MicroRNA-133a and Myocardial Infarction

Xiao, Yi; Zhao, Ji-Ling; Tuazon, Julian P.; Borlongan, Cesar V.; Yu, Guopan

doi:10.1177/0963689719843806

Cited by 109 publications

(75 citation statements)

References 68 publications

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“…The infarcted heart shows typical cell death cascades demonstrated by a loss of cells and fibrotic scarring in the myocardium. Cardiac hypertrophy and fibrosis mainly lead to ventricular wall thickening and stiffening, which defining an adverse cardiac remodeling which eventually causes impaired cardiac function and consequently hearts failure [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Optimal Time Repair of Ventricular Septal Rupture Post Myocardial Infarction

Shafiei¹,

Jannati²,

Jannati³

2020

Journal of the Saudi Heart Association

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Ventricular septal rupture (VSR) is an uncommon complication of myocardial infarction (MI). The mortality rate of VSR is high. The management of VSR is including the stabilization of the hemodynamic status and surgical closure of the rupture. In spite of the agreement of experts on the necessity of surgical repair, the timing of VSR repair management remains unclear. In this review article, we evaluate the optimal time repair of VSR. To collect the data, Pubmed, EMBASE, and Cochrane Central Registry databases were searched for potentially suitable studies. Search terms were including “Ventricular Septal Rupture”, “Myocardial Infarction”, “Timing”, and “MI”. According to the result of the studies, it seems that the time between VSR detection and its repair is a determining factor in the survival or mortality of patients in post-myocardial infraction VSR. Studies showed that earlier surgical repair in VSR increases the risk of mortality, because in the early phase after MI, infarcted myocardium is very fragile, and it is very difficult surgical repair and increases the risk of recurrent septal defects. The longer time is needed for the heart and different body systems to adapt to the hemodynamic results of the abrupt left to right shunt. It seems that the best time for the operation is after the maturation of VSR with scarring at the edges of the defect. Moreover, in a large number of patients, it is not possible to delay the operation since they are at risk of severe heart failure and organ dysfunction. In these cases operation immediately after diagnosis of VSR is recommended to prevent further hemodynamic deterioration. In hemodynamically compromised patients, it may be considered to use a ventricular assist device, requiring an intra-aortic balloon pump (IABP), or extracorporeal membrane oxygenation (ECMO) preoperative to postpone the operation which leads to higher survival in post-MI-VSD.

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Section: Introductionmentioning

confidence: 99%

Optimal Time Repair of Ventricular Septal Rupture Post Myocardial Infarction

Shafiei¹,

Jannati²,

Jannati³

2020

Journal of the Saudi Heart Association

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“…The present study focused on examination of miR-1, miR-133a/b, miR-135a, and miR-29b due to their involvement in cardiac remodeling processes including inflammation, apoptosis, arrhythmias, and fibrosis. Furthermore, miR-1 and miR-133 are cardiac-specific markers [ 10 ] and two of the most abundant miRs in the heart [ 11 ]. Increased expression of miR-1 has been associated with arrhythmias after an MI [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

et al. 2020

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MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). Dietary flaxseed has demonstrated a protective effect against an MI. The present study was carried out to test the hypothesis that dietary flaxseed supplementation before and after an MI regulates the expression of above-mentioned miRNAs to produce its cardioprotective effect. Animals were randomized after inducing MI by coronary artery ligation into: (a) sham MI with normal chow, (b) MI with normal chow, and (c–e) MI supplemented with either 10% milled flaxseed, or 4.4% flax oil enriched in alpha-linolenic acid (ALA), or 0.44% flax lignan secoisolariciresinol diglucoside. The feeding protocol consisted of 2 weeks before and 8 weeks after the surgery. Dietary flax oil supplementation selectively upregulated the cardiac expression of miR-133a, miR-135a, and miR-29b. The levels of collagen I expression were reduced in the flax oil group. We conclude that miR-133a, miR-135a, and miR-29b are sensitive to dietary flax oil, likely due to its rich ALA content. The cardioprotective effect of flaxseed in an MI could be due to modulation of these miRNAs.

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“…Among these types of noncoding RNAs, various miR-NAs are widely investigated (see Figure 4). Although there is a large body of evidence regarding up-and downregulation of genes for potassium channels, SERCA, subunits of receptors, signal molecules, proinflammatory cytokines, apoptotic mediators (Bax, caspase-9) in myocardium [213][214][215][216], and miRNAs are considered rather targets for personifying intervention and translational therapy, as well as prognosticators than diagnostic biomarkers for adverse cardiac remodelling and HF [217]. However, having signatures of miRNAs, which correspond to adverse cardiac remodelling, HF, sudden death, and cardiac abnormalities with established poor prognosis, such as concentric LV hypertrophy, fibrosis, and inflammation, it has not completely understood whether the "miRNA card" personally created for each patient will have clinical significance in the prediction of HF [33,218].…”

Section: Other Biomarkers Of Cardiac Remodellingmentioning

confidence: 99%

Adverse Cardiac Remodelling after Acute Myocardial Infarction: Old and New Biomarkers

Berezin

2020

Disease Markers

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The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous studies have examined the diagnostic and prognostic potencies of circulating cardiac biomarkers in acute coronary syndrome/AMI and heart failure after AMI, and even fewer have depicted the utility of biomarkers in AMI patients undergoing primary PCI. Although complete revascularization at early period of acute coronary syndrome/AMI is an established factor for improved short-term and long-term prognosis and lowered risk of cardiovascular (CV) complications, late adverse cardiac remodelling may be a major risk factor for one-year mortality and postponded heart failure manifestation after PCI with subsequent blood flow resolving in culprit coronary artery. The aim of the review was to focus an attention on circulating biomarker as a promising tool to stratify AMI patients at high risk of poor cardiac recovery and developing HF after successful PCI. The main consideration affects biomarkers of inflammation, biomechanical myocardial stress, cardiac injury and necrosis, fibrosis, endothelial dysfunction, and vascular reparation. Clinical utilities and predictive modalities of natriuretic peptides, cardiac troponins, galectin 3, soluble suppressor tumorogenicity-2, high-sensitive C-reactive protein, growth differential factor-15, midregional proadrenomedullin, noncoding RNAs, and other biomarkers for adverse cardiac remodelling are discussed in the review.

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MicroRNA-133a and Myocardial Infarction

Cited by 109 publications

References 68 publications

Optimal Time Repair of Ventricular Septal Rupture Post Myocardial Infarction

Optimal Time Repair of Ventricular Septal Rupture Post Myocardial Infarction

Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

Adverse Cardiac Remodelling after Acute Myocardial Infarction: Old and New Biomarkers

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