Microneedle-Mediated Biomimetic Cyclodextrin Metal Organic Frameworks for Active Targeting and Treatment of Hypertrophic Scars

Wu, Tong; Hou, Xiaolin; Li, Jiaqi; Ruan, Hang; Pei, Lixia; Guo, Teng; Wang, Zhi; Ci, Tianyuan; Ruan, Shuyao; He, Yuanzhi; He, Zhiyao

doi:10.1021/acsnano.1c07829

Cited by 82 publications

(46 citation statements)

References 50 publications

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“…For example, scars can develop when the translocation of β -catenin in fibroblasts is enhanced by Wnt, thereby leading to proliferation, migration, and transition of fibroblasts into myofibroblasts, as well as deposition of type I collagen [ 62 ]. Reduced expression of collagen I and III was observed in a biomimetic nanodrug delivery system with increased efficacy on hypertrophic scars by regulating Wnt/ β -catenin and JAK2/STAT3 pathways [ 63 ]. Interestingly, Sun et al recently discovered that activation of sonic hedgehog can eliminate the negative effect brought by long-term Wnt signaling [ 64 ].…”

Section: Regulation Of Fibroblasts In Wound Healing and Scar Formationmentioning

confidence: 99%

Fibroblasts in Scar Formation: Biology and Clinical Translation

Qian

Shan

Gong

et al. 2022

Oxidative Medicine and Cellular Longevity

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Scarring, which develops due to fibroblast activation and excessive extracellular matrix deposition, can cause physical, psychological, and cosmetic problems. Fibroblasts are the main type of connective tissue cells and play important roles in wound healing. However, the underlying mechanisms of fibroblast in reaching scarless wound healing require more exploration. Herein, we systematically reviewed how fibroblasts behave in response to skin injuries, as well as their functions in regeneration and scar formation. Several biocompatible materials, including hydrogels and nanoparticles, were also suggested. Moreover, factors that concern transformation from fibroblasts into cancer-associated fibroblasts are mentioned due to a tight association between scar formation and primary skin cancers. These findings will help us better understand skin fibrotic pathogenesis, as well as provide potential targets for scarless wound healing therapies.

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Section: Regulation Of Fibroblasts In Wound Healing and Scar Formationmentioning

confidence: 99%

Fibroblasts in Scar Formation: Biology and Clinical Translation

Qian

Shan

Gong

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…The imaging functions can also be used to monitor and investigate the pharmacokinetics of drugs. In addition, the compositions of nanocarriers or MNs, in addition to drugs, can have intrinsic therapeutic functions 38 . All of these can contribute to improving treatment outcomes.…”

Section: Design Principles Of Nanocarrier- and Mn-based Delivery Syst...mentioning

confidence: 99%

“…In a recent study, Wu et al developed dissolvable Bletilla striata polysaccharide (BSP) MNs to deliver hypertrophic scar fibroblast (HSF) membrane-coated nanocarriers for the treatment of hypertrophic scars 38 . The HSF membrane of nanocarriers generated homologous targeting effects to dermal fibroblasts and improved the therapeutic effects.…”

Section: Mn-based Drug Delivery Strategiesmentioning

confidence: 99%

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Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Qu¹,

Geng²,

Liu³

et al. 2022

Theranostics

103

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Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a global burden and affecting the world economy. Skin diseases severely impact the patients' quality of life and have influenced their physical and mental state. Treatment of these skin disorders with conventional methods shows a lack of therapeutic efficacy, long treatment duration, recurrence of the condition, and systemic side effects due to improper drug delivery. However, these pitfalls can be overcome with the applications of advanced nanocarrier- and microneedle (MN)-based transdermal drug delivery strategies that provide efficient site-specific drug delivery at the target site. These advanced transdermal drug delivery strategies can be more effective than other drug administration routes by avoiding first-pass metabolism, enhancing the drug concentration in local skin lesions, and reducing systemic toxicity. Compared with traditional transdermal delivery methods, nanocarrier- or MN-based drug delivery systems are painless, noninvasive, or minimum-invasive and require no expensive equipment. More importantly, they can introduce more advanced functions, including increased skin penetration efficiency, controlled drug release rates, enhanced targeting abilities, and theranostic functions. Here, the emergence of versatile advanced transdermal drug delivery systems for the transdermal delivery of various drugs is reviewed, focusing on the design principles, advantages, and considerations of nanocarrier- and MN-based transdermal drug delivery strategies and their applications in treating diverse skin diseases, including psoriasis, dermatitis, melanoma, and other skin diseases. Moreover, the prospects and challenges of advanced transdermal delivery strategies for treating dermatological disorders are summarized.

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“…BSP showed synergistic effects, and the mechanical strength was superior to HA-based MN. This system reduced the expression of collagens I and III in HSs to improve the treatment efficacy of HSs, and MNs prepared in this way had better mechanical strength than HA-based MNs [ 98 ].…”

Section: Polysaccharide Based Drug Delivery For Diseases Therapeuticsmentioning

confidence: 99%

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

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Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources. Compared with synthetic polymers, polysaccharides have the advantages of non-toxicity and biodegradability, ease of modification, biocompatibility, targeting, and antibacterial properties. Currently, polysaccharide-based transdermal drug delivery vehicles, such as hydrogel, film, microneedle (MN), and tissue scaffolds are being developed. The addition of polysaccharides allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile strength, etc. Due to the stratum corneum’s resistance, the transdermal drug delivery system cannot deliver drugs as efficiently as desired. The charge and hydration of polysaccharides allow them to react with the skin and promote drug penetration. In addition, polysaccharide-based nanotechnology enhances drug utilization efficiency. Various diseases are currently treated by polysaccharide-based transdermal drug delivery devices and exhibit promising futures. The most current knowledge on these excellent materials will be thoroughly discussed by reviewing polysaccharide-based transdermal drug delivery strategies.

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Microneedle-Mediated Biomimetic Cyclodextrin Metal Organic Frameworks for Active Targeting and Treatment of Hypertrophic Scars

Cited by 82 publications

References 50 publications

Fibroblasts in Scar Formation: Biology and Clinical Translation

Fibroblasts in Scar Formation: Biology and Clinical Translation

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Polysaccharide-Based Transdermal Drug Delivery

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