Microneedling combined with pimecrolimus, 5‐fluorouracil, and trichloroacetic acid in the treatment of vitiligo: A comparative study

Abstract

Treatment of vitiligo represents a highly therapeutic challenge in spite of the continuous development of new modalities. Combination therapies of vitiligo can help improve treatment response, and reduce recurrence potential. To compare the efficacy and adverse effects of microneedling combined with-fluorouracil, pimecrolimus, and trichloroacetic acid (TCA) in the treatment of localized, stable vitiligo. The study included 75 patients with non-segmental, stable vitiligo who were randomly assigned to three equal groups: group received a combination of microneedling and -FU, group 2 received microneedling and pimecrolimus, and group 3 received microneedling and TCA. The procedure was done every 2 weeks for a maximum of six sessions. Combined microneedling and TCA was associated with the highest + 5-fluorouracil, and lastly combined microneedling + pimecrolimus. The difference between the three groups was statistically significant in favor of the combined microneedling and TCA.Pain, erythema, post-inflammatory hyperpigmentation, infection, and scarring were variably reported adverse effects in the three groups. Combination therapy seems to be a promising modality for the treatment of vitiligo. Combined microneedling and TCA is superior to combined microneedling with either-fluorouracil or pimecrolimus.

[Retracted] Clinical Effect of Microneedle Injection Combined with Blood Transfusion in the Treatment of Severe Anemia Complicated with Vitiligo under Regenerative Medical Technology

“…In recent years, with the continuous improvement of the medical level, microneedle therapy has been gradually known and widely used in the medical field. Nofal et al [30] found that the microneedle had the characteristics and advantages of precisely adjustable depth and realtime monitoring, and the depth and energy of the micro-needle could be adjusted according to the different degrees by penetrating the skin with the microneedle. The tip of the microneedle penetrated the skin to introduce drugs, which not only improved the utilization value of drugs to achieve the effect of targeted therapy but also effectively avoided epidermal stimulation.…”

Efficacy of Cefazolin in the Treatment of Pregnancy and Vaginal GBS Infection and Its Influence on Inflammation and Maternal and Infant Outcomes

“…Group B streptococcus is a common pathogen, mainly infecting pregnant women and newborns, which may lead to maternal and infant infection, premature delivery, and even death. Therefore, timely use of antibiotics in the perinatal period can effectively inhibit and kill pathogens such as GBS and reduce the risk of maternal and infant infection [8][9][10].…”

Vitiligo: Pathogenesis and New and Emerging Treatments

“…Regarding reported efficacy, Nofal et al [63] published a 100-patient study reporting an 80% response rate in eyelid vitiligo, with a lower response rate in the face, torso and extremities with the application of variable concentrations of TCA every 2 weeks for 12 months. Two studies investigated the combination of microneedling and TCA, interestingly finding better response rates with the application of 70% TCA [65] than with 100% TCA [66]. The single application of 15% TCA in combination with NB-UVB achieved an excellent response in 70% of patients in a clinical trial [67].…”