Micronutrient Metabolism in Hemodialysis Patients

Guo, Chih-Hung; Wang, Chia-Liang; Chen, Pei-Chung

doi:10.5772/22788

Cited by 8 publications

(10 citation statements)

References 193 publications

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“…Several studies have shown that circulating Se concentrations in patients undergoing hemodialysis and CAPD were lower than those in healthy controls [16,17,35], although conflicting results have been reported [36]. Low Se status may be attributed to reduced Se intake, malnutrition, impaired absorption due to high levels of pro-inflammatory cytokine, diminished Se retention due to chronic oxidative stress, or increased loss of Se in the dialysis effluent [2,37]. Further, GPx is a Se dependent protein and circulating GPx activities are responsive to Se status in the biological systems [38].…”

Section: Discussionmentioning

confidence: 99%

“…Our present results show that patients receiving Zn had higher plasma concentrations of hemoglobin and albumin. Zn supplementation may improve the acuity of taste and smell and gastrointestinal function, increase food intake, and reduce protein-energy wasting [2,30,51]. Thus, The Zn-deficient patients who receive Zn supplementation have improvements in their oxidant-antioxidant balance and nutritional status [13,14], which likely contributes to their increased plasma Se status.…”

Section: Discussionmentioning

confidence: 99%

“…Despite dialysis treatment, these patients still have high morbidity and mortality rates [1]. The major contributing risk factors include wasting, an oxidant-antioxidant imbalance, progressive inflammation, impaired immune responsiveness, and infection [2]. Recent studies have shown that deficiencies in the essential trace elements zinc (Zn) and selenium (Se) are common findings, which predispose patients to the complications noted above [3,4,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Zn is an anti-oxidant, has anti-inflammatory properties, and regulates innate and adaptive immune responses, which makes it crucial for resistance to infection [2]. Zn deficient status is associated with immune system disturbances, poor nutritional status, atherosclerosis, high rates of hospitalization due to infections [7,8,9,10], and significant reductions in blood Se concentrations in chronic dialysis patients [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Se also attenuates inflammatory responses and is required for immune system function [2]. Se deficiency contributes to immune system dysfunction, increases the death from infections, and is a higher cardiovascular disease risk for dialysis patients [16,17].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Zinc Supplementation Alters Plasma Aluminum and Selenium Status of Patients Undergoing Dialysis: A Pilot Study

Guo¹,

Chen²,

Hsu³

et al. 2013

Nutrients

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End stage renal disease patients undergoing long-term dialysis are at risk for abnormal concentrations of certain essential and non-essential trace metals and high oxidative stress. We evaluated the effects of zinc (Zn) supplementation on plasma aluminum (Al) and selenium (Se) concentrations and oxidative stress in chronic dialysis patients. Zn-deficient patients receiving continuous ambulatory peritoneal dialysis or hemodialysis were divided into two groups according to plasma Al concentrations (HA group, Al > 50 μg/L; and MA group, Al > 30 to ≤ 50 μg/L). All patients received daily oral Zn supplements for two months. Age- and gender-matched healthy individuals did not receive Zn supplement. Clinical variables were assessed before, at one month, and after the supplementation period. Compared with healthy subjects, patients had significantly lower baseline plasma Se concentrations and higher oxidative stress status. After two-month Zn treatment, these patients had higher plasma Zn and Se concentrations, reduced plasma Al concentrations and oxidative stress. Furthermore, increased plasma Zn concentrations were related to the concentrations of Al, Se, oxidative product malondialdehyde (MDA), and antioxidant enzyme superoxide dismutase activities. In conclusion, Zn supplementation ameliorates abnormally high plasma Al concentrations and oxidative stress and improves Se status in long-term dialysis patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Zinc Supplementation Alters Plasma Aluminum and Selenium Status of Patients Undergoing Dialysis: A Pilot Study

Guo¹,

Chen²,

Hsu³

et al. 2013

Nutrients

Self Cite

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Increased Serum Al Levels in Hemodialysis Patients Kept Enhanced during a 2-Year Prospective Study

Torre

Serrana

Moral

et al. 2016

Biol Trace Elem Res

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The regulation of mineral homeostasis is altered in hemodialysis patients with renal insufficiency, producing increased risk for secondary diseases like cardiovascular ones. We hypothesized that risen serum aluminum (Al) concentration in hemodialysis patients kept enhanced during a 2-year longitudinal study is associated with enhanced cardiovascular risk and influenced by medical treatments. This study reports the prospective monitoring of serum Al levels in six-monthly samplings over 2 years in 116 hemodialysis patients and a control group of 50 healthy adults. The influence of other factors like sex, age, kidney transplant, disease etiology, and drug consumption was also considered. At each sampling, serum Al levels were significantly higher in the patients than in the healthy controls (P < 0.05). Levels in the patient group were statistically significantly lower at the third and fourth versus first and second samplings, which may be related to Al accumulation in tissues. Increased Al levels in patients were positively and significantly related to serum calcium (Ca) and uric acid levels. Serum Al concentrations were significantly lower in patients receiving vasodilators and diuretics. Higher serum Al levels in hemodialyzed patients administered with phosphate binders or anti-hyperkalemics are attributable to their usual Al salt content. The consumption of antianemic drugs increases Al absorption by forming more bioavailable complexes with the compounds in these drugs. In conclusion, this is the first study to indicate that cardiovascular problems associated with elevated serum Al levels in hemodialysis patients may be in part mitigated by administrating vasodilators and diuretics, which reduce these levels.

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Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea

Chen

Guo

Tseng

et al. 2013

The Journal of nutrition, health and aging

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Micronutrient Metabolism in Hemodialysis Patients

Cited by 8 publications

References 193 publications

Zinc Supplementation Alters Plasma Aluminum and Selenium Status of Patients Undergoing Dialysis: A Pilot Study

Zinc Supplementation Alters Plasma Aluminum and Selenium Status of Patients Undergoing Dialysis: A Pilot Study

Increased Serum Al Levels in Hemodialysis Patients Kept Enhanced during a 2-Year Prospective Study

Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea

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