Microneedles: a therapeutic alternative in melasma

Soto, Claudia Marcela Arenas

doi:10.15406/jdc.2018.02.00079

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…This produces small holes known as micro‐conduits, with minimal damage to the epidermis, allowing migration of epithelial and endothelial cells. The procedure has been shown to promote growth factor release and thus stimulate fibroblast proliferation, while also enhancing collagen and elastin production in the papillary layer of the epidermis, inducing beneficial wound healing with a few side‐effects …”

Section: Introductionmentioning

confidence: 99%

Study of efficacy of microneedling and mesoneedling in the treatment of epidermal melasma: A pilot trial

Farshi

Mansouri

2020

J of Cosmetic Dermatology

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Background: Melasma is a difficult to treat pigmentation disorder. However, some successes have been attained by microneedling. The aim of the present study was to evaluate the efficacy of microneedling using meso-depigmentation solution (mesoneedling) in comparison with standard microneedling, over a 4-month treatment period.Methods: As a part of this pilot study, 20 patients received microneedling on one side and mesoneedling on another side of their face. Treatment was repeated on a monthly basis for 4 months. Treatment efficacy was defined through Dermacatch ® colorimetry, modified Melasma Area and Severity (mMASI) score determination, Investigator's Global Assessment (IGA), and patient questionnaires, whereby all assessments were conducted at the baseline, as well after 2 and 4 months of treatment.Results: Before treatments, mean difference between pigmented and normal skin calculated by Dermacatch ® was 43.7 ± 20.12 and 44.6 ± 20.72 in microneedling sides and mesoneedling sides, respectively. After two and four sessions, these values declined to 34.5 ± 16.26 and 28.05 ± 13.79 on the side subjected to microneedling, while 29.75 ± 15.07 and 20.45 ± 10.58 were measured on the mesoneedling side. Statistically significant differences have been observed between microneedling and mesoneedling treatments at both time points (P = .0001, P = .0001). The mMASI scores obtained upon treatment completion were significantly lower on both the microneedling and the mesoneedling side. The IGA and patients' self-assessment scores further confirmed that both treatments were effective in treating melasma, without producing any notable side-effects or complications. Conclusion:In sum, both microneedling and mesoneedling are effective in decreasing melanin content in the epidermal melasma lesions.

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Section: Introductionmentioning

confidence: 99%

Study of efficacy of microneedling and mesoneedling in the treatment of epidermal melasma: A pilot trial

Farshi

Mansouri

2020

J of Cosmetic Dermatology

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“…Skin restructure leads to a thicker skin. The efficiency of the microneedling mechanism for skin restructuring relies on the natural wound healing process which triggers the generation of growth factors, such as alpha and beta (TGF‐α and TGF‐β), the connective tissue activating protein, the connective tissue growth factor, and the fibroblast growth factor (FGF) 16 . Overall, the wound healing after microneedling increased cell activity, release of various proteins, potassium, and growth factors from the cells into the exterior layer, leading to the migration of fibroblasts to the site of the injury and collagen induction 17 .…”

Section: Discussionmentioning

confidence: 99%

A microneedling device for the treatment of spider vein: A case report

Mohammadnejad

2020

J of Cosmetic Dermatology

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Spider vein is mostly seen in patients with liver disease, although the underlying problem is sometimes unknown. If spider vein appears on the face, it can affect the self‐esteem and self‐image of patients. Particularly, females are more vulnerable to these complications. Spider nevi are mostly left untreated since they are considered a cosmetic matter; in case of treatment, the procedure is costly with limited satisfaction. Therefore, this study reports the successful treatment of a spider vein case using a microneedling procedure.

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“…Melasma is a type of acquired hyperpigmentation disorder that affects the photoexposed parts of the face and significantly influences the quality of life of those who suffer from it [84,85]. Microneedling plays a role in the treatment of melasma by facilitating the delivery of topical therapies to the epidermis and dermis [85][86][87]. For instance, Lima et al [87] evaluated the effectiveness of microneedling performed with a Dermaroller ® (Dr. Roller ® Mooham Enterprise, Gyeonggi-do, Republic of Korea) with a needle length of 1500 µm, with a combination of depigmentation therapy and sunscreen in treating 22 patients with recalcitrant melasma that was unresponsive to topical lightening and sunscreen.…”

Section: Treatment Of Melasmamentioning

confidence: 99%

“…The skin's reaction to microneedling differs between melasma and vitiligo due to their distinct pathophysiology [90]. In melasma, microneedling may help by stimulating collagen production and facilitating the penetration of topical medications, potentially leading to improvement in hyperpigmented spots [86,87]. Additionally, microneedling may induce controlled injury, triggering a healing response that could lead to melanocyte activation and pigment dispersion [84].…”

Section: Treatment Of Melasmamentioning

confidence: 99%

Recent Advances in Microneedling-Assisted Cosmetic Applications

Hamed,

Abu Nahia,

Alkilani

et al. 2024

Cosmetics

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Microneedling, also known as percutaneous collagen induction, using microneedling devices and fabricated microneedle patches, has been widely employed in cosmetic applications for acne scar treatment, skin care, hair loss, melasma, skin rejuvenation, and skin cancer. The micro-channels formed by microneedling through the stratum corneum facilitate the delivery of cosmetic agents and stimulate collagen and elastin production by inducing the wound-healing cascade, keeping the skin shiny and wrinkle-free. Several cosmetic agents, such as ascorbic acid, hyaluronic acid, retinoids, niacinamide, and peptides, have been delivered by microneedling. This review aims to highlight the use of microneedling devices and fabricated microneedle patches in facilitating the delivery of cosmetic agents through the skin layers. Moreover, the differences between the microneedling devices, commonly used alone or in combinational treatments with topical formulations, are explored. Furthermore, the safety of microneedling in terms of skin irritation, pain sensation, skin or systemic infection, and chemical and biological materials used in the fabrication of microneedles is discussed.

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Microneedles: a therapeutic alternative in melasma

Cited by 4 publications

References 21 publications

Study of efficacy of microneedling and mesoneedling in the treatment of epidermal melasma: A pilot trial

Study of efficacy of microneedling and mesoneedling in the treatment of epidermal melasma: A pilot trial

A microneedling device for the treatment of spider vein: A case report

Recent Advances in Microneedling-Assisted Cosmetic Applications

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