Micronutrients and Diabetic Retinopathy: Evidence From The National Health and Nutrition Examination Survey and a Meta-analysis

Xiong, Ruilin; Yuan, Yixiong; Zhu, Zhuoting; Wu, Yi; Ha, Jason; Han, Xiaotong; Wang, Wei; He, Miao

doi:10.1016/j.ajo.2022.01.005

Cited by 9 publications

(9 citation statements)

References 76 publications

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“…Regarding DR, while a number of studies found lower serum levels of vitamin D among patients with DR, compared to those without DR [ 32 , 43 , 44 , 45 , 46 , 47 , 48 , 50 ], other studies found no association between vitamin D serum levels and DR status [ 28 , 42 , 57 , 58 , 59 , 61 , 62 , 63 ]. There were four meta-analyses on serum vitamin D levels and DR, and each concluded that there was an association between low serum vitamin D levels and increased risk of development of DR, but there was high heterogenicity in the studies [ 51 , 82 , 83 , 84 ]. There have not yet been meta-analyses of the association between serum levels of other individual vitamins and DR.…”

Section: Discussionmentioning

confidence: 99%

The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review

Ruamviboonsuk

Grzybowski

2022

JCM

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There have been attempts to evaluate the roles of vitamins for the prevention or treatment of eye conditions, such as glaucoma, age-related macular degeneration, and diabetic retinopathy (DR). Regarding DR, two main groups of studies can be identified. The first group focuses on the association between serum levels of an individual vitamin and DR. Many studies have found that lower serum levels of vitamins, particularly vitamin D, are significantly associated with the development, or severity, of DR, while some studies have not supported this trend. The second group evaluates dietary vitamin intakes and DR. A small, randomized placebo-controlled trial did not show any benefit of vitamin E intake on improving the area of retinal hemorrhage or diabetic macular edema at 12 months. A pilot study of patients with mild-to-moderate non-proliferative DR received tablets of combined vitamins B6, B9, and B12 for 6 months and significant improvement in retinal sensitivity and retinal thickness resulted. Two large prospective cohorts showed that high dietary intake of vitamin B6, and fruit rich in vitamin C and E, could significantly lower the risk of DR by 50% after an eight-year follow-up. Properly designed, randomized controlled trials are needed to support the results.

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Section: Discussionmentioning

confidence: 99%

The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review

Ruamviboonsuk

Grzybowski

2022

JCM

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“…However, a recent meta-analysis did not show a significant association between the serum content of lutein, zeaxanthin, and other vitamin A-derivatives with DR [ 104 ].…”

Section: Exogenous Plant-derived Antioxidantsmentioning

confidence: 99%

Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases

Rodella

Honisch

Gatto³

et al. 2023

Nutrients

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This review aims to discuss the delicate balance between the physiological production of reactive oxygen species and the role of antioxidant nutraceutical molecules in managing radicals in the complex anatomical structure of the eye. Many molecules and enzymes with reducing and antioxidant potential are present in different parts of the eye. Some of these, such as glutathione, N-acetylcysteine, α-lipoic acid, coenzyme Q10, and enzymatic antioxidants, are endogenously produced by the body. Others, such as plant-derived polyphenols and carotenoids, vitamins B2, C, and E, zinc and selenium, and omega-3 polyunsaturated fatty acids, must be obtained through the diet and are considered essential nutrients. When the equilibrium between the production of reactive oxygen species and their scavenging is disrupted, radical generation overwhelms the endogenous antioxidant arsenal, leading to oxidative stress-related eye disorders and aging. Therefore, the roles of antioxidants contained in dietary supplements in preventing oxidative stress-based ocular dysfunctions are also discussed. However, the results of studies investigating the efficacy of antioxidant supplementation have been mixed or inconclusive, indicating a need for future research to highlight the potential of antioxidant molecules and to develop new preventive nutritional strategies.

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“…The study was designed to compare the concentrations of water-soluble vitamins in the blood of HD patients and a healthy control group. Some studies indicate an increased risk of developing complications of diabetes mellitus (DM) among individuals with too little intake and reduced concentration of water-soluble vitamins in the blood [ 16 , 17 ]. For this reason, the study also aimed to check whether the coexistence of DM in HD patients leads to changes in the concentrations of the above-mentioned vitamins in the blood.…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

et al. 2023

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The concentration of water-soluble vitamins (except folic acid and vitamin B12) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD patients in comparison with healthy subjects and to assess the impact of diabetes mellitus (DM) coexistence on the concentration of these vitamins. The two-center study included 142 HD patients and a control group of 31 healthy subjects. Vitamins concentration was determined using high-performance liquid chromatography (HPLC). Vitamin B1, B6, and B12 levels were significantly lower in the HD group than in the control group (p <0.001). Vitamin B1 and B2 were negatively correlated with blood urea nitrogen (BUN) levels before HD (R = −0.39, R = −0.38; p <0.05). Vitamin B3, B12, and C were positively correlated with the albumin concentration (R = 0.26, R = 0.27, R = 0.28; p <0.05). Among diabetic patients, only the concentration of vitamin B1 was lower than among non-diabetic patients. The concentration of water-soluble vitamins may be related to the adequacy of dialysis, the time of laboratory determination since the last dialysis, diet, coexistence of other diseases, use of drugs, and dietary supplements in individual patients.

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Micronutrients and Diabetic Retinopathy: Evidence From The National Health and Nutrition Examination Survey and a Meta-analysis

Cited by 9 publications

References 76 publications

The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review

The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review

Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases

Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

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