Microneedles – Minimally Invasive Transdermal Delivery Technology

Kaushik, Diksha; Kilfoyle, Brian E.; Thakur, Rashmi; Michniak‐Kohn, Bozena

doi:10.1016/b978-0-8155-2025-2.10006-x

Cited by 6 publications

(4 citation statements)

References 41 publications

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“…Different technical approaches, fabrication procedures, geometries and materials from metals to biodegradable polymers are combined in a continuous effort to optimize and expand the medical applications of microneedles [162,163]. Controlled and reliable drug delivery across the microneedles-breached skin barrier can be achieved with enough deformable and stable nano-sized carriers, which are typically composite colloids [49].…”

Section: Nanosized Polymer Systemsmentioning

confidence: 99%

Nanotechnology approaches for pain therapy through transdermal drug delivery

Peptu¹,

Rotaru²,

Ignat³

et al. 2015

CPD

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The paper focuses on the advances in the field of pain treatment by transdermal delivery of specific drugs. Starting from a short description of the skin barrier, the pharmacodynamics and pharmacokinetics including absorption, distribution, action mechanism, metabolism and toxicity, aspects related to the use of pain therapy drugs are further discussed. Most recent results on topical anesthetic agents as well as the methods proved to overcome the skin barrier and to provide efficient delivery of the drug are also discussed. The present review is proposing to summarize the recent literature on the pharmacotherapeutic principles of local anesthetics and non-steroidal anti-inflammatory drugs, generally used to alleviate pain but also the drugs as nanoformulations with potential applications in transdermal delivery. A special attention is given to efficient formulations meant for transdermal penetration enhancement of anesthetics where the drug is encapsulated into macrocyclic molecules (cyclodextrins, cyclodextrin derivatives), liposomes or polymer nanoparticles and hydrogels.

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Section: Nanosized Polymer Systemsmentioning

confidence: 99%

Nanotechnology approaches for pain therapy through transdermal drug delivery

Peptu¹,

Rotaru²,

Ignat³

et al. 2015

CPD

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“…SN application, with ultrasound energy at frequencies in the range of 20 kHz-16 MHz and intensities up to 14 W/cm 2 , enhances skin permeation of high molecularweight drugs. In particular, transdermal enhancement is significantly higher at low-frequency regimens (20 kHz-100 kHz) compared to induction by high-frequency ultrasound (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) MHz) [15].…”

Section: Introductionmentioning

confidence: 97%

“…MNs design can be commonly divided into 3 types: solid MNs, hollow MNs, and biodegradable MNs. Different materials have been used in the fabrication of MNs, including silicon rubber, stainless steel, titanium, glass, polysaccharide, and numerous polymers [6,7]. Moreover, MNs are of interest primarily because they offer the promise of less invasive and painless drug delivery as MNs do Page 3 of 23 not penetrate the papillary layer of dermis where nerve endings are located [7].…”

Section: Introductionmentioning

confidence: 99%

“…Different materials have been used in the fabrication of MNs, including silicon rubber, stainless steel, titanium, glass, polysaccharide, and numerous polymers [6,7]. Moreover, MNs are of interest primarily because they offer the promise of less invasive and painless drug delivery as MNs do Page 3 of 23 not penetrate the papillary layer of dermis where nerve endings are located [7]. In addition to increasing transdermal delivery, a combination of physical enhancement methods should also reduce the level of the enhancers required to achieve the desirable drug flux [8].…”

Section: Introductionmentioning

confidence: 99%

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Transdermal delivery of fluorescein isothiocyanate-dextrans using the combination of microneedles and low-frequency sonophoresis

Pamornpathomkul

Duangjit

Laohapatarapant

et al. 2015

Asian Journal of Pharmaceutical Sciences

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This study aimed to evaluate the patient-friendly methods that are used in the delivery of hydrophilic macromolecules into deep skin layers, in particular, the combination of microneedles patch (MNs patch) and low-frequency sonophoresis (SN). The hydrophilic macromolecule drug fluorescein isothiocyanate (FITC)-dextrans (FD-4: MW 4.4 kDa) was used as the model drug in our experimental design. In this study, excised porcine skin was used to investigate and optimize the key parameters that determine effective MNs-and SN-facilitated FD-4 delivery. In vitro skin permeation experiments revealed that the combination of MNs patch with SN had a superior enhancing effect of skin permeation for FD-4 compared to MNs alone, SN alone or untreated skin, respectively. The optimal parameters for the combination of MNs and SN included the following: 10 N insertion force of MNs, 4 W/cm 2 SN intensity, 6 mm radiation diameter of the SN probe, 2 min application time, and the continuous mode duty cycle of SN. In addition, vertical sections of skin, clearly observed under a confocal microscope, confirmed that the combination of MNs and SN enhanced permeation of FD-4 into the deep skin layers. These studies suggest that the combination of MNs and SN techniques could have great potential in the delivery of hydrophilic macromolecules into deep skin.

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Microneedle Patch Delivery of Capsaicin‐Containing α‐Lactalbumin Nanomicelles to Adipocytes Achieves Potent Anti‐Obesity Effects

Bao

Liang

et al. 2021

Adv Funct Materials

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The development of a minimally invasive therapy for local targeting of adipose tissues could represent an attractive approach for treating obesity. Here, the development and successful application of a nanomedicine that uses α‐lactalbumin (α‐lac) nanomicelles (M) to encapsulate the known anti‐obesity agent capsaicin (Cap), which is delivered directly to adipose tissue via a microneedle patch (MP), is reported. Testing with a 3T3‐L1 adipocyte model shows that M (Cap) reduces lipid droplet content by regulating adipogenesis and improving mitochondrial biogenesis. The MP enables efficient M (Cap) penetration into abdominal subcutaneous adipose tissue, and M (Cap) can be endocytosed by white adipocytes. Experiments using a high fat diet‐induced obese mice model shows that MP‐delivered M (Cap) confers dramatic weight loss and adipose tissue browning, and follow‐up mechanistic investigations indicate (among other impacts) activated energy metabolism, increased mitochondrial biogenesis, and the induction of well‐known adipocyte browning markers. The study supports that MP‐M (Cap) treatment, which could be developed as a self‐administered therapy based on skin attachment for around 30 min, has a promising future as a non‐invasive approach for treating obesity.

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Microneedles – Minimally Invasive Transdermal Delivery Technology

Cited by 6 publications

References 41 publications

Nanotechnology approaches for pain therapy through transdermal drug delivery

Nanotechnology approaches for pain therapy through transdermal drug delivery

Transdermal delivery of fluorescein isothiocyanate-dextrans using the combination of microneedles and low-frequency sonophoresis

Microneedle Patch Delivery of Capsaicin‐Containing α‐Lactalbumin Nanomicelles to Adipocytes Achieves Potent Anti‐Obesity Effects

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