Micropatterned Fibrous Scaffold Produced by Using Template-Assisted Electrospinning Technique for Wound Healing Application

Norzain, Norul Ashikin; Yu, Zhiwei; Lin, Wei-Chih; Su, Hsing‐Hao

doi:10.3390/polym13162821

Cited by 10 publications

(4 citation statements)

References 48 publications

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“…This phenomenon may be due to the stretching and bonding of fibers [ 45 ]. The stretching process effectively reduces fiber thickness [ 46 ], promoting a dense arrangement among them [ 47 ] and ultimately leading to lower porosity [ 48 , 49 ]. Moreover, our method ensures a better uniform fiber distribution compared with other rotated electrospinning methods.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of a Triple-Layer Bionic Vascular Scaffold via Hybrid Electrospinning

Ma,

Huang,

Wang

2024

JFB

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Tissue engineering aims to develop bionic scaffolds as alternatives to autologous vascular grafts due to their limited availability. This study introduces a novel wet-electrospinning fabrication technique to create small-diameter, uniformly aligned tubular scaffolds. By combining this innovative method with conventional electrospinning, a bionic tri-layer scaffold that mimics the zonal structure of vascular tissues is produced. The inner and outer layers consist of PCL/Gelatin and PCL/PLGA fibers, respectively, while the middle layer is crafted using PCL through Wet Vertical Magnetic Rod Electrospinning (WVMRE). The scaffold’s morphology is analyzed using Scanning Electron Microscopy (SEM) to confirm its bionic structure. The mechanical properties, degradation profile, wettability, and biocompatibility of the scaffold are also characterized. To enhance hemocompatibility, the scaffold is crosslinked with heparin. The results demonstrate sufficient mechanical properties, good wettability of the inner layer, proper degradability of the inner and middle layers, and overall good biocompatibility. In conclusion, this study successfully develops a small-diameter tri-layer tubular scaffold that meets the required specifications.

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Section: Discussionmentioning

confidence: 99%

Fabrication of a Triple-Layer Bionic Vascular Scaffold via Hybrid Electrospinning

Ma,

Huang,

Wang

2024

JFB

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“…The fabrication of nanofibrous scaffolds for skin tissue engineering using a template-assisted electrospinning technique was employed in the production of structural scaffolds with the use of polycaprolactone. This resulted in the increment of fibroblast cell proliferation, elongation, and enhanced wound closure rate [ 89 ].…”

Section: Commonly Employed Manufacturing Techniquesmentioning

confidence: 99%

Nanofibrous Scaffolds for Diabetic Wound Healing

Aliyu

Adeleke

2023

Pharmaceutics

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Chronic wounds are one of the secondary health complications that develop in individuals who have poorly managed diabetes mellitus. This is often associated with delays in the wound healing process, resulting from long-term uncontrolled blood glucose levels. As such, an appropriate therapeutic approach would be maintaining blood glucose concentration within normal ranges, but this can be quite challenging to achieve. Consequently, diabetic ulcers usually require special medical care to prevent complications such as sepsis, amputation, and deformities, which often develop in these patients. Although several conventional wound dressings, such as hydrogels, gauze, films, and foams, are employed in the treatment of such chronic wounds, nanofibrous scaffolds have gained the attention of researchers because of their flexibility, ability to load a variety of bioactive compounds as single entities or combinations, and large surface area to volume ratio, which provides a biomimetic environment for cell proliferation relative to conventional dressings. Here, we present the current trends on the versatility of nanofibrous scaffolds as novel platforms for the incorporation of bioactive agents suitable for the enhancement of diabetic wound healing.

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“…More recently, Norzain et al [2021] fabricated nanofibrous scaffolds of different morphologies by modifying their collector template. In in vivo studies, the triangular prism patterned 3D scaffold improved wound healing compared to a 2D scaffold.…”

Section: Electrospinningmentioning

confidence: 99%

Developing Fibrous Biomaterials to Modulate Epithelial to Mesenchymal Transition

Blake¹,

Özdemir²

2023

Cells Tissues Organs

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Despite their critical roles in tissue repair and pathological processes such as fibrosis, tumor invasion and metastasis, the origins of mesenchymal cells remain poorly understood. Among the likely routes, epithelial to mesenchymal transitions (EMTs) emerge as important source of these cells. EMTs manifests themselves as a phenotypic transition in terminally differentiated epithelial cells into mesenchymal cells which is closely related to embryogenesis and organ development as well as in chronically inflamed tissues and neoplasia. There exists a potential for successful engineering of biomimetic environments that closely reflects and reciprocates the dynamic changes in the cellular microenvironment during EMT and relies on integrating the mechanical sensing mechanisms found in the native tissues into the synthetic scaffolds to understand cellular plasticity. Extracellular matrix (ECM) has complex structures composed of a collection of extracellular molecules including fibrous proteins and glycoproteins in a hydrated mixture of glycosaminoglycans and proteoglycans. Therefore, fibrous materials have been increasingly applied in tissue engineering applications since biomaterials need to restore ECM structures to provide physical, biochemical and biomechanical signals to define cellular behaviors and tissue functions. This review summarizes materials used for fibrous scaffolds including natural and synthetic materials, highlights recent development of fabrication techniques, characteristic architectures and properties and different applications of fibrous scaffolds in tissue engineering. The prospects and challenges about fibrous materials in tissue engineering applications are also discussed. Finally, we summarized relevant bioengineering approaches to modulate each type of EMT as potential avenues to consider towards future biomaterials design.

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Micropatterned Fibrous Scaffold Produced by Using Template-Assisted Electrospinning Technique for Wound Healing Application

Cited by 10 publications

References 48 publications

Fabrication of a Triple-Layer Bionic Vascular Scaffold via Hybrid Electrospinning

Fabrication of a Triple-Layer Bionic Vascular Scaffold via Hybrid Electrospinning

Nanofibrous Scaffolds for Diabetic Wound Healing

Developing Fibrous Biomaterials to Modulate Epithelial to Mesenchymal Transition

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