MicroRNA-126-3p Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Regulating VCAM-1 Expression

Fu, Xi; Niu, Tiesheng; Li, Xiaodong

doi:10.3389/fnins.2019.00866

Cited by 44 publications

(31 citation statements)

References 46 publications

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“…miR-126 also regulates BBB or BRB function. miR-126-3p mimic or miR-126 expressing plasmid attenuated hemorrhage-induced BBB or ischemia-induced BRB disruption respectively, which is associated with upregulation of its target VCAM-1 40,41 . In a rat model of contusion spinal cord injury model, miR-126 promoted angiogenesis and inhibited leukocyte extravasation and inflammation via targeting Spred-1, PI3KR2 and VCAM-1 42 .…”

Section: Dis-regulation and Beneficial Role Of Mir-126 In Vascular DImentioning

confidence: 97%

An integrated hypothesis for miR-126 in vascular disease

Jiang

Wang

et al. 2020

MRAJ

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microRNA miR-126 was among the early discovered miRNAs that are expressed specifically in the vasculature and have critical functions in vascular development. Recent studies have started to unveil potentially important function of miR-126 in vascular diseases, including atherosclerosis, coronary artery disease, stroke and diabetic vasculopathy. The action of miR-126 reflects its function in angiogenesis and inflammation. The expression of miR-126 is downregulated in a variety of vascular diseases, and miR-126 overexpression appears to beneficial for most vascular disease models. In the minireview, we summarize the historic and current research regarding miR-126 function and mechanisms in the vascular system, its link to long noncoding RNAs (lncRNA), as well as the potential of miR-126-based therapeutics for vascular diseases. To explain the seemingly conflicting function of miR-126 from different studies, an integrated hypothesis is proposed that miR-126 has strand-and cell type-specific functions in angiogenesis and inflammation, making it beneficial in many different vascular disease models.

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Section: Dis-regulation and Beneficial Role Of Mir-126 In Vascular DImentioning

confidence: 97%

An integrated hypothesis for miR-126 in vascular disease

Jiang

Wang

et al. 2020

MRAJ

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“…miR‐126, which is upregulated in chronic inactive lesions, might participate in this restoration. A recent study found that miR‐126‐3p reduced blood–brain barrier leakage following intracerebral hemorrhage via regulation of VCAM‐1 .…”

Section: There Is Significant and Reproducible Overlap Of Mirna Profimentioning

confidence: 99%

MicroRNAs in gray and white matter multiple sclerosis lesions: impact on pathophysiology

Teuber‐Hanselmann

Meinl

Junker

2020

The Journal of Pathology

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Multiple sclerosis (MS) is a chronic disease of the CNS, hallmarked by inflammation and demyelination. Early stages of the disease frequently show active lesions containing numerous foamy macrophages and inflammatory cells. Disease progression is highlighted by increasing numbers of mixed active/inactive or inactive lesions showing sparse inflammation and pronounced astrogliosis. Furthermore, gray matter lesions increase in number and extent during disease progression. MicroRNAs (miRNAs) comprise a group of several thousand (in humans more than 2000), small non-coding RNA molecules with a fundamental influence on about one-third of all protein-coding genes. Furthermore, miRNAs have been detected in body fluids, including spinal fluid, and they are assumed to participate in intercellular communications. Several studies have determined miRNA profiles from dissected white and gray matter lesions of autoptic MS patients. In this review, we summarize in detail the current knowledge of individual miRNAs in gray and white matter lesions of MS patients and present the concepts of MS tissue lesion development based on the altered miRNA profiles.No conflicts of interest were declared.

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“…Considering this evidence, the accurate role and underlying mechanism of miR-340-5p in ICH attract our interest. Currently, the collagenase-induced model is widely used as a prevalent animal model to better mimic human ICH syndrome [21,22]. In the present study, the collagenase-induced ICH rat model was established to investigate the role of miR-340-5p in ICH-induced brain injury in vitro.…”

Section: Pdcd4 Was a Direct Target Gene Of Mir-340-5pmentioning

confidence: 99%

Protective Effect of miR-340-5p against Brain Injury after Intracerebral Hemorrhage by Targeting PDCD4

Zhou

Huang

et al. 2020

Cerebrovasc Dis

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Objective: Intracerebral hemorrhage (ICH) is a common cerebrovascular disease. Increasing evidence has documented the crucial role of microRNAs in ICH. The present study aimed to investigate the role and underlying mechanism of miR-340-5p in ICH. Methods: The collagenase-induced ICH rat model was established. The neurological function of rats and the cerebral water content of rat brain tissue were measured to assess the brain injury. BV-2 cells were recruited and treated by LPS to mimic ICH-induced inflammatory response. qRT-PCR was used for the measurement of miR-340-5p. The protein levels of TNF-α, IL-6, and IL-1β were detected using ELISA. Luciferase reporter gene assay was performed to confirm the target gene. Results: Downregulation of miR-340-5p was detected in the serum of ICH patients and the brain tissues of ICH rats. Overexpression of miR-340-5p reversed the influence of ICH on the neurological function score and cerebral water content and inhibited the production of proinflammatory cytokines (TNF-α, IL-6, and IL-1β), which were induced by ICH in vivo. In in vitro study, levels of TNF-α, IL-6, and IL-1β were significantly enhanced in cells after LPS treatment, but these increases were eliminated by overexpression of miR-340-5p. PDCD4 was a direct target gene of miR-340-5p. Conclusion: miR-340-5p protects against brain injury after ICH. miR-340-5p might exert an anti-inflammatory effect during the occurrence of ICH via targeting PDCD4.

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MicroRNA-126-3p Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Regulating VCAM-1 Expression

Cited by 44 publications

References 46 publications

An integrated hypothesis for miR-126 in vascular disease

An integrated hypothesis for miR-126 in vascular disease

MicroRNAs in gray and white matter multiple sclerosis lesions: impact on pathophysiology

Protective Effect of miR-340-5p against Brain Injury after Intracerebral Hemorrhage by Targeting PDCD4

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