Microneedles for Transdermal Drug Delivery

Migdadi, Eman M.; Donnelly, Ryan F.

doi:10.1002/9783527814633.ch10

Cited by 7 publications

(6 citation statements)

References 280 publications

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“…Microporation is one of the most common invasive physical methods applied for skin barrier removal. Such a method allows the formation of micropores or even microchannels in the skin by the usage of microneedles fabricated of different materials and geometries ( Migdadi and Donnelly, 2019 ; Waghule et al, 2019 ) or laser and radiofrequency ablations, which allows for further transferring of water-soluble molecules and macromolecules ( Sintov et al, 2003 ; Szunerits and Boukherroub, 2018 ), as well as particulate systems ( Genina et al, 2013 ; Belikov et al, 2015 ; Lee W. R. et al, 2015 ; Genina et al, 2016 ; Engelke et al, 2018 ). Such techniques enable the delivery of much larger molecules with much greater fluxes into the skin than other methods and therefore are extensively developed for delivery of insulin ( Fang et al, 2004 ), hormones ( Song et al, 2018 ), vaccines ( Weiss et al, 2012 ), etc.…”

Section: Combination Of Nanocarriers and Physical Methods For Enhanced Transdermal Deliverymentioning

confidence: 99%

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Yang

et al. 2021

Front. Bioeng. Biotechnol.

227

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The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications. The skin also works as a reservoir, thus deliver the penetrated drug for more extended periods in a sustained manner. It reduces toxicity and local irritation due to multiple sites for absorption and owes the option of avoiding systemic side effects. However, the transdermal route of delivery for many drugs is limited since very few drugs can be delivered at a viable rate using this route. The stratum corneum of skin works as an effective barrier, limiting most drugs’ penetration posing difficulty to cross through the skin. Fortunately, some non-invasive methods can significantly enhance the penetration of drugs through this barrier. The use of nanocarriers for increasing the range of available drugs for the transdermal delivery has emerged as a valuable and exciting alternative. Both the lipophilic and hydrophilic drugs can be delivered via a range of nanocarriers through the stratum corneum with the possibility of having local or systemic effects to treat various diseases. In this review, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers used for transdermal delivery, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed. Some recent examples of the combination of nanocarrier and physical methods, including iontophoresis, ultrasound, laser, and microneedles, have also been discussed for improving the therapeutic efficacy of transdermal drugs. Limitations and future perspectives of nanocarriers for transdermal drug delivery have been summarized at the end of this manuscript.

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Section: Combination Of Nanocarriers and Physical Methods For Enhanced Transdermal Deliverymentioning

confidence: 99%

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Yang

et al. 2021

Front. Bioeng. Biotechnol.

227

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“…An exhaustive review by Larrañeta et al described several MN designs/devices with the capacity to play a significant role in modern health care practices. Bariya et al explored the number of MN designs and drug delivery systems, and several reviews were published on the types and fabrication of MNs. ,,− Different categories of MNs have been fabricated with different properties, and each type of needle has its way of drug delivery into the epidermis. Some have used only to create the micropores (solid), some for pre-coated with drugs (coated-solid MNs), some were pre-filled with drugs or continuously sample body fluid (hollow), while some others are dissolvable (dissolving polymeric MNs) and hydrogel-forming MNs.…”

Section: Minimally Invasive Microneedle Glucose Monitoringmentioning

confidence: 99%

Skin Patchable Sensor Surveillance for Continuous Glucose Monitoring

Manasa¹,

Mascarenhas²,

Shetti

et al. 2022

ACS Appl. Bio Mater.

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Diabetes mellitus is a physiological and metabolic disorder affecting millions of people worldwide, associated with global morbidity, mortality, and financial expenses. Long-term complications can be avoided by frequent, continuous self-monitoring of blood glucose. Therefore, this review summarizes the current state-of-art glycemic control regimes involving measurement approaches and basic concepts. Following an introduction to the significance of continuous glucose sensing, we have tracked the evolution of glucose monitoring devices from minimally invasive to non-invasive methods to present an overview of the spectrum of continuous glucose monitoring (CGM) technologies. The conveniences, accuracy, and cost-effectiveness of the real-time CGM systems (rt-CGMs) are the factors considered for discussion. Transdermal biosensing and drug delivery routes have recently emerged as an innovative approach to substitute hypodermal needles. This work reviews skin-patchable glucose monitoring sensors for the first time, providing specifics of all the major findings in the past 6 years. Skin patch sensors and their progressive form, i.e., microneedle (MN) array sensory and delivery systems, are elaborated, covering self-powered, enzymatic, and non-enzymatic devices. The critical aspects reviewed are material design and assembly techniques focusing on flexibility, sensitivity, selectivity, biocompatibility, and user-end comfort. The review highlights the advantages of patchable MNs' multi-sensor technology designed to maintain precise blood glucose levels and administer diabetes drugs or insulin through a "sense and act" feedback loop. Subsequently, the limitations and potential challenges encountered from the MN array as rt-CGMs are listed. Furthermore, the current statuses of working prototype glucose-responsive "closed-loop" insulin delivery systems are discussed. Finally, the expected future developments and outlooks in clinical applications are discussed.

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“…Microporation is one of the most common invasive physical methods applied for the skin barrier removal. Such a method allows the formation of micropores or even microchannels in the skin by the usage of microneedles fabricated of different materials and geometries [107, 108] or laser and radiofrequency ablations, which allows for further transferring of water-soluble molecules and macromolecules [106, 109], as well as particulate systems [110-114]. Such techniques enable the delivery of much larger molecules with much greater fluxes into the skin than other methods and therefore are extensively developed for delivery of insulin [115], hormones [116], vaccines [117], etc.…”

Section: Physical and Chemical Strategies To Enhancement Of Intra- Anmentioning

confidence: 99%

Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs

Lengert¹,

Тальникова²,

Tuchin³

et al. 2020

Skin Pharmacol Physiol

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Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- and transdermal penetration and accumulation of antifungal drugs is an important aspect here. The present overview is focused on novel nano-based formulations served to improve antimycotic penetration through the skin. Furthermore, it summarizes various approaches towards the stimulation of drug penetration through and into the stratum corneum and hair follicles, which are considered to be promising for the future improvement of superficial antifungal therapy as providing the drug localization and prolonged storage property at the targeted area.

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Microneedles for Transdermal Drug Delivery

Cited by 7 publications

References 280 publications

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Skin Patchable Sensor Surveillance for Continuous Glucose Monitoring

Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs

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