Microporous membranes of PLLA/PCL blends for periosteal tissue scaffold

Kouya, Tomoaki; Tada, Shin Ichiro; Minbu, Hiromi; Nakajima, Yu; Horimizu, Makoto; Kawase, Tomoyuki; Lloyd, Douglas R.; Tanaka, Takaaki

doi:10.1016/j.matlet.2012.12.076

Cited by 26 publications

(22 citation statements)

References 11 publications

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“…[21][22][23] Among these approaches, TIPS is a facile method to fabricate nanofibers in the same size range as natural ECM collagen fibers (50-500 nm). [32][33][34][35] Poly(L-lactide-co-E-caprolactone) (PLCL) copolymers have received widespread recent attentions for use in vascular tissue engineering because of their inherent elasticity and flexibility, and tailorable degradation properties. 12,24,25 In addition to the above architectural feature, scaffolds for vascular tissue engineering should be biocompatible, nonthrombogenic, nonimmunogenic, and should possess appropriate biomechanical properties, [26][27][28] which depends essentially on the nature of the polymer used.…”

Section: Introductionmentioning

confidence: 99%

Heparinized PLLA/PLCL nanofibrous scaffold for potential engineering of small‐diameter blood vessel: Tunable elasticity and anticoagulation property

Wang

et al. 2014

J Biomedical Materials Res

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The success of tissue engineered vascular grafts depends greatly on the synthetic tubular scaffold, which can mimic the architecture, mechanical, and anticoagulation properties of native blood vessels. In this study, small-diameter tubular scaffolds were fabricated with different weight ratios of poly(l-lactic acid) (PLLA) and poly(l-lactide-co-ɛ-caprolactone) (PLCL) by means of thermally induced phase separation technique. To improve the anticoagulation property of materials, heparin was covalently linked to the tubular scaffolds by N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide coupling chemistry. The as-prepared PLLA/PLCL scaffolds retained microporous nanofibrous structure as observed in the neat PLLA scaffolds, and their structural and mechanical properties can be fine-tuned by changing the ratio of two components. The scaffold containing 60% PLCL content was found to be the most promising scaffold for engineering small-diameter blood vessel in terms of elastic properties and structural integrity. The heparinized scaffolds showed higher hydrophilicity, lower protein adsorption ability, and better in vitro anticoagulation property than their untreated counterparts. Pig iliac endothelial cells seeded on the heparinized scaffold showed good cellular attachment, spreading, proliferation, and phenotypic maintenance. Furthermore, the heparinized scaffolds exhibited neovascularization after subcutaneous implantation into the New Zealand white rabbits for 1 and 2 months. Taken together, the heparinized PLLA/PLCL nanofibrous scaffolds have the great potential for vascular tissue engineering application.

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Section: Introductionmentioning

confidence: 99%

Heparinized PLLA/PLCL nanofibrous scaffold for potential engineering of small‐diameter blood vessel: Tunable elasticity and anticoagulation property

Wang

et al. 2014

J Biomedical Materials Res

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“…The data from the mechanical tensile tests allow us to conclude that the addition of PCL-T has great influence on the membrane's mechanical properties, especially the modulus of elasticity and strain, considering the elongation at break of solid PLLA is typically 3% (7). In this study, the 10% plasticizer preparation was the ideal membrane: it presented satisfactory results in the tensile tests and excellent thermal properties in comparison with solid polymers, in addition to malleability, which is very important in surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

Development, Characterization, and Cellular Adhesion of Poly(l‐Lactic Acid)/Poly(Caprolactone Triol) Membranes for Potential Application in Bone Tissue Regeneration

et al. 2013

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Poly(l-lactide)/poly(caprolactone triol) (PLLA/ PCL-T) membranes were prepared by solution casting in 100/0, 90/10, and 70/30 (w/w) ratios. The membranes were analyzed by dynamic mechanical analysis, differential scanning calorimetry, and mechanical tests.The thermal analysis showed that the 90/10 and 70/30 preparations were partly miscible systems. The glass transition temperature (Tg) of PLLA decreases as the PCL-T concentration increases, which implies that PCL-T has a plasticizer function. An in vitro study with osteoblastic cells isolated from the calvariae of rats was performed in all preparations. The results obtained in this study showed that the addition of PCL-T to the PLLA matrix modifies its mechanical, thermal, and biological properties. These blends could be useful for tissue engineering for bone applications.

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“…As it was previously mentioned, suitable techniques in modification of mechanical features are synthesis of copolymers with other monomers or preparation of blends with polylactones, polyethers, poly(amino acids), polycarbonates, polyurethanes and other polymers of natural and synthetic origin [34][35][36][37].…”

Section: Application Of Biodegradable Polymers In Tissue Engineeringmentioning

confidence: 99%

Biodegradable polymers suitable for tissue engineering and drug delivery systems

Porjazoska-Kujundziski¹,

Chamovska²

2017

Zas Mat

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Microporous membranes of PLLA/PCL blends for periosteal tissue scaffold

Cited by 26 publications

References 11 publications

Heparinized PLLA/PLCL nanofibrous scaffold for potential engineering of small‐diameter blood vessel: Tunable elasticity and anticoagulation property

Heparinized PLLA/PLCL nanofibrous scaffold for potential engineering of small‐diameter blood vessel: Tunable elasticity and anticoagulation property

Development, Characterization, and Cellular Adhesion of Poly(l‐Lactic Acid)/Poly(Caprolactone Triol) Membranes for Potential Application in Bone Tissue Regeneration

Biodegradable polymers suitable for tissue engineering and drug delivery systems

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