Micronutrient status influences clinical outcomes of paediatric cancer patients during treatment: A prospective cohort study

Iniesta, Raquel; Gerasimidis, Konstantinos; Paciarotti, Ilenia; McKenzie, Jane; Brougham, Mark; Wilson, David C.

doi:10.1016/j.clnu.2021.03.020

Cited by 14 publications

(18 citation statements)

References 49 publications

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“…Diet was recorded for a median of 28 days (26‐28) with a range from 22 to 28 days (mean 26.7 days, SD 1.8). Median energy provision during the whole diet registration period was 115% (110–123) of BMR.…”

Section: Resultsmentioning

confidence: 99%

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Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Nutritional Status and Intake in Children

Kvammen

Thomassen

Buechner

et al. 2022

J. pediatr. gastroenterol. nutr.

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Objectives: This study aimed to describe the impact of allogeneic/haploidentical hematopoietic stem cell transplantation on nutritional status and intake in a group of children aged 2 to 18 years. Methods: In an observational study, data were collected prospectively. Patients were prescribed individual nutritional support by hospital routines. Anthropometrics were measured pre-transplant at hospital admission and weekly from the day of transplant (day 0) until day +28. z scores for weight, height, and BMI were calculated using Norwegian growth references to assess nutritional status. Pre-transplant diet was assessed on the day of hospitalization. Nutrient provision from enteral nutrition (EN = oral and tube) and parenteral nutrition (PN) was assessed by daily records from day +1 until day +28, or previous discharge, and compared with recommendations (RI) from the Nordic Nutrition Recommendations and ESPGHAN guidelines. Total energy intake was presented as the percentage (%) of basal metabolic rate (BMR) calculated by the Schofield equation. Macro-and micronutrient provisions were presented as medians (interquartile range) and the % of RI. Results: Twenty-eight patients, mean age 10.3 years (range 3.5-16.6), were included. Two-thirds (n = 18) had malignant diseases. At admission, mean weight Z-score was −0.3, height z scores −0.7, and BMI Z-score 0.1. Eighteen percent (n = 5) were stunted and 25% (n = 7) had overweight. At admission, 25% (n = 7) had established tube feeding, and 7% (n = 2) also had PN. No significant changes in weight z scores were detected during the studied weeks (P = 0.454). The median daily energy provision was 115% (110-123) of BMR and proteins 1.5 (1.3-1.8) g/kg. EN was provided during a median of 93% of the studied days and provided 21% of the energy. PN was given on a median of 96% of the studied days and provided 79% of energy. RI for vitamins, magnesium, and zinc was met. Provision of copper, iodine, selenium, calcium, and phosphate was below RI. Conclusions: Combined EN and PN providing 115% of BMR and 1.5 g/kg protein ensured stable weight by day +28 and covered RI, except for trace elements and minerals.

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Section: Resultsmentioning

confidence: 99%

“…Another critical but less studied aspect of nutritional therapy in HSCT is the provision of micronutrients and if recommendations are met. Micronutrient status has been found to influence clinical outcomes of pediatric cancer patients ( 27 ), which might imply that micronutrients also can be essential for HSCT patients.…”

mentioning

confidence: 99%

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Nutritional Status and Intake in Children

Kvammen

Thomassen

Buechner

et al. 2022

J. pediatr. gastroenterol. nutr.

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“…Malnutrition is an unspecific term used to define an inadequate nutritional status characterized by deficiencies, imbalances, or excess of energy and nutrients; it is detrimental to clinical conditions and associated with poor growth and development [15][16][17][18][19][23][24][25][26]. It is known that adequate nutrition is especially important in early childhood and is a prerequisite for the regular functioning of life-sustaining biochemical reactions, an efficient immune function, and for the general well-being of the child [10,[15][16][17][18][19]27].…”

Section: Definition and Prevalence Of Malnutrition In Childhood Cancermentioning

confidence: 99%

“…Malnutrition not only debilitates the body but also influences drug metabolism [11,20,[23][24][25]33]. Minor changes in substance concentration may profoundly impact treatment efficacy as chemotherapeutic drugs have narrow therapeutic indices.…”

Section: Etiology Pathophysiology and Considerable Aspects Of Nutrition In Children With Cancermentioning

confidence: 99%

“…At the same time, the incidence of malnutrition amongst children with cancer is high and both under-and overnutrition are associated with detrimental consequences, including increased risks for morbidity and mortality, early relapse rates, and a higher prevalence of secondary complications during treatment [15][16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Omega-3 Fatty Acids and Their Role in Pediatric Cancer

et al. 2021

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Background: Malnutrition is common in children with cancer and is associated with adverse clinical outcomes. The need for supportive care is becoming ever more evident and the role of nutrition in oncology is still not sufficiently understood. In particular, the consequences of macro- and micronutrient deficiencies require further research. As epidemiological data suggest anti-tumoral properties of omega-3 (n-3) polyunsaturated fatty acids (PUFAs), we reviewed the role of nutrition and n-3 supplementation in pediatric oncology. Methods: A comprehensive literature search was conducted on PubMed through 5 February 2021 to select meta-analyses, systematic reviews, observational studies, and individual randomized controlled trials (RCTs) on macro- and micronutrient supplementation in pediatric oncology. The search strategy included the following medical subject headings (MeSH) and keywords: “childhood cancer”, “pediatric oncology”, “nutritional status”, “malnutrition”, and “omega-3-fatty-acids”. The reference lists of all relevant articles were screened to include potentially pertinent studies. Results: We summarize evidence about the importance of adequate nutrition in childhood cancer and the role of n-3 PUFAs and critically interpret findings. Possible effects of supplementation on the nutritional status and benefits during chemotherapy are discussed as well as strategies for primary and secondary prevention. Conclusion: We here describe the obvious benefits of omega-3 supplementation in childhood cancer. Further large scale clinical trials are required to verify potential anti-cancer effects of n-3 fatty acids.

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Feasibility study of micronutrient status and body mass index of newly diagnosed pediatric oncology patients: Research commentary

Rogers,

Cheng,

Lim

et al. 2024

Pediatric Blood & Cancer

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We conducted a feasibility study to evaluate micronutrients and body mass index (BMI). Fat soluble vitamins A, D, E and trace elements copper (Cu), selenium (Se), and zinc (Zn) levels were evaluated. Weight, height, BMI, and Z‐scores were recorded. Side effects or specific adverse events were documented. No patient had a Z‐score for height, weight, or BMI of less than 2 SD or greater than 2 SD. Ninety percent of patients had one or more micronutrient levels below normal. These results suggest that micronutrient abnormalities are common despite no obvious evidence of malnutrition. Side effects of chemotherapy may be exacerbated by micronutrient depletion.

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Micronutrient status influences clinical outcomes of paediatric cancer patients during treatment: A prospective cohort study

Cited by 14 publications

References 49 publications

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Nutritional Status and Intake in Children

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Nutritional Status and Intake in Children

Omega-3 Fatty Acids and Their Role in Pediatric Cancer

Feasibility study of micronutrient status and body mass index of newly diagnosed pediatric oncology patients: Research commentary

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