Microneedling: A Comprehensive Review

Hou, Angela Yung Chi; Cohen, Beverly S.; Haimovic, Adele; Elbuluk, Nada

doi:10.1097/dss.0000000000000924

Cited by 135 publications

(130 citation statements)

References 50 publications

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“…Another adjunctive treatment is microneedling or mesotherapy, which creates small channels in the skin to deliver small amounts of topical drugs intradermally [ 56 , 58 , 88 ]. The skin punctures induced by microneedling can also stimulate a beneficial wound-healing response with fewer side effects compared to conventional resurfacing procedures [ 89 ].…”

Section: Introductionmentioning

confidence: 99%

Melasma: an Up-to-Date Comprehensive Review

Ogbechie-Godec

Elbuluk

2017

Dermatol Ther (Heidelb)

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252

210

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Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1–50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates. Various topical, oral, and procedural therapies have been successfully used to treat melasma. Traditional topical therapies including hydroquinone, tretinoin, corticosteroids, and triple combination creams; however, other synthetic and natural topical compounds have also shown varying efficacies. Promising oral therapies for melasma include tranexamic acid, Polypodium leucotomos, and glutathione. Procedures, including chemical peels, microneedling, radiofrequency, and lasers, are also often used as primary or adjunctive treatments for melasma. Notably, combination therapies within or across treatment modalities generally result in better efficacies than monotherapies. This review serves as a comprehensive update on the current understanding of the epidemiology, pathogenesis, clinical and histologic features of melasma, as well as treatments for this common, yet therapeutically challenging, condition.

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Section: Introductionmentioning

confidence: 99%

Melasma: an Up-to-Date Comprehensive Review

Ogbechie-Godec

Elbuluk

2017

Dermatol Ther (Heidelb)

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252

210

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“…Dissolvable but also permanent, MNs have been www.advancedsciencenews.com www.advtherap.com demonstrated to be well tolerated and easy to use. [51][52][53] MN-based insulin delivery systems are reviewed in the paper of Chen et al, which reports on the full chain from the materials to the commercial devices available on the market. [49,50] In both cases, the self-administration and painlessness of MNs greatly improved the efficacy of treatments.…”

Section: Translational Challengesmentioning

confidence: 99%

“…Exhaustive reviews on dermatological studies involving humans can also be found in the recent literature. [51][52][53] MN-based insulin delivery systems are reviewed in the paper of Chen et al, which reports on the full chain from the materials to the commercial devices available on the market. [54] Finally, the most relevant paper published in the field describes the results of a phase 1 clinical trial study on human vaccination against influenza.…”

Section: Translational Challengesmentioning

confidence: 99%

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

Dardano

Battisti²,

Rea

et al. 2019

Advanced Therapeutics

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Mainly designed and realized as a painless alternative to the hypodermic syringe, microneedle-based devices are currently approaching commercial market placement. The considerable academic and industrial investment in this technology is reflected by a multitude of papers published and patents registered every year, which is also a sign of a field in full fermentation. New materials and innovative methodologies are continuously exploited in search of the best performance at the lowest cost. For these reasons, an updated review, focused predominantly on the last year of scientific production, is a useful guideline in this rapidly changing panorama. This report provides a critical review of microneedle technologies presented in the very recent literature with a particular focus on those closest to the needs of the healthcare field. Although a few devices are already commercial, further effort is still needed to achieve complete clinical translation and therapeutic efficacy competitive with or superior to those of the devices used as standards and adopted by national health systems.

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“…Microneedling, a term familiar to most dermatologists today, has continuously evolved since its inception in the early twentieth century. The technique of microneedling is built upon non-pathogenic puncturing of the skin with micro-sized needles, thereby stimulating the underlying cells to increase the production of growth factors and the vital dermal ingredient, collagen (Aust et al 2008 ; Hou et al 2017 ). The use of microneedles is painless relative to the conventional hypodermic needles since they cannot penetrate the dermis layer (Azmana et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery

Dsouza

Ghate

Lewis

2020

Biomed Microdevices

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Derma roller, a device rolled onto the skin to form micropores, is extensively used for cosmetic purposes. The pores thus created are utilized to either result in the induction of collagen production, leading to glowing and wrinkle-free skin or for permeating the applied formulations to the site of action within the skin. Recent studies have shown the benefits of using derma rollers for transdermal delivery of drugs. In the nascent stage, this approach paves a way to successfully breach the stratum corneum and aid in the movement of medications directed towards the dermis and the hair follicles. The review essentially summarizes the evidence of the use of derma rollers in cosmetic setup, their designing, and the preclinical and clinical reports of efficacy, safety, and concerns when translated for pharmaceutical purposes and transdermal drug delivery.

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Microneedling: A Comprehensive Review

Abstract: Microneedling appears to be an overall effective and safe therapeutic option for numerous dermatologic conditions. Larger and more randomized controlled trials are needed to provide greater data on the use of microneedling for different dermatologic conditions in different skin types.

Cited by 135 publications

References 50 publications

Melasma: an Up-to-Date Comprehensive Review

Melasma: an Up-to-Date Comprehensive Review

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery

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