Microparticles: Inflammatory and haemostatic biomarkers in Polycystic Ovary Syndrome

Abstract

Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p < 0.05). TFMPs was similar between the groups (p = 0.379). In conclusion, these MPs populations could be useful biomarkers for association with thrombosis and cardiovascular disease in PCOS women.

Assessing C reactive protein/albumin ratio as a new biomarker for polycystic ovary syndrome: a case–control study of women from Bahraini medical clinics

“… 7 15 16 Chronic inflammation also contributes to endothelial dysfunction, exacerbating the development of atherosclerotic plaques, triggering the onset of CVD. 17 As such inflammation has been associated with both CVD and coronary artery disease in women with PCOS. 10 …”

Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases

“…MPs are also a type of EVs and play a fundamental role in the communication between source and target cells. Serum MPs' content can increase in variety of conditions, including PCOS (Willis et al, 2014;Carvalho et al, 2017b), prothrombotic states (Mooberry et al, 2016), and type 2 diabetes mellitus (Koga et al, 2005). Younger women with PCOS have increased concentrations of circulating annexin V-positive platelet MPs in plasma, compared with older women with PCOS (Willis et al, 2014).…”

“…The relationship between MPs and the other symptoms of PCOS have not yet been established (Teede et al, 2010). MPs may serve as useful biomarkers for predicting many diseases, including PCOS and cardiovascular disease (Carvalho et al, 2017b). The ratio of ornithine to arginine in plasma derived from PCOS patients is significantly increased (Kyselova et al, 2019).…”

“…Treat tools Prado et al, 2008 Promising biomarkers for diagnostic diseases Lugli et al, 2015;Machida et al, 2015;Muth et al, 2015;Carvalho et al, 2017b;Bertoldi et al, 2018;Kyselova et al, 2019 Drug delivery tools Yoshida et al, 2019Vaccines Raposo et al, 1996Zitvogel et al, 1998;Chaput and Thery, 2011 Basic research…”

Sympathetic innervation regulates macrophage activity in rats with polycystic ovary

“…On the other hand, it has been demonstrated that Kiss mRNA expression is increased by TNFα, IL-6, MCP-1 and VCAM-1 in human endothelial cells, and thus, accelerates atherogenesis by enhancing the inflammatory responses (Sato et al 2017). PCOS is associated with chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications (Carvalho et al 2017), accompanied by high plasma levels of kiss (Chen et al 2010). In contrast, the decreased expression of kiss mediates acute immune/ inflammatory stress-induced suppression of gonadotropin secretion in female rats (Iwasa et al 2008).…”