Micronutrient Supplementation to Reduce Cardiovascular Risk

An, Peng; Wan, Sitong; Luo, Yongting; Luo, Junjie; Zhang, Xu; Zhou, Shuaishuai; Teng, Xu; He, Jingjing; Mechanick, Jeffrey I.; Wu, Wen‐Chih; Ren, Fazheng; Liu, Simin

doi:10.1016/j.jacc.2022.09.048

Cited by 99 publications

(65 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the role of polyphenols present in different sources (black currant, beet root, pomegranate, everlasting flower) in the prevention of endothelial dysfunction has been elucidated in several studies [ 114 , 115 , 116 , 117 ]. The polyphenols could prevent activation of the angiotensin system, enhance endothelial relaxation by regulating EDH, oxidative stress, and inflammatory response to improve the angiotensin system producing the vasodilation effect [ 112 , 114 , 116 , 118 ].…”

Section: Impacts Of Polyphenols On Human Healthmentioning

confidence: 99%

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Rathod

Abed

Punia³

et al. 2023

Plants

107

View full text Add to dashboard Cite

Polyphenol has been used in treatment for some health disorders due to their diverse health promoting properties. These compounds can reduce the impacts of oxidation on the human body, prevent the organs and cell structure against deterioration and protect their functional integrity. The health promoting abilities are attributed to their high bioactivity imparting them high antioxidative, antihypertensive, immunomodulatory, antimicrobial, and antiviral activity, as well as anticancer properties. The application of polyphenols such as flavonoids, catechin, tannins, and phenolic acids in the food industry as bio-preservative substances for foods and beverages can exert a superb activity on the inhibition of oxidative stress via different types of mechanisms. In this review, the detailed classification of polyphenolic compunds and their important bioactivity with special focus on human health are addressed. Additionally, their ability to inhibit SARS-CoV-2 could be used as alternative therapy to treat COVID patients. Inclusions of polyphenolic compounds in various foods have demonstrated their ability to extend shelf life and they positive impacts on human health (antioxidative, antihypertensive, immunomodulatory, antimicrobial, anticancer). Additionally, their ability to inhibit the SARS-CoV-2 virus has been reported. Considering their natural occurrence and GRAS status they are highly recommended in food.

show abstract

Section: Impacts Of Polyphenols On Human Healthmentioning

confidence: 99%

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Rathod

Abed

Punia³

et al. 2023

Plants

107

View full text Add to dashboard Cite

show abstract

“…An evaluation of the literature would indicate that not all nutritional molecules are equal, given that the needs of patients may well be different. As a result, more personalized and specific integrate dietary interventions involving combinations of beneficial supplements in specific amounts may be needed to stimulate specific anabolic pathways (33). Last but not least, it is necessary to distinguish between being fed, with or without nutritional supplementations, and nutrition itself.…”

Section: Nutritional Supplementationmentioning

confidence: 99%

Nutritional Supplementation and Exercise – Essential Allies in the Treatment of Chronic Heart Failure: The Metabolic and Molecular Bases.

Pasini¹,

Corsetti²,

Dioguardi³

2023

Preprint

View full text Add to dashboard Cite

Malnutrition, clinically evident primarily with sarcopenia, is present in more than 50% of CHF patients and is an independent factor of morbidity and mortality. Several pathophysiological mechanisms, such as reduced appetite, metabolic imbalance and altered protein synthesis/degradation rate, due to the blood increase of hypercatabolic molecules, have been proposed to explain this phenomenon. Nutritional supplementation with proteins, amino acids and vitamins have all been used to treat malnutrition, acting through mTOR stimulation. However, the success and efficacy of these procedures are often contradictory and not conclusive. Interestingly, data on exercise training show that exercise reduces mortality and increase functional capacity, although it also increases energy expenditure and nitrogen providing substrate needs. Therefore, this paper discusses the molecular mechanisms of integrated nutritional approaches that would stimulate metabolic anabolic pathways. Pivotal in our opinion, is the relationship between exercise and Deptor, a subunit of the mTOR complex. Consequently, we propose a combination of personalized and integrate nutritional supplementation as well as exercise to treat malnutrition and related anthropometric and functional CHF-related disorders.

show abstract

“…Moreover, selenite has shown therapeutic effects against cancer, where selenite treatment stimulated cancer cell apoptosis via a mechanism involving enhanced ROS generation and the accumulation of hydrogen peroxide which, ultimately, decreased cell viability [ 20 ]. However, some studies show inconsistent results, where no beneficial effects were determined in intervention studies that increased Se intake in pathologies, including cancer, diabetes, and cardiovascular disease; moreover, Se supplementation correlated with increased occurrences of prostate cancer and diabetes [ 21 , 22 ].…”

Section: Introduction Of Seleniummentioning

confidence: 99%

“…Associations between Se and several other inflammatory disorders have been evaluated. For example, recent research demonstrated the anti-inflammatory role of Se in the millet-derived selenylated soluble dietary fibre [ 22 ] and nanoparticle formulation in a mouse model of inflammatory bowel disease (IBD) [ 23 , 24 , 25 ]. With respect to the latter, dietary Se was demonstrated to maintain intestinal microbiota homeostasis and barrier function in mice with DSS-induced colitis, with Se-mediated colon protective activity characterised by reduced ROS formation, enhanced antioxidant capacity, and dampened intestinal immune response, thereby protecting cellular functions and mitochondrial structures from excessive oxidative stress.…”

Section: Introduction Of Seleniummentioning

confidence: 99%

“…The inconsistency in outcomes documented above is a complex issue due to inherent biological and environmental variations, along with the varying (baseline) Se status of individuals prior to supplementation, and the chemical forms and dosages used in reported Se supplementation studies. Nonetheless, dietary Se supplementation remains a popular option used to promote healthier lifestyles and optimise dietary habits, as enrichment with this micronutrient could potentially promote health benefits in humans [ 22 , 36 ].…”

Section: Introduction Of Seleniummentioning

confidence: 99%

See 1 more Smart Citation

Physiological Benefits of Novel Selenium Delivery via Nanoparticles

Mojadadi

Shao

et al. 2023

IJMS

View full text Add to dashboard Cite

Dietary selenium (Se) intake within the physiological range is critical to maintain various biological functions, including antioxidant defence, redox homeostasis, growth, reproduction, immunity, and thyroid hormone production. Chemical forms of dietary Se are diverse, including organic Se (selenomethionine, selenocysteine, and selenium-methyl-selenocysteine) and inorganic Se (selenate and selenite). Previous studies have largely investigated and compared the health impacts of dietary Se on agricultural stock and humans, where dietary Se has shown various benefits, including enhanced growth performance, immune functions, and nutritional quality of meats, with reduced oxidative stress and inflammation, and finally enhanced thyroid health and fertility in humans. The emergence of nanoparticles presents a novel and innovative technology. Notably, Se in the form of nanoparticles (SeNPs) has lower toxicity, higher bioavailability, lower excretion in animals, and is linked to more powerful and superior biological activities (at a comparable Se dose) than traditional chemical forms of dietary Se. As a result, the development of tailored SeNPs for their use in intensive agriculture and as candidate for therapeutic drugs for human pathologies is now being actively explored. This review highlights the biological impacts of SeNPs on growth and reproductive performances, their role in modulating heat and oxidative stress and inflammation and the varying modes of synthesis of SeNPs.

show abstract

Micronutrient Supplementation to Reduce Cardiovascular Risk

Cited by 99 publications

References 40 publications

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Nutritional Supplementation and Exercise – Essential Allies in the Treatment of Chronic Heart Failure: The Metabolic and Molecular Bases.

Physiological Benefits of Novel Selenium Delivery via Nanoparticles

Contact Info

Product

Resources

About