Microneedle‐Mediated Transcutaneous Immunization: Potential in Nucleic Acid Vaccination

Wang, Haochen; Xu, Junhua; Xiang, Lin

doi:10.1002/adhm.202300339

Cited by 10 publications

(3 citation statements)

References 160 publications

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“…[58,59] From 2012 to 2022, 26 clinical trials have been conducted worldwide, according to relevant reports, more than 80% of participants preferred the microneedle patches for vaccination compared to traditional methods of drug administration. [60] In addition, electroporation has also been proven to vaccine delivery by increasing the electric field. However few clinical trials have shown the efficacy of physical transdermal delivery device nucleic acid vaccination.…”

Section: Microneedles Based Intelligent Transdermal Devicesmentioning

confidence: 99%

Smart Physical‐Based Transdermal Drug Delivery System:Towards Intelligence and Controlled Release

Zhang,

Pan,

Hou

et al. 2023

Small

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Transdermal drug delivery systems based on physical principles have provided a stable, efficient, and safe strategy for disease therapy. However, the intelligent device with real‐time control and precise drug release is required to enhance treatment efficacy and improve patient compliance. This review summarizes the recent developments, application scenarios, and drug release characteristics of smart transdermal drug delivery systems fabricated with physical principle. Special attention is paid to the progress of intelligent design and concepts in of physical‐based transdermal drug delivery technologies for real‐time monitoring and precise drug release. In addition, facing with the needs of clinical treatment and personalized medicine, the recent progress and trend of physical enhancement are further highlighted for transdermal drug delivery systems in combination with pharmaceutical dosage forms to achieve better transdermal effects and facilitate the development of smart medical devices. Finally, the next generation and future application scenarios of smart physical‐based transdermal drug delivery systems are discussed, a particular focus in vaccine delivery and tumor treatment.

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Section: Microneedles Based Intelligent Transdermal Devicesmentioning

confidence: 99%

Smart Physical‐Based Transdermal Drug Delivery System:Towards Intelligence and Controlled Release

Zhang,

Pan,

Hou

et al. 2023

Small

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“…2B and 2C), verifying the thicknesses that can be penetrated were 508 µm. There is little doubt that the skin is divided into three main structural layers: stratum corneum, epidermis and dermis, while the stratum corneum with about 10-20 µm thick, is the skin's main barrier against drug penetration [42]. According to the above ndings, PLA MNs are adequate to pierce the stratum corneum and promote rapid drug absorption by creating micropore.…”

Section: The Insertion Properties Of Mnsmentioning

confidence: 99%

“…Then, the rat skin was folded and pretreated with PLA MNs. OCT hand-held probe was used to scan the skin of rats pretreated with MNs, and OCT images were collected to observe the insertion of MNs [42]. Then, to observe the healing of the MNs forming micropores, the MNs were removed after 30 s and observed micropores using a handheld microscope (Anmo electronics) and OCT.…”

Section: Rats Skin Insertion Of Mnsmentioning

confidence: 99%

Toward a solid microneedle patch for rapid and enhanced local analgesic action

Liu,

Zhao,

Liang

et al. 2023

Preprint

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Analgesic creams find widespread application as adjuncts for localized anesthesia prior to surgical procedures. Nevertheless, the onset of analgesic action is protracted due to the skin barrier's inherent characteristics, which necessitates prolonged intervals of patient and clinician waiting, consequently impinging upon patient compliance and clinician workflow efficiency. In this work, a biodegradable microneedles (MNs) patch was introduced to enhance the transdermal administration of lidocaine cream to achieve rapid analgesia through a minimally invasive and conveniently accessible modality. The polylactic acid (PLA) MNs were mass-produced using a simple hot-pressing method and served the purpose of creating microchannels across the skin’s surface for rapid absorption of lidocaine cream. Optical and electron microscopes were applied to meticulously scrutinize the morphology of the fabricated MNs, and the comprehensive penetration tests involving dynamometer, Optical Coherence Tomography (OCT) and animal skins demonstrated the robust mechanical strength of PLA MNs for successful transdermal penetration. The behavioral pain sensitivity tests on living rats revealed that the MNs-assisted lidocaine treatment expeditiously accelerated the onset of action and substantially enhanced the efficacy of localized anesthesia. Furthermore, different treatment protocols encompassing the sequence of drug application relative to MNs treatment, MNs dimensions, and the frequency of MNs insertions exhibited noteworthy influence on the resultant local anesthesia efficacy. Together these results demonstrated that the lidocaine cream followed by diverse PLA MNs treatments would be a promising strategy for rapid clinical local anesthesia with wide-ranging applications.

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Local Delivery of Glabridin by Biomolecular Microneedle to Accelerate Infected Wound Healing

Chen,

Hu,

Wang

et al. 2023

Adv Healthcare Materials

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Applying antibacterial polymers and pro‐regenerative small molecules are two individual strategies for accelerating wound healing. However, integrating those two unique approaches into one therapeutic platform that meets clinical requirements is still a challenge. Herein, a series of antibacterial gelatin methacrylate (GelMA)/ε‐polylysine (ε‐PL) composite hydrogels (termed as GP‐n HGs, n = 0, 10, 20 and 30, respectively) were innovatively fabricated by ultraviolet light (UV) crosslinking. The GP‐n HGs were proved to be broad‐spectrum antibacterial and biocompatible. Among those GP‐n HGs, the GP‐20 HG was selectively processed into microneedle following a mold‐casting method. Then, the glabridin was loaded into those needles to produce composite microneedle termed GP‐20@Gla MN. An S. aureus‐infected full‐thickness defect model in rats was created to evaluate the wound‐healing effect of GP‐20@Gla MN. Furthermore, an RNA sequencing assay was performed to explore the possible molecular mechanisms of glabridin in promoting tissue regeneration, and many positive routes have been summarized. This work is of significant novelty in fulfilling complex clinical needs by simultaneously optimizing the advanced microneedles' chemical compositions and physical structures. This work will provide a promising therapeutic platform for treating infected and chronic wounds.This article is protected by copyright. All rights reserved

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Microneedle‐Mediated Transcutaneous Immunization: Potential in Nucleic Acid Vaccination

Cited by 10 publications

References 160 publications

Smart Physical‐Based Transdermal Drug Delivery System:Towards Intelligence and Controlled Release

Smart Physical‐Based Transdermal Drug Delivery System:Towards Intelligence and Controlled Release

Toward a solid microneedle patch for rapid and enhanced local analgesic action

Local Delivery of Glabridin by Biomolecular Microneedle to Accelerate Infected Wound Healing

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