining

Bediz

Gozen

Korkmaz

et al. 2014

International Journal of Machine Tools and Manufacture

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“…A range of biocompatible polymers including, singly or in combination, poly-L-lactic acid (PLA) (24–26), poly-glycolic acid (PGA) (24), poly-lactic-co-glycolic acid (PLGA) (24–26), cyclic-olefin copolymer (COC) (27,28), poly (vinyl pyrrolidone) (PVP) (29), poly (vinyl) alcohol (PVA) (30), carboxymethyl cellulose (CMC) (25,31), and silk (32), as well as sugars including galactose (33), maltose (34,35), and dextrin (33) have been used to fabricate dissolvable MNAs. Many different technologies have been used for fabrication of dissolvable MNAs such as photo-lithography (36) and laser etching (38) to createmolds and injection molding, investment molding, casting, and hot embossing to create the final needle arrays (27,28,36). The bioactive material to be delivered is encapsulated into the dissolvable (matrix) material through the fabrication process; thus, when dissolved, MNAs deliver the cargo in bolus or sustained fashion.…”

Section: Introductionmentioning

confidence: 99%

Dissolvable Microneedle Arrays for Intradermal Delivery of Biologics: Fabrication and Application

et al. 2013

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Purpose Design and evaluate a new micro-machining based approach for fabricating dissolvable microneedle arrays (MNAs) with diverse geometries and from different materials for dry delivery to skin microenvironments. The aims are to describe the new fabrication method, to evaluate geometric and material capability as well as reproducibility of the method, and to demonstrate the effectiveness of fabricated MNAs in delivering bioactive molecules. Methods Precise master molds were created using micromilling. Micromolding was used to create elastomer production molds from master molds. The dissolvable MNAs were then fabricated using the spin-casting method. Fabricated MNAs with different geometries were evaluated for reproducibility. MNAs from different materials were fabricated to show material capability. MNAs with embedded bioactive components were tested for functionality on human and mice skin. Results MNAs with different geometries and from carboxymethyl cellulose, polyvinyl pyrrolidone and maltodextrin were created reproducibly using our method. MNAs successfully pierce the skin, precisely deliver their bioactive cargo to skin and induce specific immunity in mice. Conclusions We demonstrated that the new fabrication approach enables creating dissolvable MNAs with diverse geometries and from different materials reproducibly. We also demonstrated the application of MNAs for precise and specific delivery of biomolecules to skin microenvironments in vitro and in vivo.

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“…As such, mechanical micromanufacturing processes provide capabilities that are complementary to lithographic processes used in microelectromechanical systems fabrication [1,2] in terms of materials, geometries, and dimensions [3]. In particular, micromachining, which uses microscale milling and drilling tools within high precision machining environments, has the potential to become an effective and widespread technique for creating 3D structures and devices [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Supercritical Carbon Dioxide Based Metalworking Fluids in Micromilling

Supekar

Gozen

Bediz

et al. 2013

Journal of Manufacturing Science and Engineering

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This article investigates the feasibility of using supercritical carbon dioxide based metalworking fluids (SCCO2 metalworking fluids (MWFs)) to improve micromachinability of metals. Specifically, sets of channels were fabricated using micromilling on 304 stainless steel and 101 copper under varying machining conditions with and without SCCO2 MWF. Burr formation, average specific cutting energy, surface roughness, and tool wear were analyzed and compared. Compared to dry machining, use of scCOi MWF reduced burr formation in both materials, reduced surface roughness by up to 69% in 304 stainless steel and up to 33% in 101 copper, tool wear by up to 20% in 101 copper, and specific cutting energy by up to 87% in 304 stainless steel and up to 40% in 101 copper. The results demonstrate an improvement in micromachinability of the materials under consideration and motivate future investigations of SCCO2 MWF-assisted micromachining to reveai underlying mechanisms of functionality, as well as to directly compare the performance ofscCO2 MWF with alternative MWFs appropriate for micromachining.

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Micromilling of microbarbs for medical implants

Cited by 76 publications

References 15 publications

Dynamics of ultra-high-speed (UHS) spindles used for micromachining

Dynamics of ultra-high-speed (UHS) spindles used for micromachining

Dissolvable Microneedle Arrays for Intradermal Delivery of Biologics: Fabrication and Application

Feasibility of Supercritical Carbon Dioxide Based Metalworking Fluids in Micromilling

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