MicroRNA-1285-5p influences the proliferation and metastasis of non-small-cell lung carcinoma cells via downregulating CDH1 and Smad4

Zhou, Shunhua; Zhang, Zhongmian; Zheng, Peng‐Yuan; Zhao, Wenchao; Han, Ning

doi:10.1177/1010428317705513

Cited by 24 publications

(18 citation statements)

References 34 publications

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“…Moreover, hsa_circ_0001206 might function as an miR-1285-5p sponge when exerting its effect on the pathogenesis of PCa. One previous study reported that miR-1285-5p could suppress the proliferation and metastasis of lung cancer cells [35]. Moreover, miR-1285-5p was also reportedly associated with overall survival in breast cancer [36] and infiltrative growth of follicular variants of papillary thyroid carcinomas [37].…”

Section: Discussionmentioning

confidence: 95%

Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer

Song

Zhuo

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Our study is to explore the expression profiles and potential functions of circRNAs in prostate cancer (PCa). A total of 95 circRNAs and 830 mRNAs were screened to be significantly differentially expressed in PCa tissues by microarrays. Co-expression and competitive endogenous RNA (ceRNA) network were constructed to reveal the potential regulatory mechanisms of circRNAs. Three circRNAs, hsa_circ_0001206, hsa_circ_0001633, and hsa_circ_0009061 were validated to be down-regulated in PCa by quantitative real-time PCR (qRT-PCR) and hsa_circ_0001206 as well as hsa_circ_0009061 was significantly associated with clinical features of PCa patients. Meanwhile, Receiver Operating Characteristic (ROC) curves showed their good diagnostic value as biomarkers for PCa. The down-regulation of hsa_circ_001206 was partly because of the regulation of DExH-Box Helicase 9 (DHX9). Moreover, overexpression of hsa_circ_0001206 inhibited PCa cell proliferation, migration, and invasion in vitro and prevented tumor growth in vivo. Dual-luciferase reporter assays showed hsa_circ_0001206 could directly bind to miR-1285-5p. The expression of Smad4, a well-known suppressive gene in PCa, can be increased by overexpression of hsa_circ_0001206 and this effect could be partly reversed by co-transfection of miR-1285-5p mimic. The study revealed expression profiles and potential functions of circRNAs and demonstrated hsa_circ_0001206 played a suppressive role in the pathogenesis of PCa. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 95%

Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer

Song

Zhuo

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Zhang et al [21] reported that application of 2 phytotherapeutic agents restored miRNA-331-5p expression and exerted neuroprotective effects by preventing ischaemia-induced inflammasome activation, whereas miRNA-331-5p inhibition counteracted these effects. Concerning miR-1285-5p, neonatal and neuroscientific research is scarce, but the literature suggests a role of miRNA-1285-5p in regulation of cell proliferation [22, 23].…”

Section: Discussion/conclusionmentioning

confidence: 99%

MicroRNA Expression Profiles as Diagnostic and Prognostic Biomarkers of Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy

et al. 2022

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Introduction: Perinatal asphyxia is a leading cause of neonatal death. Up to one-third of asphyxiated neonates suffer from hypoxic-ischaemic encephalopathy (HIE) with substantial long-term morbidity. Currently available diagnostic and prognostic tools bear limitations, and additional reliable biomarkers are needed for all stages of clinical management. A novel tool in neuroscientific research is micro-ribonucleic acid (miRNA) profiling. The aim of the present study was to determine miRNA expression profiles of healthy and asphyxiated neonates with and without HIE and to assess their potential as diagnostic and prognostic biomarkers. Methods: We prospectively enrolled 49 neonates with a gestational age of ≥36 weeks, 15 of which fulfilled the diagnostic criteria of perinatal asphyxia and 34 served as healthy controls. Dried blood spots were collected from umbilical cord blood (UCB) and from venous blood upon admission to neonatal intensive care unit (NICU) and at 48 h of life. Samples were analysed by means of FirePlex™ technology (Abcam, Cambridge, MA, USA). Results: In the UCB, miRNA expression levels of hsa-mir-124-3p, hsa-mir-1285-5p, and hsa-mir-331-5p were significantly lower in asphyxiated neonates compared to healthy controls. Asphyxiated neonates requiring therapeutic hypothermia had significantly increased expression of hsa-miR-30e-5p and significantly decreased expression of hsa-miR-142-3p, hsa-miR-338-3p, hsa-miR-34b-3p, hsa-miR-497-5p, and hsa-miR-98-5p at the time of admission to the NICU. At 48 h, infants suffering from moderate/severe HIE with a poor long-term neurodevelopmental outcome showed a significant increase in hsa-mir-145-5p. Discussion/Conclusion: MiRNA profiling shows promise as a biomarker for perinatal asphyxia, hypothermia-requiring HIE, and poor neurodevelopmental outcome. Confirmatory studies are called for.

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“…To explore its potential interaction with miRNAs, miR-1285-5p was predicted by homemade microRNA target prediction software from Array star and sooner it was confirmed by dualluciferase. MiR-1285-5p was systematically defined as regulatory factor in tumor progression [83]. Previous reports had indicated that miR-1285-5p could influence the overall survival in breast cancer and infiltrative growth of follicular varients of papillary thyroid carcinomas [84,85].…”

Section: The Epigenetical Roles Of Circular Rnas In Prostate Cancermentioning

confidence: 99%

Advancement and properties of circular RNAs in prostate cancer: An emerging and compelling frontier for discovering

et al. 2021

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Prostate cancer (PC) is the most common carcinoma among men worldwide which results in 26% of leading causes of cancer-related death. However, the ideal and effective molecular marker remains elusive. CircRNA, initially observed in plant-infected viruses and Sendai virus in 1979, is generated from pre-mRNA back-splicing and comes in to play by adequate expression. The differential expression in prostate tissues compared with the control reveals the promising capacity in modulating processes including carcinogenesis and metastasis. However, the biological mechanisms of regulatory network in PC needs to systemically concluded. In this review, we enlightened the comprehensive studies on the definite mechanisms of circRNAs affecting tumor progression and metastasis. What's more, we validated the potential clinical application of circRNAs serving as diagnostic and prognostic biomarker. The discussion and analysis in circRNAs will broaden our knowledge of the pathogenesis of PC and further optimize the current therapies against different condition.

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MicroRNA-1285-5p influences the proliferation and metastasis of non-small-cell lung carcinoma cells via downregulating CDH1 and Smad4

Cited by 24 publications

References 34 publications

Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer

Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer

MicroRNA Expression Profiles as Diagnostic and Prognostic Biomarkers of Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy

Advancement and properties of circular RNAs in prostate cancer: An emerging and compelling frontier for discovering

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