Microneedle-assisted transdermal delivery of Zolmitriptan: effect of microneedle geometry, <i>in vitro</i> permeation experiments, scaling analyses and numerical simulations

Uppuluri, Chandra Teja; Devineni, Jyothirmayee; Han, Tao; Nayak, Atul; Nair, Karthik J.; Whiteside, Ben; Das, Diganta Bhusan; Nalluri, Buchi N.

doi:10.1080/03639045.2017.1313862

Cited by 12 publications

(6 citation statements)

References 20 publications

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“…These patches were worn for up to 2 h and did not provide sustained drug release 21 . Previous studies have demonstrated that microneedle patches are painless 30,31 , can be self-administered with minimal training [32][33][34] and are otherwise well tolerated in clinical trials [33][34][35][36] . Building off previous literature, the development of microneedle patches for long-acting contraception requires the formulation of microneedles for slow release of contraceptive hormones and engineering of microneedles that can be embedded in the skin after simple and rapid separation from the patch backing.…”

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confidence: 99%

Rapidly separable microneedle patch for the sustained release of a contraceptive

et al. 2019

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Nature Research wishes to improve the reproducibility of the work that we publish. This form provides structure for consistency and transparency in reporting. For further information on Nature Research policies, see Authors & Referees and the Editorial Policy Checklist. Statistical parameters When statistical analyses are reported, confirm that the following items are present in the relevant location (e.g. figure legend, table legend, main text, or Methods section). n/a Confirmed The exact sample size (n) for each experimental group/condition, given as a discrete number and unit of measurement An indication of whether measurements were taken from distinct samples or whether the same sample was measured repeatedly The statistical test(s) used AND whether they are one-or two-sided Only common tests should be described solely by name; describe more complex techniques in the Methods section.

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confidence: 99%

Rapidly separable microneedle patch for the sustained release of a contraceptive

et al. 2019

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“…[13] Uppuluri et al applied AdminPatch of different lengths (0.6, 0.9, 1.2, 1.5 mm) on pig ears where the average FPL (N = 3) only fluctuated between 30%, 33.58%, 33.4%, and 31.89%, respectively. [175] Increasing the MN height can also induce erythema, edema, hyper pigmentation, additional fabrication costs, buckling failure, or skin scars. [10] Moreover, MN length has the strongest effect on pain with a threefold increase in MN length, producing a sevenfold increase in the pain.…”

Section: Enhancing Microneedle Penetrationmentioning

confidence: 99%

Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

Ebrahiminejad

Prewett

Davies

et al. 2022

Adv Materials Inter

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DDS can also be in the form of rapid parenteral intravenous, intramuscular, or subcutaneous delivery, which is suitable for emergency situations and mostly accompanied with pain, and hence not preferred by patients. [2,3] Inhalation drug delivery is a painless DDS method received through the lungs that is mainly used for respiratory diseases with the risk of overdosing upon self-administrations. [4] Another method of drug delivery is transdermal drug delivery through skin layers via application of creams, hypodermic needles, ultrasound, electroporation, iontophoresis, or use of microneedles (MNs). [4][5][6] In therapeutic monitoring, early stage diagnostics, efficiency of biological samples, timely analysis, non-invasiveness, and potential for self-administration are all highly desirable. [7] Point-of-care (POC) medical tests using MNs have the potential to provide rapid, minimally invasive, and real time diagnostics, [7] sampling either capillary blood or interstitial fluid (ISF) in competition with venous blood, breath, stool, and sputum. ISF has been shown to contain 83% of serum proteins, only 50% of which are found in serum, indicting the significance of ISF biomarkers for monitoring and diagnostics. [8,9] Therefore, ongoing pathophysiological events such as chronic conditions can be rapidly and painlessly detected using POC MN diagnostic systems enabling collection of ISF samples with unique biomarkers using MN systems. [10] Single MNs can be used as a painless alternative to steel hypodermic needles but they are more likely to be used as arrays of multiple MNs incorporated into diagnostic or therapeutic patches. [11] Their painless, non-invasive, and selfadministrative capabilities have received increasing attention in recent years. [12] Conventional hypodermic needles can induce pain, are semi-invasive, create hazardous wastes, and require trained medical staff for administration. Instead, minimally invasive MNs can be administrated without discomfort to the patient by bypassing the stratum corneum (SC) barrier of skin, [12][13][14] while avoiding contact with nerve system and blood vessels. It can be self-administrated and create less waste in comparison to the traditional hypodermic needles. [15][16][17] MNs are potentially capable of delivering ionic, hydrophilic, and large molecular weight drugs more effectively than passive diffusion using needle-free patches or topical creams. [18,19] Thus, MNs are an attractive candidate for delivery of drugs including insulins, growth hormones, proteins, siRNA, immunobiological,

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“…Besides, the results showed that the longer the microneedle length, the higher the insulin concentration in mice [ 114 ]. Similarly, Chandra et al observed the relationship between the amount of drug delivered and the thickness and surface area of the skin, which indicated the role of the geometric parameters of the microneedles [ 115 ].…”

Section: Pitfallsmentioning

confidence: 99%

Advances of Microneedles in Biomedical Applications

Xuan

et al. 2021

Molecules

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A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

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Microneedle-assisted transdermal delivery of Zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations

Cited by 12 publications

References 20 publications

Rapidly separable microneedle patch for the sustained release of a contraceptive

Rapidly separable microneedle patch for the sustained release of a contraceptive

Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

Advances of Microneedles in Biomedical Applications

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