Microparticles as regulators of inflammation: Novel players of cellular crosstalk in the rheumatic diseases

Distler, Jörg H W; Pisetsky, David S.; Huber, Lars C; Kalden, Joachim R.; Distler, Oliver

doi:10.1002/art.21350

Cited by 220 publications

(200 citation statements)

References 74 publications

Supporting

Mentioning

188

Contrasting

Unclassified

Order By: Relevance

“…Similar to exosomes and apoptotic bodies, MPs can exhibit phosphatidylserine, in consequence to the loss of membrane asymmetry that occurs during their release [62][63][64][65]. All of these markers may be detected by flow cytometry and used to distinguish platelet MPs from other circulating MPs derived, for instance, from endothelial cells and red blood cells.…”

Section: Platelet Mpsmentioning

confidence: 99%

The clinical significance of platelet microparticle-associated microRNAs

Provost

2017

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

Abstract:Circulating blood platelets play a central role in the maintenance of hemostasis. They adhere to subendothelial extracellular matrix proteins that become exposed upon vessel wall damage, which is followed by platelet activation, further platelet recruitment, platelet aggregation and formation of an occlusive, or non-occlusive, platelet thrombus. Platelets host a surprisingly diverse transcriptome, which is comprised of ~ 9500 messenger RNAs (mRNAs) and different classes of non-coding RNAs, including microRNAs, as well as a significant repertoire of proteins that contribute to their primary (adhesion, aggregation, granule secretion) and alternative (RNA transfer, mRNA translation, immune regulation) functions. Platelets have the propensity to release microparticles (MPs; 0.1-1 μm in diameter) upon activation, which may mediate inflammatory responses and contribute to exacerbate inflammatory diseases and conditions. Carrying components of the platelets' cytoplasm, platelet MPs may exert their effects on recipient cells by transferring their content in platelet-derived bioactive lipid mediators, cytokines, mRNAs and microRNAs. Platelet MP-associated microRNAs may thus function also outside of platelets and play an important role in intercellular signaling and gene expression programming across the entire circulatory system. The role and importance of platelet MP-associated microRNAs in various aspects of biology and pathophysiology are increasingly recognized, and now provide the scientific basis and rationale to support further translational research and clinical studies. The clinical significance, pathophysiological role as well as the diagnostic and therapeutic potential of platelet MP-associated microRNAs in cardiovascular diseases, platelet transfusion and cancer will be discussed.

show abstract

Section: Platelet Mpsmentioning

confidence: 99%

The clinical significance of platelet microparticle-associated microRNAs

Provost

2017

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

“…It is possible that locally produced MPs may therefore contribute to the local coronary inflammatory processes in ACS (16)(17)(18)(19), although the exact mechanisms are currently poorly understood. Several clinical studies have shown correlation between circulating MP levels and clinical outcomes, markers of myocardial damage, inflammation and indices of microvascular dysfunction (20)(21)(22)(23)(24)(25).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Microparticles in acute coronary syndrome

Mavroudis

Eleftheriou²,

Hong³

et al. 2017

Thrombosis Research

View full text Add to dashboard Cite

show abstract

“…Microparticles are small, membrane-bound structures that are released from cells by exocytic budding of the membrane during activation or apoptosis (19). During the budding process, the normal membrane asymmetry is lost, and phosphatidylserine appears on the outer leaflet of the microparticle membrane (20).…”

mentioning

confidence: 99%

“…Microparticles have important functions in intercellular communication (21). Microparticles not only represent a concentrated source of immunologically active molecules but also have been shown to transport cell surface receptors and lipids between different cell types (19). Via these mechanisms, microparticles have a profound impact on cells to regulate diverse processes such as inflammation, coagulation, antigen presentation, and apoptosis (19).…”

mentioning

confidence: 99%