Microneedles for advanced ocular drug delivery

Glover, Katie; Mishra, Deepakkumar; Gade, Shilpkala; Vora, Lalitkumar K.; Wu, Yu; Paredes, Alejandro J.; Donnelly, Ryan F.; Singh, Thakur Raghu Raj

doi:10.1016/j.addr.2023.115082

Cited by 33 publications

(18 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They enable localized drug delivery in ocular DDSs, enhancing penetration through ocular barriers for improved therapy. MNs are minimally invasive, making them more acceptable to patients than intravitreal injections [165]. MNs come in various types based on their shape and drug delivery method: (1) Solid MNs create micro-holes to enhance drug permeability.…”

Section: Clinical Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Liu,

Chen,

2023

IJMS

View full text Add to dashboard Cite

Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology and biomaterial science, primarily due to the intricate anatomical and physiological barriers unique to the eye. In this comprehensive review, we aim to shed light on the anatomical and physiological features of the eye, emphasizing the natural barriers it presents to drug administration. Our goal is to provide a thorough overview of various characteristics inherent to each nano-based drug delivery system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, and innovative gene therapy approaches employing nano-based ocular delivery techniques. We delve into the biology and methodology of these systems, introducing their clinical applications over the past decade. Furthermore, we discuss the advantages and challenges illuminated by recent studies. While nano-based drug delivery systems for ophthalmic formulations are gaining increasing attention, further research is imperative to address potential safety and toxicity concerns.

show abstract

Section: Clinical Applicationsmentioning

confidence: 99%

“…Regulatory approvals, standardization, and manufacturing costs are also factors to consider. More clinical studies and safety assessments are needed to establish their effectiveness and safety [165,167].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Liu,

Chen,

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Microneedle (MN) technology consists of an array of needles in a micrometer size ranging up to 2 mm in height [ 1 ]. MNs deliver active pharmaceutical agents or drugs into the human body by piercing micrometer holes into the skin with minimally invasive action [ 2 , 3 , 4 , 5 ]. MN technology provides several benefits compared to traditional patches and syringe injections, which include a painless experience [ 6 ], ease of use [ 7 ], a reduced chance of infection [ 8 ], and capacity for self-administration [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…With the increase in the demand for healthcare applications and services, the market size of medical devices was about $600 billion in 2022 and is estimated to reach above $950 billion by 2031 [ 26 ]. The market share of MNs also has a significant impact on the healthcare and medical industries as it has applications in a wide range of areas [ 4 ] [ 27 , 28 , 29 ]. According to a recent report, the market size of global microneedle drug delivery systems was about $2.65 billion in 2021 and about $2.83 billion in the following year [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Aldawood,

Parupelli,

Andar

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Microneedle (MN) technology is an optimal choice for the delivery of drugs via the transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine delivery, and disease diagnostics. The MN is a biomedical device that offers many advantages including but not limited to a painless experience, being time-effective, and real-time sensing. This research implements additive manufacturing (AM) technology to fabricate MN arrays for advanced therapeutic applications. Stereolithography (SLA) was used to fabricate six MN designs with three aspect ratios. The MN array included conical-shaped 100 needles (10 × 10 needle) in each array. The microneedles were characterized using optical and scanning electron microscopy to evaluate the dimensional accuracy. Further, mechanical and insertion tests were performed to analyze the mechanical strength and skin penetration capabilities of the polymeric MN. MNs with higher aspect ratios had higher deformation characteristics suitable for penetration to deeper levels beyond the stratum corneum. MNs with both 0.3 mm and 0.4 mm base diameters displayed consistent force–displacement behavior during a skin-equivalent penetration test. This research establishes guidelines for fabricating polymeric MN for high-accuracy and low-cost 3D printing.

show abstract

“…Modern strategies like nanoparticles, liposomes, exosomes, smart contact lenses, microneedles, and ocular inserts have been introduced to improve therapeutic e ciency and overcome these biological constraints [8][9][10][11][12]. One of the emerging techniques to produce ocular inserts that have unique features favorable for ophthalmic administration is the nano bers (NFs) electrospinning technology [13].…”

Section: Introductionmentioning

confidence: 99%

Rosuvastatin-laden Nanofibrous Patches for Effective Treatment of Corneal Ulcer in Experimental Animals

Helmy,

Hamed,

Abdelghany

et al. 2023

Preprint

View full text Add to dashboard Cite

Corneal ulceration is a "silent epidemic" that impacts laborers’ lives, particularly in low-income countries, and calls for a unique ophthalmic drug delivery strategy that overcomes ocular barriers to promptly achieve therapeutic outcomes while remaining cost-effective. Rosuvastatin, a third-generation statin that significantly accelerates tissue regeneration and wound healing, could be proposed as a potential treatment for corneal ulcers. Based on these pillars, the current study aims to develop a nanofibers-based corneal patch laden with rosuvastatin, for the first time, as a novel approach for the treatment of corneal ulcers. Several characterizations were performed for the rosuvastatin-laden nanofibers (e.g., drug encapsulation efficiency, drug loading capacity, morphological analysis, elemental mapping, compatibility with other ingredients, and in vitro release studies) indicating the nanofibers' feasibility for the stated purpose. The therapeutic effects of rosuvastatin-laden nanofibers were examined on a surgically generated corneal ulcer rabbit model. The treatment outcomes were evaluated both macroscopically (e.g., corneal opacity degree and area of ulceration) and histologically demonstrating that the rosuvastatin-laden nanofibers heal corneal ulcers promptly. In light of this, the study emphasizes that rosuvastatin has a significant potential for healing corneal ulcers and that fast-release nanofibers may be an ideal drug delivery platform for treating corneal diseases topically.

show abstract

Microneedles for advanced ocular drug delivery

Cited by 33 publications

References 117 publications

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Rosuvastatin-laden Nanofibrous Patches for Effective Treatment of Corneal Ulcer in Experimental Animals

Contact Info

Product

Resources

About