Micronization of Fluticasone Propionate using Supercritical Antisolvent (SAS) Process

Su, Chie-Shaan; Lo, Wei-Shuo; Lien, Ling-Hsiao

doi:10.1002/ceat.201000462

Cited by 21 publications

(9 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27 Previous researchers have also reported similar results. 28,29 effect of concentration of solution As indicated in Figures 4 and 5, the concentration of solution had a slight effect on particle size; hence, the higher the concentration of solution, the smaller the particle size. Runs 6 and 14 (Table 2) showed that an increase in the concentration of curcumin solution from 0.5% to 1% can decrease the size of curcumin nanoparticles from 386 to 334 nm.…”

mentioning

confidence: 92%

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Zhao¹,

Xie²,

Li³

et al. 2015

IJN

138

View full text Add to dashboard Cite

In order to enhance the bioavailability of poorly water-soluble curcumin, solution-enhanced dispersion by supercritical carbon dioxide (CO 2 ) (SEDS) was employed to prepare curcumin nanoparticles for the first time. A 2 4 full factorial experiment was designed to determine optimal processing parameters and their influence on the size of the curcumin nanoparticles. Particle size was demonstrated to increase with increased temperature or flow rate of the solution, or with decreased precipitation pressure, under processing conditions with different parameters considered. The single effect of the concentration of the solution on particle size was not significant. Curcumin nanoparticles with a spherical shape and the smallest mean particle size of 325 nm were obtained when the following optimal processing conditions were adopted: P =20 MPa, T =35°C, flow rate of solution =0.5 mL·min −1 , concentration of solution =0.5%. Fourier transform infrared (FTIR) spectroscopy measurement revealed that the chemical composition of curcumin basically remained unchanged. Nevertheless, X-ray powder diffraction (XRPD) and thermal analysis indicated that the crystalline state of the original curcumin decreased after the SEDS process. The solubility and dissolution rate of the curcumin nanoparticles were found to be higher than that of the original curcumin powder (approximately 1.4 μg/mL vs 0.2 μg/mL in 180 minutes). This study revealed that supercritical CO 2 technologies had a great potential in fabricating nanoparticles and improving the bioavailability of poorly water-soluble drugs.

show abstract

mentioning

confidence: 92%

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Zhao¹,

Xie²,

Li³

et al. 2015

IJN

138

View full text Add to dashboard Cite

show abstract

“…SAS particles can be used for oral, parenteral, and topical drug administration; in the latter case, the micronized drug particles can be incorporated into various types of dressings or supports. Up to now, SAS-micronized drugs were proposed for different diseases or clinical conditions, including inflammations and pains [11,12,75,84], infections [2,4,25,58,59,61,63,64,74,77,85,86], diabetes [5,7,66], psychological disorders [87], asthma [32,71,88], tumors [1,3,4,31,38,[67][68][69]78,[89][90][91][92], cardiovascular pathologies [6,33,70,76], etc.…”

Section: Sas Micronization Of Active Compoundsmentioning

confidence: 99%

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Franco

Marco

2020

Processes

View full text Add to dashboard Cite

The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathologies and to better the patient’s compliance. In this context, many active compounds have been micronized to enhance their dissolution rate and bioavailability. Aiming for more effective treatments with reduced side effects caused by drug overdose, the SAS polymer/active principle coprecipitation has mainly been proposed to offer an adequate drug release for specific therapy. The demand for new formulations with reduced side effects on the patient’s health is still growing; in this context, the SAS technique is a promising tool to solve existing issues in the biomedical field. This updated review on the use of the SAS process for clinical applications provides useful information about the achievements, the most effective polymeric carriers, and parameters, as well as future perspectives.

show abstract

“…One of the widely used crystallization processes is solventantisolvent crystallization (SAC), which reduces the size [13,14] and changes the morphology of high-energy materials [15][16][17][18]. In SAC, the solute and antisolvent can be dissolved in the solvent, but the solute is insoluble in the antisolvent.…”

Section: Introductionmentioning

confidence: 99%

Taguchi Optimization of Solvent‐Antisolvent Crystallization to Prepare Ammonium Perchlorate Particles

et al. 2020

View full text Add to dashboard Cite

The sphericity and size of ammonium perchlorate (AP) particles significantly influence the properties of composite propellants. As the AP particles become more spherical, the accumulation coefficient increases, the viscosity during casting decreases, and the particle loading and burning rate increase. Hence, the production of micronized AP particles with an average size between 1 and 20 μm is important to increase the loading percentage of AP in the composite propellant. Here, the Taguchi experimental design was used to optimize the solvent-antisolvent crystallization (SAC) process for the preparation of micronized AP particles with higher sphericity. SAC parameters such as the type of antisolvent, the solvent-to-antisolvent ratio, the antisolvent temperature, the stirring speed, and the retention time were investigated at four levels. The type of antisolvent and the solvent-to-antisolvent ratio were found to mainly contribute to improving the sphericity and size of the AP particles, respectively.

show abstract

Micronization of Fluticasone Propionate using Supercritical Antisolvent (SAS) Process

Cited by 21 publications

References 43 publications

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Taguchi Optimization of Solvent‐Antisolvent Crystallization to Prepare Ammonium Perchlorate Particles

Contact Info

Product

Resources

About