MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines

Crawford, Melissa; Brawner, Emily J.; Batte, Kara; Liu, Yü; Hunter, Melissa; Otterson, Gregory A.; Nuovo, Gerard J.; Marsh, Clay B.; Nana‐Sinkam, S. Patrick

doi:10.1016/j.bbrc.2008.06.090

Cited by 249 publications

(205 citation statements)

References 31 publications

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“…miR‐126 is mainly expressed within the vascular ECs, which is highly associated with angiogenesis during normal development and injury healing 46, 47, 48. MiR‐126‐3p and miR‐126‐5p are the two mature strands of the pre‐miR‐126 with cell‐type and strand‐specific function in angiogenesis 49, 50.…”

Section: Mirnas That Target Genes Involved In Angiogenesismentioning

confidence: 99%

The regulatory role of microRNAs in angiogenesis‐related diseases

Sun

Lei

et al. 2018

J Cellular Molecular Medi

119

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MicroRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression at a post‐transcriptional level via either the degradation or translational repression of a target mRNA. They play an irreplaceable role in angiogenesis by regulating the proliferation, differentiation, apoptosis, migration and tube formation of angiogenesis‐related cells, which are indispensable for multitudinous physiological and pathological processes, especially for the occurrence and development of vascular diseases. Imbalance between the regulation of miRNAs and angiogenesis may cause many diseases such as cancer, cardiovascular disease, aneurysm, Kawasaki disease, aortic dissection, phlebothrombosis and diabetic microvascular complication. Therefore, it is important to explore the essential role of miRNAs in angiogenesis, which might help to uncover new and effective therapeutic strategies for vascular diseases. This review focuses on the interactions between miRNAs and angiogenesis, and miRNA‐based biomarkers in the diagnosis, treatment and prognosis of angiogenesis‐related diseases, providing an update on the understanding of the clinical value of miRNAs in targeting angiogenesis.

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Section: Mirnas That Target Genes Involved In Angiogenesismentioning

confidence: 99%

The regulatory role of microRNAs in angiogenesis‐related diseases

Sun

Lei

et al. 2018

J Cellular Molecular Medi

119

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“…In glioblastoma cells, CRK over-expression increases cell migration and invasion, likely through an association with DOCK180 26 and its silencing suppresses early attachment to laminin, cell motility and growth 27 . Recent studies show that CRK is down-regulated by miR-126 microRNA in lung cancer cells resulting in impaired cell adhesion, migration and invasion 93 …”

Section: Migration and Invasionmentioning

confidence: 99%

Integrin signalling adaptors: not only figurants in the cancer story

et al. 2010

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Current evidence highlights the ability of adaptor (or scaffold) proteins to create signalling platforms that drive cellular transformation upon integrin-dependent adhesion and growth factor receptor activation. The understanding of the biological effects regulated by these adaptors in tumours might be crucial for the identification of novel targets and the development of innovative therapeutic strategies for human cancer. In this review we will discuss the relevance of adaptor proteins in signalling originating from integrin-mediated cell-extracellular matrix (ECM) adhesion and growth factor stimulation within the context of cell transformation and tumour progression.Herein, we will specifically underline the contribution of p130CAS, NEDD9, CRK, and the IPP complex (ILK, PINCH and PARVIN) to cancer, along with the more recently identified p140CAP.

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“…Based on these studies, we selected miR-126 for further investigation, given that its expression is known to be highest in vascularized tissues such as the lung, heart, and kidney (5-7), and as it has been shown to be present in bronchial epithelium (8). miR-126 is 21 nucleotides in length, located on chromosome 9q34.3 and is contained within intron 5 of its host gene epidermal growth factor like-7 (6,9).…”

mentioning

confidence: 99%

“…miR-126 is 21 nucleotides in length, located on chromosome 9q34.3 and is contained within intron 5 of its host gene epidermal growth factor like-7 (6,9). In recent studies, miR-126 has been shown to have functional roles in angiogenesis (10,11), to be *Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital; and † Cancer Genetics Group, Royal College of Surgeons in Ireland, Dublin, Ireland downregulated in a number of malignancies (8,12) and to act as a tumor suppressor in breast cancer (13). In silico analysis of a number of miRNA target prediction databases shows that TOM1 is a potential target of miR-126.…”

mentioning

confidence: 99%